Phototoxicity of <i>Heracleum laciniatum</i>

Kavli, G; Volden, G; Middlefart, K.; Haugsbø, S.; Prytz, Jan

doi:10.1111/j.1600-0536.1983.tb04622.x

Cited by 10 publications

(7 citation statements)

References 12 publications

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“…More than 150 compounds have been isolated from plants mainly belonging to the families of Rutaceae and Umbelliferae, comprising common edible vegetables and fruits such as lemons, oranges, and grapefruits [184,185]. Phototoxic furocoumarins such as xanthotoxin (8-MOP) or bergapten have been isolated from the Umbelliferae, Moraceae, Leguminosae, Rosaceae, and Compositae plant families [186]. The photoreactivity of the plants depends on their furocoumarins (psoralens) content.…”

Section: Terrestrial Cyclobutane-containing Alkaloidsmentioning

confidence: 99%

“…Their structures are shown in Fig. 56 (185)(186)(187)(188) Antidepolarizing agents anatruxonium (199), truxillonium (200), pyrocyclonium (201), and cyclobutonium (202) have been synthesized and their biological activities reported [261][262][263]. In rabbits, cats, chicks, and guinea pigs, the four compounds possess high curarelike properties.…”

Section: Synthetic Analogs Of Natural Alkaloids With Cyclobutane Ringmentioning

confidence: 99%

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Bioactive cyclobutane-containing alkaloids

2007

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The present review describes research on novel natural cyclobutane-containing alkaloids and synthetic compounds isolated from terrestrial and marine species. More than 210 compounds have been confirmed to show antimicrobial, antibacterial, anticancer, and other activities. Structures, origins, biosynthesis, photodimerization, and biological activities of a selection of cyclobutane-containing alkaloids and selected synthetic analogs of natural alkaloids are reviewed.

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Section: Terrestrial Cyclobutane-containing Alkaloidsmentioning

confidence: 99%

Section: Synthetic Analogs Of Natural Alkaloids With Cyclobutane Ringmentioning

confidence: 99%

Bioactive cyclobutane-containing alkaloids

2007

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“…The usage of oral khella as a therapy is not as safe as it might sound and limited by its potential cytotoxicity. [24][25][26][27][28] In humans, two studies have been conducted; the first investigated the utilization of oral khellin to reduce blood lipids and the second studiedthe effects of khellin in vitiligo. 24,25 Researchers observed that gastro-intestinal side-effects were observed frequently (29% of patients in the vitiligo study) and, elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were also reported during therapy (7% to 14%).…”

Section: Discussionmentioning

confidence: 99%

“…The furocoumarins (psoralens) found in khella plant may cause photosensitization and dermatitis. 26 One study reported fourirritant active ingredients from khella seeds and investigatedthe mechanism of action of their potential contact dermatitis. 28 A case report described a case withallergic rhinitis and contact urticaria as a result of exposure to khella during cultivation in a florist shop.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2020

UNOAJ

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Khella (Ammi visnagais) was used in Ancient Egypt as a herbal remedy for renal colic. Khella contains group of coumarins, xanthotoxin, ammidin, furoquinoline alkaloids and, dihydroseselins with varying cytotoxic activity. The most common is Khellin and visnagin. Khellin was found to be a smooth muscle relaxant, induces diuresis, increases excretion of citrate and decreases the excretion of oxalate in urine, which improves nephrolithiasis and passage of ureteric stones. Synthetic derivatives of khellin include amiodarone, the antiarrhythmic drug, and cromolyn, an anti-asthma drug. Khellin is not as safe as it seems to be. Its oral use is limited by its potential toxicity (eg, elevated liver enzymes, phototoxicity, dermatitis). In experimental animals, the median lethal dose (LD50) was 3.6 g/kg for intraperitoneal administration and 10.1 g/kg for oral administration. In humans, nausea and vomiting were observed frequently in 29% and transaminitis in 7-14% of the patients. Other potential adverse reactions include dizziness, constipation, headache, itching, insomnia, photosensitivity and lack of appetite. We report for the first-time, acute kidney injury following use of khella in a CKD patient with a 5-fold increase in his serum creatinine level from 1.9 to 9.2 mg/dl. His renal biopsy revealed eosinophilic interstitial nephritis. He responded well to pulse methylprednisolone followed by short course of oral steroids. We believe this is the first case describing Khella nephropathy. Herbal nephropathy is not uncommon and herbal remedies are not as safe as it is believed. Accurate diagnosis and early management are the key in improving the renal outcome.

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“…It was responsible of a dermal-epidermal cleavage, leading to apparition of vesicles and bullae. Two other cases of phytophotodermatitis by using Ammi majus L. were reported in literature [1][2][3][4]. Other authors described cases of urticaria, allergic rhinitis and ocular toxicity after the use of this plant [5].…”

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confidence: 99%