Photothermal synergistic nitric oxide controlled release injectable self-healing adhesive hydrogel for biofilm eradication and wound healing

Abstract

A novel injectable self-healing adhesive hydrogel with specific bacteria capture capability and inherent contact antimicrobial activity for mild photothermal therapy and NO controlled release to synergically eliminate biofilm infections and promote wound healing.

Advancements and Challenges in Self-Healing Hydrogels for Wound Care

“…The application of borate and boronic ester bonds introduces dynamic covalent chemistry to hydrogel networks, enabling self-healing capabilities through reversible bonding. These bonds are instrumental in the development of pH-responsive hydrogels that adeptly adjust to the varying conditions of wound environments [46,63,70,[97][98][99][100][101].…”

“…FHE hydrogels with stimuli-responsive exosome release have shown promise in enhancing chronic wound healing and skin regeneration [118]. Hydrogels with photothermal and nitric oxide-controlled release have been designed for flexibility, tissue adhesion and accelerated wound healing, alongside biofilm eradication [100].…”

“…Electrical conductivity, antioxidant activity, slow and pH-responsive TOB release, in vitro and in vivo antibacterial activity, NIR irradiation assisted bactericidal activity, PA-infected burn wound inflammation control and healing promotion [91] Quaternization chitosan derivatives with phenylboronic acid and catechol-like moieties, BNN6-loaded mesoporous polydopamine (MPDA@BNN6 NPs) Injectability, flexibility, rapid self-healing, bacterial affinity, tissue adhesion, antioxidant stress ability, in vivo S. aureus biofilm eradication, infected wound repair acceleration [100] Polyvinyl alcohol (PVA) and hyaluronic acid grafted with phenylboronic acid (BA-HA), polydopamine, and gelatin microspheres containing basic fibroblast growth factor (GMs@bFGF) Shape-adaptation, strong adhesion, instantaneous self-healing, controlled bFGF release, promotion of tendon wound healing through alleviation of inflammation and collagen I secretion [101] Quaternized N- [3-(dimethylamino)propyl] methacrylamide with dithiodipropionic acid dihydrazide Efficient self-healing capability, pH and redox-triggered gel-sol-gel transition, good antibacterial activity, biocompatibility, degradability, sustained release ability, in vivo experiments for wound closure and cutaneous regeneration [102] Quaternary ammonium chitosan (QCS)/tannic acid (TA) hydrogel Injectability, self-healing, adhesive properties, reactive oxygen species scavenging, broad-spectrum antibacterial ability, rapid hemostatic capability, in vivo hemostasis, wound-healing acceleration [105] Poly(ethylene glycol)-co-poly(sorbitol sebacate) conjugated with chitosan-g-poly tetraaniline (QCS-g-PTA)…”

“…The shift toward developing materials and hydrogel formulations tailored to individual medical needs and patient conditions represents a significant move toward personalized medicine. By customizing these materials [1,5,7,10,13,15,16,18,29,32,41,51,57,63,100,104,108,115], the aim is to improve therapeutic outcomes for various wound types or diseases, integrating smart functionalities for dynamic response and real-time health monitoring. This approach emphasizes the necessity for precision in treatments and the potential to substantially enhance patient care.…”

A bioinspired injectable antioxidant hydrogel for prevention of postoperative adhesion

“…Hydrogels have attracted considerable attention in the medical field due to their developing properties such as biodegradability, 11–13 biocompatibility, 14–18 injectability, 19–22 self-healing properties, 23–27 and tissue repair capabilities. 28–32 Among the various hydrogels, polyurethane-based hydrogels have exhibited exceptional performance.…”