Photothermally enhanced photodynamic therapy based on mesoporous Pd@Ag@mSiO2 nanocarriers

Shi, Saige; Zhu, Xianglong; Zhao, Zengxia; Fang, Weijun; Chen, Mei; Huang, Yizhuan; Chen, Xiaolan

doi:10.1039/c2tb00376g

Cited by 63 publications

(52 citation statements)

References 45 publications

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“…Drug carrier by pore structure and release by photothermal conversion FePt [109] Gene delivery by functionalized surface AuNi [83] Drug delivery by pore structure AuPt [95] Photothermally enhanced photodynamic therapy PdAg [118,189] In addition to photothermal treatments, another class of hyperthermia treatment is magnetic hyperthermia-a therapy that depends on magnetic nanomaterials that can be selectively positioned near target cells and generate localized heat when exposed to an alternating external magnetic field.…”

Section: Drug Deliverymentioning

confidence: 99%

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

et al. 2018

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Metal nanoparticles are extensively studied due to their unique chemical and physical properties, which differ from the properties of their respective bulk materials. Likewise, the properties of heterogeneous bimetallic structures are far more attractive than those of single-component nanoparticles. For example, the incorporation of a second metal into a nanoparticle structure influences and can potentially enhance the optical/plasmonic and magnetic properties of the material. This review focuses on the enhanced optical/plasmonic and magnetic properties offered by bimetallic nanoparticles and their corresponding impact on biological applications. In this review, we summarize the predominant structures of bimetallic nanoparticles, outline their synthesis methods, and highlight their use in biological applications, both diagnostic and therapeutic, which are dictated by their various optical/plasmonic and magnetic properties.

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Section: Drug Deliverymentioning

confidence: 99%

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

et al. 2018

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“…In this regard, converting the visible wavelength to NIR light is mandatory for PDT using MB. Nevertheless, relatively little research has been conducted in this direction, in contrast to the voluminous existing database on photosensitizer-incorporated multifunctional nanoparticles for cancer theranostics [23,24]. Hybridization with GNRs could solve the limitations of MB-based PDT therapy because the NIR light facilitates electron transfer from the GNRs to the MB molecules.…”

Section: Introductionmentioning

confidence: 99%

NIR-light-induced surface-enhanced Raman scattering for detection and photothermal/photodynamic therapy of cancer cells using methylene blue-embedded gold nanorod@SiO2 nanocomposites

et al. 2014

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Methylene blue-loaded gold nanorod@SiO2 (MB-GNR@SiO2) core@shell nanoparticles are synthesized for use in cancer imaging and photothermal/photodynamic dual therapy. For the preparation of GNR@SiO2 nanoparticles, we found that the silica coating rate of hexadecylcetyltrimethylammonium bromide (CTAB)-capped GNRs is much slower than that of PEGylated GNRs due to the densely coated CTAB bilayer. Encapsulated MB molecules have both monomer and dimer forms that result in an increase in the photosensitizing effect through different photochemical pathways. As a consequence of the excellent plasmonic properties of GNRs at near-infrared (NIR) light, the embedded MB molecules showed NIR light-induced SERS performance with a Raman enhancement factor of 3.0 × 1010, which is enough for the detection of a single cancer cell. Moreover, the MB-GNR@SiO2 nanoparticles exhibit a synergistic effect of photodynamic and photothermal therapies of cancer under single-wavelength NIR laser irradiation.

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“…It is well-established that mesoporous silica can be coated onto the surface of various inorganic nanocrystals for realizing functionalizations of MSNs, such as Fe 3 O 4 @mSiO 2 , [152][153][154] Au@ mSiO 2 , [ 155 ] Pd/Ag@mSiO 2 , [ 156 ] graphene@mSiO 2 , [ 157 ] MnO@ mSiO 2 , [ 158,159 ] and UCNP@mSiO 2 . [ 160,161 ] Similar to the functionalization of MSNs, Janus UCNP@SiO 2 @mSiO 2 &PMOs NPs were synthesized by an anisotropic island nucleationand-growth approach.…”

Section: Functionalization Of Monsmentioning

confidence: 99%

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

2016

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Organic-inorganic hybrid materials aiming to combine the individual advantages of organic and inorganic components while overcoming their intrinsic drawbacks have shown great potential for future applications in broad fields. In particular, the integration of functional organic fragments into the framework of mesoporous silica to fabricate mesoporous organosilica materials has attracted great attention in the scientific community for decades. The development of such mesoporous organosilica materials has shifted from bulk materials to nanosized mesoporous organosilica nanoparticles (designated as MONs, in comparison with traditional mesoporous silica nanoparticles (MSNs)) and corresponding applications in nanoscience and nanotechnology. In this comprehensive review, the state-of-art progress of this important hybrid nanomaterial family is summarized, focusing on the structure/composition-performance relationship of MONs of well-defined morphology, nanostructure, and nanoparticulate dimension. The synthetic strategies and the corresponding mechanisms for the design and construction of MONs with varied morphologies, compositions, nanostructures, and functionalities are overviewed initially. Then, the following part specifically concentrates on their broad spectrum of applications in nanotechnology, mainly in nanomedicine, nanocatalysis, and nanofabrication. Finally, some critical issues, presenting challenges and the future development of MONs regarding the rational synthesis and applications in nanotechnology are summarized and discussed. It is highly expected that such a unique molecularly organic-inorganic nanohybrid family will find practical applications in nanotechnology, and promote the advances of this discipline regarding hybrid chemistry and materials.

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Photothermally enhanced photodynamic therapy based on mesoporous Pd@Ag@mSiO2 nanocarriers

Cited by 63 publications

References 45 publications

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

NIR-light-induced surface-enhanced Raman scattering for detection and photothermal/photodynamic therapy of cancer cells using methylene blue-embedded gold nanorod@SiO2 nanocomposites

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

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