Photothermic therapy with cuttlefish ink-based nanoparticles in combination with anti-OX40 mAb achieve remission of triple-negative breast cancer

Momenzadeh, Niloofar; Hajian, Sobhan; Shabankare, Atefe; Ghavimi, Reza; Kabiri-Samani, Saber; Kabiri, Hamidreza; Hesamizadeh, Khashayar; Shabankareh, Azar Najafi Tireh; Nazaraghay, Roghayeh; Nabipour, Iraj; Mohammadi, Mohsen

doi:10.1016/j.intimp.2022.109622

Cited by 7 publications

(5 citation statements)

References 38 publications

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“…Anti-OX40 mAbs were i.t. delivered on day 10 and 11 post-4T1 tumor implantation in a murine model, which directly followed two consecutive days of administration of cuttlefish ink-based NPs, which are natural photothermal agents that have also immune activity ( 72 ). Treatment delayed tumor growth, while also inhibiting lung metastasis, reducing splenomegaly, increasing activated IFNγ+ CD4+ and CD8+ splenocytes, and increasing tumor infiltrating CD8+ T cells ( 72 ).…”

Section: Preclinical Studiesmentioning

confidence: 99%

“…Anti-tumor effects in un-injected, abscopal tumors were observed with the adenovirus Ad-RTA-hIL-12 ( 51 ), and adenovirus CAdVEC ( 60 , 61 ) in clinical studies. Preclinical treatments with antibodies, cells, viruses, cytokines, and innate immune agonists reduced or eliminated metastases ( 72 , 75 – 77 , 92 , 94 , 99 , 100 , 110 , 118 , 120 , 121 , 127 , 129 , 132 , 135 , 136 , 138 , 140 , 145 ) and induced systemic anti-tumor effect in untreated tumors ( 79 , 119 , 130 , 131 , 133 – 135 ). Furthermore, i.t.…”

Section: Key Findingsmentioning

confidence: 99%

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Intratumoral delivery of immunotherapy to treat breast cancer: current development in clinical and preclinical studies

Mantooth,

Abdou,

Saez-Ibañez

et al. 2024

Front. Immunol.

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Breast cancer poses one of the largest threats to women’s health. Treatment continues to improve for all the subtypes of breast cancer, but some subtypes, such as triple negative breast cancer, still present a significant treatment challenge. Additionally, metastasis and local recurrence are two prevalent problems in breast cancer treatment. A newer type of therapy, immunotherapy, may offer alternatives to traditional treatments for difficult-to-treat subtypes. Immunotherapy engages the host’s immune system to eradicate disease, with the potential to induce long-lasting, durable responses. However, systemic immunotherapy is only approved in a limited number of indications, and it benefits only a minority of patients. Furthermore, immune related toxicities following systemic administration of potent immunomodulators limit dosing and, consequently, efficacy. To address these safety considerations and improve treatment efficacy, interest in local delivery at the site of the tumor has increased. Numerous intratumorally delivered immunotherapeutics have been and are being explored clinically and preclinically, including monoclonal antibodies, cellular therapies, viruses, nucleic acids, cytokines, innate immune agonists, and bacteria. This review summarizes the current and past intratumoral immunotherapy clinical landscape in breast cancer as well as current progress that has been made in preclinical studies, with a focus on delivery parameters and considerations.

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Section: Preclinical Studiesmentioning

confidence: 99%

Section: Key Findingsmentioning

confidence: 99%

Intratumoral delivery of immunotherapy to treat breast cancer: current development in clinical and preclinical studies

Mantooth,

Abdou,

Saez-Ibañez

et al. 2024

Front. Immunol.

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“…Among cephalopod discards, ink sacs are commonly removed manually and thrown without appropriate management. However, recent studies on this kind of discard have revealed several beneficial properties regarding human health [5][6][7], cosmetic purposes [8], and environmental preservation [9]. Regarding the preservation of seafood, previous studies have shown relevant antimicrobial [10] and antioxidant [11][12][13] properties of cephalopod ink extracts when applied to different kinds of seafood substrates.…”

Section: Introductionmentioning

confidence: 99%

Preservative Effect of a Cuttlefish Ink Extract on Canned Golden Seabream (<em>Sparus aurata</em>)

Martínez,

Trigo,

Aubourg

2024

Preprint

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Among cephalopod discards, ink has revealed several beneficial properties regarding human health, environmental preservation and food preservation. In this study, different concentrations of an aqueous extract of cuttlefish (Sepia spp.) ink (CI) were added, respectively, to the packing medium employed during golden seabream (Sparus aurata) canning. Quality parameters of the resulting canned fish were determined and compared to the counterpart control and raw samples. As a result, an important effect of the CI concentration added to the packing medium was proved. The presence in the packing medium of a relatively low CI concentration led to lower (p&lt;0.05) lipid oxidation development (fluorescent compound formation), lower (p&lt;0.05) changes of colour parameters (L* and a* values) and lower (p&lt;0.05) trimethylamine values in canned fish. Additionally, the two lowest CI concentrations tested led to higher average values of C22:6ω3 and ω3/ω6 ratios. Remarkably, higher average values of free fatty acids, polyene index and C20:5ω3 were detected in all kinds of CI-treated fish when compared to control canned samples. In agreement with environmental sustainability and circular economy requirements, the study provides a first approach to a novel and beneficial use of the present marine discard for the quality enhancement of canned fish.

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“…Among cephalopod discards, ink sacs are generally discarded and thrown without appropriate management. Nevertheless, recent studies carried out on this byproduct have indicated several beneficial properties regarding human health [ 5 , 6 , 7 ], cosmetic purposes [ 8 ], and environmental sustainability [ 9 ]. Regarding seafood preservation, previous research has shown relevant antimicrobial [ 10 , 11 ] and antioxidant [ 12 , 13 , 14 , 15 ] properties of cephalopod-ink extracts when used in the preparation of seafood substrates.…”

Section: Introductionmentioning

confidence: 99%

Influence of Cuttlefish-Ink Extract on Canned Golden Seabream (Sparus aurata) Quality

Martínez,

Trigo,

Rodríguez

et al. 2024

Foods

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Four different concentrations of an aqueous extract of cuttlefish (Sepia spp.) ink (CI) were introduced, respectively, into the packing medium employed during golden seabream (Sparus aurata) canning. The quality parameters of the resulting canned fish were determined and compared to the initial fish and the control canned muscle. An important effect of the CI concentration introduced in the packing medium was proved. The presence in the packing medium of a relatively low CI concentration (CI-2 batch) led to a lower (p < 0.05) lipid oxidation development (fluorescent compound formation), lower (p < 0.05) changes of colour parameters (L* and a* values), and lower (p < 0.05) trimethylamine values in canned fish when compared to control canned samples. Additionally, the two lowest CI concentrations tested led to higher average values of C22:6ω3, ω3/ω6 ratios, and polyene index. On the contrary, the use of the most concentrated CI extract (CI-4 condition) led to a prooxidant effect (higher fluorescence ratio value). In agreement with environmental sustainability and circular economy requirements, the study can be considered the first approach to a novel and valuable use of the current marine byproduct for the quality enhancement of canned fish. On-coming research focused on the optimisation of the CI-extract concentration is envisaged.

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Photothermic therapy with cuttlefish ink-based nanoparticles in combination with anti-OX40 mAb achieve remission of triple-negative breast cancer

Cited by 7 publications

References 38 publications

Intratumoral delivery of immunotherapy to treat breast cancer: current development in clinical and preclinical studies

Intratumoral delivery of immunotherapy to treat breast cancer: current development in clinical and preclinical studies

Preservative Effect of a Cuttlefish Ink Extract on Canned Golden Seabream (<em>Sparus aurata</em>)

Influence of Cuttlefish-Ink Extract on Canned Golden Seabream (Sparus aurata) Quality

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