Photothermal effect enhancing graphene quantum dots/semiconducting polymer/nanozyme-mediated cancer catalytic therapy

Hu, Linyu; Sun, Weiyi; Yuying, Tang; Su, Li; Zhang, Bei; Sun, Xuetong; Ji, Wenwen; Ma, Lijuan; Deng, Haishan; Han, Seung Hoon; Zhu, Dong

doi:10.1016/j.carbon.2021.01.132

Cited by 33 publications

(17 citation statements)

References 23 publications

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“…Due to quantum confinement and edge effects, the internal electron motion of GQDs is limited in all directions. In addition to their small size, GQDs have a large specific surface area and abundant edge sites, which endows them with excellent electrical and optical properties (Ponomarenko et al, 2008;Li et al, 2012;Yan et al, 2013;Hu et al, 2021). In a previous study, we had fabricated a high-performance MEG device by using small-sized (2-5 nm) GQDs that were prepared by direct oxidation and etching of natural graphite powder.…”

Section: )mentioning

confidence: 99%

Graphene-Based Assemblies for Moist-Electric Generation

2021

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Moisture is a ubiquitous and clean resource in nature, which continuously diffuses in the atmosphere and demonstrates huge chemical potential energy that is difficult to be utilized. Recently, the generation of power from interactions between graphene and gaseous water molecules in moisture has triggered great research interest that could provide a novel energy conversion system for our society. graphene-based assemblies have been considered as ideal platforms for moist-electric generation (MEG) in many studies, because of the abundant of functional groups, controllable microstructure and diverse macro morphologies. Therefore, in this short review, we will first state the preparation techniques of graphene-based assemblies for MEG. Then, the fundamental mechanisms of MEG are discussed and the latest advances on graphene MEG are reviewed. Finally, an overview of the current challenges and future development trends in graphene MEG is provided.

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Section: )mentioning

confidence: 99%

Graphene-Based Assemblies for Moist-Electric Generation

2021

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“…Compared with natural enzymes, nanozymes usually have an enhanced accumulative effect within the tumors and exhibit elevated therapeutic efficiency. − These superior features make the nanozymes overcome the limitations of natural enzymes with great application potential. , Furthermore, most nanozymes could be utilized as imaging agents, providing versatile platforms for cancer diagnosis and treatment. − Thus, the combination of catalytic properties and other physicochemical functions make nanozymes an ideal medical candidate to realize efficient enzymatic therapy . Up to now, various nanomaterials have been proven with enzyme catalytic activity to accelerate biochemical reactions, such as metal–organic frameworks, metal and metal oxide nanoparticles (NPs), single-atom nanozyme, carbon-based nanomaterials, etc. − However, most of the nanozymes have low and single catalytic activity in the highly complex TME, making it difficult to achieve a satisfactory therapeutic effect. Hence, it is extremely valuable but challenging to develop nanozymes with both the distinctive properties of nanomaterials and multiple enzyme-mimicking capabilities, such as peroxidase (POD) and catalase (CAT) activities.…”

Section: Introductionmentioning

confidence: 99%

Dual Nanozyme-Driven PtSn Bimetallic Nanoclusters for Metal-Enhanced Tumor Photothermal and Catalytic Therapy

et al. 2023

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Specific generation of reactive oxygen species (ROS) within tumors in situ catalyzed by nanozymes is a promising strategy for cancer therapeutics. However, it remains a significant challenge to fabricate highly efficient nanozymes acting in the tumor microenvironment. Herein, we develop a bimetallic nanozyme (Pt50Sn50) with the photothermal enhancement of dual enzymatic activities for tumor catalytic therapy. The structures and activities of PtSn bimetallic nanoclusters (BNCs) with different Sn content are explored and evaluated systematically. Experimental comparisons show that the Pt50Sn50 BNCs exhibit the highest activities among all those investigated, including enzymatic activity and photothermal property, due to the generation of SnO2–x with oxygen vacancy (Ovac) sites on the surface of Pt50Sn50 BNCs. Specifically, the Pt50Sn50 BNCs exhibit photothermal-enhanced peroxidase-like and catalase-like activities, as well as a significantly enhanced anticancer efficacy in both multicellular tumor spheroids and in vivo experiments. Due to the high X-ray attenuation coefficient and excellent light absorption property, the Pt50Sn50 BNCs also show dual-mode imaging capacity of computed tomography and photoacoustic imaging, which could achieve in vivo real-time monitoring of the therapeutic process. Therefore, this work will advance the development of noble-metal nanozymes with optimal composition for efficient tumor catalytic therapy.

