Photothermal-pH-hypoxia responsive multifunctional nanoplatform for cancer photo-chemo therapy with negligible skin phototoxicity

Chen, Dapeng; Tang, Yaning; Zhu, Jiawei; Zhang, Jiaojiao; Song, Xuejiao; Wang, Wenjun; Shao, Jinjun; Huang, Wei; Peng, Chen; Dong, Xiaochen

doi:10.1016/j.biomaterials.2019.119422

Cited by 108 publications

(55 citation statements)

References 49 publications

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“…[9] However, the efficiency of PDT or PTT alone is usually unsatisfactory because of the hypoxic nature of tumor microenvironment for PDT and acquired heat shock effect in PTT. [10,11] The cooperation of PDT and PTT is considered as a groundbreaking tactic to surmount respective drawbacks and achieve synergistic effects with boosted therapeutic outcomes. [12,13] For instance, PTT could improve the oxygen supply in the tumor tissue through raising the blood flow rate, thus promoting the PDT effect, which conversely further eliminates the heat-resistant tumor cells in PTT.…”

Section: To the Best Of The Knowledge There Have Been No Previous Rementioning

confidence: 99%

An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

et al. 2020

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Aiming to achieve versatile phototheranostics with the integrated functionalities of multiple diagnostic imaging and synergistic therapy, the optimum use of dissipated energy through both radiative and nonradiative pathways is definitely appealing, yet a significantly challenging task. To the best of the knowledge, there have been no previous reports on a single molecular species effective at affording all phototheranostic modalities including fluorescence imaging (FLI), photoacoustic imaging (PAI), photothermal imaging (PTI), photodynamic therapy (PDT), and photothermal therapy (PTT). Herein, a simple and highly powerful one‐for‐all phototheranostics based on aggregation‐induced emission (AIE)‐active fluorophores is tactfully designed and constructed. Thanks to its strong electron donor–acceptor interaction and finely modulated intramolecular motion, the AIE fluorophore‐based nanoparticles simultaneously exhibit bright near‐infrared II (NIR‐II) fluorescence emission, efficient reactive oxygen species generation, and high photothermal conversion efficiency upon NIR irradiation, indicating the actualization of a balance between radiative and nonradiative energy dissipations. Furthermore, the unprecedented performance on NIR‐II FLI‐PAI‐PTI trimodal‐imaging‐guided PDT–PTT synergistic therapy is demonstrated by the precise tumor diagnosis and complete tumor elimination outcomes. This study thus brings a new insight into the development of superior versatile phototheranostics for practical cancer theranostics.

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Section: To the Best Of The Knowledge There Have Been No Previous Rementioning

confidence: 99%

An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

et al. 2020

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“…However, external stimuli (e.g., light) are usually used to trigger the release of payload, which may not be always practical or convenient for use under conditions lack of relevant clinic settings or incompatible with the stimuli (e.g., limited penetration depth of light for tumors deeply trapped in viscera or other important tissues). The design of hybrid nanovesicles that are responsive to internal pathological features of tumors (such as hypoxia 39 , high glutathione (GSH) 40 - 43 , acid microenvironment 44 - 50 , elevated level of reactive oxygen species (ROS) 51 - 55 , high glucose 15 level etc.) offers a promising route to overcome the limitations of photo-based therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Tang

et al. 2020

Theranostics

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Rationale: Nanoscale vehicles responsive to abnormal variation in tumor environment are promising for use in targeted delivery of therapeutic drugs specifically to tumor sites. Herein, we report the design and fabrication of self-accelerating H 2 O 2 -responsive plasmonic gold nanovesicles (GVs) encapsulated with tirapazamine (TPZ) and glucose oxidase (GOx) for synergistic chemo/starving therapy of cancers. Methods: Gold nanoparticles were modified with H 2 O 2 -responsive amphiphilic block copolymer PEG 45 - b -PABE 330 by ligand exchange. The TPZ and GOx loaded GVs (TG-GVs) were prepared through the self-assembly of PEG 45 - b -PABE 330 -grafted nanoparticles together with TPZ and GOx by solvent displacement method. Results: In response to H 2 O 2 in tumor, the TG-GVs dissociate to release the payloads that are, otherwise, retained inside the vesicles for days without noticeable leakage. The released GOx enzymes catalyze the oxidation of glucose by oxygen in the tumor tissue to enhance the degree of hypoxia that subsequently triggers the reduction of hypoxia-activated pro-drug TPZ into highly toxic free radicals. The H 2 O 2 generated in the GOx-catalyzed reaction also accelerate the dissociation of vesicles and hence the release rate of the cargoes in tumors. The drug-loaded GVs exhibit superior tumor inhibition efficacy in 4T1 tumor-bearing mice owing to the synergistic effect of chemo/starvation therapy, in addition to their use as contrast agents for computed tomography imaging of tumors. Conclusion: This nanoplatform may find application in managing tumors deeply trapped in viscera or other important tissues that are not compatible with external stimulus (e.g. light).

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“…Different from above photothermal responsive liposomes, Dong’s group recently developed a photothermal-pH-hypoxia multi-responsive liposome for synergistic cancer PTT/PDT/chemotherapy with negligible skin phototoxicity [ 63 ]. Such a multi-stimuli responsive liposome consisted of an eutectic PCM mixture of linoleic acid and stearyl alcohol with a melting point at around 43.9 °C, cell-penetrating peptide (CPP, YGRKKRRQRRR) modified DSPE-PEG, DSPE-PEG, a diethylamino group-flanked aza-BODIPY derivative (ENAB) as the pH-responsive photosensitizer, and a hypoxia-specific prodrug, tirapazamine (TPZ).…”

Section: Photothermal Responsive Ddssmentioning

confidence: 99%

Section: Photothermal Responsive Ddssmentioning

confidence: 99%

Near-infrared photoresponsive drug delivery nanosystems for cancer photo-chemotherapy

et al. 2020

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Drug delivery systems (DDSs) based on nanomaterials have shown a promise for cancer chemotherapy; however, it remains a great challenge to localize on-demand release of anticancer drugs in tumor tissues to improve therapeutic effects and minimize the side effects. In this regard, photoresponsive DDSs that employ light as an external stimulus can offer a precise spatiotemporal control of drug release at desired sites of interest. Most photoresponsive DDSs are only responsive to ultraviolet-visible light that shows phototoxicity and/or shallow tissue penetration depth, and thereby their applications are greatly restricted. To address these issues, near-infrared (NIR) photoresponsive DDSs have been developed. In this review, the development of NIR photoresponsive DDSs in last several years for cancer photo-chemotherapy are summarized. They can achieve on-demand release of drugs into tumors of living animals through photothermal, photodynamic, and photoconversion mechanisms, affording obviously amplified therapeutic effects in synergy with phototherapy. Finally, the existing challenges and further perspectives on the development of NIR photoresponsive DDSs and their clinical translation are discussed.

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Photothermal-pH-hypoxia responsive multifunctional nanoplatform for cancer photo-chemo therapy with negligible skin phototoxicity

Cited by 108 publications

References 49 publications

An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Near-infrared photoresponsive drug delivery nanosystems for cancer photo-chemotherapy

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Photothermal-pH-hypoxia responsive multifunctional nanoplatform for cancer photo-chemo therapy with negligible skin phototoxicity

Cited by 108 publications

References 49 publications

An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

Self-accelerating H2O2-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Near-infrared photoresponsive drug delivery nanosystems for cancer photo-chemotherapy

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Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors