Phototoxicity of CdSe/ZnSe quantum dots with surface coatings of 3-mercaptopropionic acid or tri-n-octylphosphine oxide/gum arabic in Daphnia magna under environmentally relevant UV-B light

Kim, Jungkon; Park, Yena; Yoon, Tae Hyun; Yoon, Chung Sik; Choi, Kyungho

doi:10.1016/j.aquatox.2009.12.022

Cited by 67 publications

(34 citation statements)

References 39 publications

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“…The study proposed that CdS quantum dots' cytotoxicity is mediated by intracellular ROS production, cadmium ions (Cd 2+ ) release and GSH depletion [204]. Quantum dots are responsible for phototoxicity in Daphnia magna under UV-B light [205]. In vivo studies suggested that fullerenes are responsible for elevated gene expression of MHC class II molecules, increased proinflammatory cytokines and increased T cell distribution in lungs [142,[206][207][208][209][210].…”

Section: Mechanistic Studiesmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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Section: Mechanistic Studiesmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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“…The spectrum of QDs was distinct from that of D. magna and no interference was observed. 44,45 rOs and antioxidant enzyme analysis…”

Section: Uptake Experiments On D Magnamentioning

confidence: 99%

<em>Daphnia magna</em> and<em> Xenopus laevis</em> as in vivo models to probe toxicity and uptake of quantum dots functionalized with gH625

Galdiero¹,

Falanga²,

Siciliano³

et al. 2017

IJN

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The use of quantum dots (QDs) for nanomedicine is hampered by their potential toxicologic effects and difficulties with delivery into the cell interior. We accomplished an in vivo study exploiting Daphnia magna and Xenopus laevis to evaluate both toxicity and uptake of QDs coated with the membranotropic peptide gH625 derived from the glycoprotein H of herpes simplex virus and widely used for drug delivery studies. We evaluated and compared the effects of QDs and gH625-QDs on the survival, uptake, induction of several responsive pathways and genotoxicity in D. magna , and we found that QDs coating plays a key role. Moreover, studies on X. laevis embryos allowed to better understand their cell/tissue localization and delivery efficacy. X. laevis embryos raised in Frog Embryo Teratogenesis Assay- Xenopus containing QDs or gH625-QDs showed that both nanoparticles localized in the gills, lung and intestine, but they showed different distributions, indicating that the uptake of gH625-QDs was enhanced; the functionalized QDs had a significantly lower toxic effect on embryos’ survival and phenotypes. We observed that D. magna and X. laevis are useful in vivo models for toxicity and drug delivery studies.

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“…Jeong et al 17 showed that NPs could actually penetrate into the stratum corneum of in vivo human skin. Recent papers have demonstrated that quantum dot NPs induce phototoxicity in Daphnia magna after exposure to UVB and that fullerene NPs cause phototoxic damage in retinal pigment epithelial cells after exposure to UV or visible light [18][19][20] . However, limited literature has reported on the phototoxicity potential of NPs.…”

Section: Assessment Of Phototoxicity Of Nanosilicamentioning

confidence: 99%

A safety assessment of phototoxicity and sensitization of SiO2 nanoparticles

Choi

Park

Lee

et al. 2011

Mol. Cell. Toxicol.

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Despite widespread use of silicon dioxide (SiO 2 ) NPs in industry and in our daily lives, no studies so far have evaluated the potential of their skin phototoxicity and sensitization. This study was designed to investigate the potential of phototoxicity and sensitization of SiO 2 NPs. Assessment of the potential of skin phototoxicity was carried out using the 3T3 neutral red uptake test, an HSEM, and an animal model. The potential of skin sensitization was evaluated by a non-radioisotope local lymph node assay (non-RI LLNA). Findings from the present study suggest that the HSEM may be a reasonable model system for evaluation of skin phototoxicity of NPs. In addition, our data demonstrate that non-RI LLNA may be a useful method for identification of skin sensitization of NPs. In this study, we showed that SiO 2 NPs do not induce phototoxicity or skin sensitization.

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Phototoxicity of CdSe/ZnSe quantum dots with surface coatings of 3-mercaptopropionic acid or tri-n-octylphosphine oxide/gum arabic in Daphnia magna under environmentally relevant UV-B light

Cited by 67 publications

References 39 publications

In vitro and in vivo toxicity assessment of nanoparticles

In vitro and in vivo toxicity assessment of nanoparticles

<em>Daphnia magna</em> and<em> Xenopus laevis</em> as in vivo models to probe toxicity and uptake of quantum dots functionalized with gH625

A safety assessment of phototoxicity and sensitization of SiO2 nanoparticles

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