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“…Nevertheless, as biological macromolecules, the practical applications are gravely hindered by their intrinsic drawbacks, such as multifarious preparation/purification processes, high extraction cost, strict storage conditions, and particularly the low stability in severe environments . As promising alternatives to natural enzymes, nanozymes, defined as nanomaterials with inherent enzyme-mimetic properties, have aroused significant interest due to their large-scale preparation potential, low cost, convenient storage, and strong stability under harsh environments. , So far, numerous nanomaterials, such as carbon-based nanomaterials (e.g., graphene, quantum dots, and carbon dots), − noble-metal-based nanomaterials (e.g., Pd, Pt, Au, and Ag), − and metal oxide-based nanomaterials (e.g., cobalt oxide, ferric oxide, manganese oxide, and ceria (CeO 2 )), ,− have been demonstrated to possess specific enzyme-mimetic catalytic activities.…”

Section: Introductionmentioning

confidence: 99%

Au/CeO₂ NR Restricted Inside Cu-MOFs: A Three-in-One Artificial Enzyme with Synergistically Enhanced Peroxidase-Like Activity for Dual-Mode Sensing of Multiple Biomarkers

Chen

Peng

Lin

et al. 2023

ACS Sustainable Chem. Eng.

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Nanomaterials with inherent enzyme-mimetic properties have been extensively studied in biosensing field, but it is still challenging to overcome their natively weak enzyme-mimetic activity and further promote their stabilities. In this work, a three-in-one artificial enzyme with synergistically enhanced peroxidase-like activity and outstanding stability is constructed by restricting Au-loaded CeO2 nanorods (NR) (1% Au:CeO2 mass ratio) inside Cu-based metal–organic frameworks (Cu(PABA)), termed Au1/CeO2 NR@Cu(PABA). It has been demonstrated that the artificial enzyme possesses significantly improved performance in catalytic decomposition of H2O2, with ∼2.41 and ∼1.49 times higher activity than its individual constituents (Au1/CeO2 NR and Cu(PABA)), benefiting from the synergistic effect and the unique restricted structure; owns strong affinities to substrates, with separately ∼8.21- and ∼3.13-fold lower Michaelis constants toward H2O2 and o-phenylenediamine, respectively, than horseradish peroxidase; and exhibits desirable pH (4–12), thermal (30–80 °C), organic solvent (N,N-dimethylformamide, acetone, methanol, etc.), and long-term storage (30 days) stabilities, advantaging practical applications. Taking aforementioned superior properties of Au1/CeO2 NR@Cu(PABA), a universal colorimetric/fluorometric dual-mode sensing platform is built and utilized for detection of biomarkers (e.g., glucose, galactose, and cholesterol) in biological fluids with satisfactory recoveries (90.2–108%). This work offers new horizons in designing high-efficiency, stable, and credible biomimetic catalysts to accelerate future advanced engineering of nanozymes.

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Photothermal effect enhancing graphene quantum dots/semiconducting polymer/nanozyme-mediated cancer catalytic therapy

Cited by 33 publications

References 23 publications

Graphene-Based Assemblies for Moist-Electric Generation

Graphene-Based Assemblies for Moist-Electric Generation

Dual Nanozyme-Driven PtSn Bimetallic Nanoclusters for Metal-Enhanced Tumor Photothermal and Catalytic Therapy

Au/CeO₂ NR Restricted Inside Cu-MOFs: A Three-in-One Artificial Enzyme with Synergistically Enhanced Peroxidase-Like Activity for Dual-Mode Sensing of Multiple Biomarkers

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Photothermal effect enhancing graphene quantum dots/semiconducting polymer/nanozyme-mediated cancer catalytic therapy

Cited by 33 publications

References 23 publications

Graphene-Based Assemblies for Moist-Electric Generation

Graphene-Based Assemblies for Moist-Electric Generation

Dual Nanozyme-Driven PtSn Bimetallic Nanoclusters for Metal-Enhanced Tumor Photothermal and Catalytic Therapy

Au/CeO2 NR Restricted Inside Cu-MOFs: A Three-in-One Artificial Enzyme with Synergistically Enhanced Peroxidase-Like Activity for Dual-Mode Sensing of Multiple Biomarkers

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Resources

About

Au/CeO₂ NR Restricted Inside Cu-MOFs: A Three-in-One Artificial Enzyme with Synergistically Enhanced Peroxidase-Like Activity for Dual-Mode Sensing of Multiple Biomarkers