Photothermal Effectiveness of Magnetite Nanoparticles: Dependence upon Particle Size Probed by Experiment and Simulation

Johnson, Robert O.; Schultz, Jonathan D.; Lear, Benjamin J.

doi:10.3390/molecules23051234

Cited by 27 publications

(25 citation statements)

References 39 publications

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“…IONs have demonstrated to be effective PA in various applications. For instance, they can drive high barrier reactions, such as the clean decomposition of propylene carbonate [ 111 ]. Concerning biomedical applications, the intrinsic ability to generate heat within a short time under NIR laser irradiation makes IONs a novel promising hyperthermia agent.…”

Section: Iron Oxide Nanoparticles For Photothermal Therapymentioning

confidence: 99%

Iron Oxide Nanoparticles in Photothermal Therapy

2018

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Photothermal therapy is a kind of therapy based on increasing the temperature of tumoral cells above 42 °C. To this aim, cells must be illuminated with a laser, and the energy of the radiation is transformed in heat. Usually, the employed radiation belongs to the near-infrared radiation range. At this range, the absorption and scattering of the radiation by the body is minimal. Thus, tissues are almost transparent. To improve the efficacy and selectivity of the energy-to-heat transduction, a light-absorbing material, the photothermal agent, must be introduced into the tumor. At present, a vast array of compounds are available as photothermal agents. Among the substances used as photothermal agents, gold-based compounds are one of the most employed. However, the undefined toxicity of this metal hinders their clinical investigations in the long run. Magnetic nanoparticles are a good alternative for use as a photothermal agent in the treatment of tumors. Such nanoparticles, especially those formed by iron oxides, can be used in combination with other substances or used themselves as photothermal agents. The combination of magnetic nanoparticles with other photothermal agents adds more capabilities to the therapeutic system: the nanoparticles can be directed magnetically to the site of interest (the tumor) and their distribution in tumors and other organs can be imaged. When used alone, magnetic nanoparticles present, in theory, an important limitation: their molar absorption coefficient in the near infrared region is low. The controlled clustering of the nanoparticles can solve this drawback. In such conditions, the absorption of the indicated radiation is higher and the conversion of energy in heat is more efficient than in individual nanoparticles. On the other hand, it can be designed as a therapeutic system, in which the heat generated by magnetic nanoparticles after irradiation with infrared light can release a drug attached to the nanoparticles in a controlled manner. This form of targeted drug delivery seems to be a promising tool of chemo-phototherapy. Finally, the heating efficiency of iron oxide nanoparticles can be increased if the infrared radiation is combined with an alternating magnetic field.

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Section: Iron Oxide Nanoparticles For Photothermal Therapymentioning

confidence: 99%

Iron Oxide Nanoparticles in Photothermal Therapy

2018

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“…When Au is coupled with MMSN, the photothermal effect increased to a certain extent, which may be attributed to Au's surface electron oscillation after absorbing near-infrared light. As Fe 3 O 4 microspheres had stronger absorption in the near-infrared region than Au, and MNP had better photothermal conversion under nearinfrared light, 32,33 MNP temperature heating rate was higher than MMSN-Au under PT. However, things were different for magnetothermal properties because Au nanoparticles could not generate heat in an alternating electric field.…”

Section: Magnetothermal and Photothermal Propertiesmentioning

confidence: 99%

Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy

Zhang

Zhou

et al. 2021

IJN

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Introduction:Aim to obtain a NO donor that can control released NO in vivo with the high efficacy of tumor suppression and targeting, a nanoplatform consisting of FA-Fe 3 O 4 @mSiO 2 -Au/DOX was constructed. Methods: In vitro, the nanoplatform catalyzed NO's release with the maximum value of 4.91 μM within 60 min at 43°C pH=5.0, which was increased by 1.14 times when the temperature was 37°C. In vivo, 11.7 μg Au in the tumor tissue was found to catalyze S-nitrosoglutathione continuously, and 54 μM NO was checked out in the urine. Results and Discussion: The high concentration of NO was found to increase the apoptotic rate and to reduce tumor proliferation. In the chemo-photothermal combination therapy, the tumor inhibition rate was increased up to 94.3%, and Au's contribution from catalyzing NO release NO was 8.17%.

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“…Johnson et al have proved by experiments and simulation that the heating ability is related to the volume of the nanoparticles, rather than the absorptivity of the particles. This dependence is associated to the fact that particles with larger heat capacities can heat larger volumes of their surrounding media for larger periods [25].…”

Section: Photothermal Properties Of Ionsmentioning

confidence: 99%

“…It was demonstrated that the greatest part of the heat generated by magnetite nanoparticles was effectively dissipated to the surroundings without producing significant undesirable changes of the particles such as crystalline phase transitions, agglomeration or fragmentation [24]. Recently, the photothermal effectiveness of IONs has been proved to depend on particle size: The effectiveness shows a good correlation with particle volume [25]. Several works using aggregated or individual IONs as PA in the first biological window have been described [26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Superparamagnetic Nanoparticles with Efficient Near-Infrared Photothermal Effect at the Second Biological Window

et al. 2020

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Superparamagnetic nanoparticles (iron oxide nanoparticles—IONs) are suitable for hyperthermia after irradiating with radiofrequency radiation. Concerning the suitability for laser ablation, IONs present a low molar absorption coefficient in the near-infrared region close to 800 nm. For this reason, they are combined with other photothermal agents into a hybrid composite. Here, we show that IONs absorb and convert into heat the infrared radiation characteristic of the so-called second-biological window (1000–1350 nm) and, in consequence, they can be used for thermal ablation in such wavelengths. To the known excellent water solubility, colloidal stability and biocompatibility exhibited by IONs, an outstanding photothermal performance must be added. For instance, a temperature increase of 36 °C was obtained after irradiating at 8.7 W cm−2 for 10 min a suspension of IONs at iron concentration of 255 mg L−1. The photothermal conversion efficiency was ~72%. Furthermore, IONs showed high thermogenic stability during the whole process of heating/cooling. To sum up, while the use of IONs in the first bio-window (700–950 nm) presents some concerns, they appear to be good photothermal agents in the second biological window.

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Photothermal Effectiveness of Magnetite Nanoparticles: Dependence upon Particle Size Probed by Experiment and Simulation

Cited by 27 publications

References 39 publications

Iron Oxide Nanoparticles in Photothermal Therapy

Iron Oxide Nanoparticles in Photothermal Therapy

Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy

Superparamagnetic Nanoparticles with Efficient Near-Infrared Photothermal Effect at the Second Biological Window

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