Phrenic nerve conduction in the early stage of Guillain?Barre syndrome might predict the respiratory failure

Abstract

Our findings showed that not only delayed distal latency but also decreased amplitude may predict the need for respiratory assistance during the subsequent disease course.

Phrenic nerve conduction study in the early stage of guillain–barre syndrome as a predictor of respiratory failure

“…Clinical assessment and vital capacity measurements, though useful, are not sensitive enough to detect ventilation failure in the early stages as found in Ito et al . 's study[ 10 ] where clinical assessment was not correlated with phrenic nerve conduction or subsequent respiratory failure, but phrenic nerve conduction studies were proportional to measurements of respiratory functions such as vital capacity and provided the earliest indicator of involvement of respiratory muscles. [ 20 21 ]…”

“…In a study by Ito et al .,[ 10 ] all patients with a sum of phrenic nerve latency longer than 30 ms and the sum of the bilateral diaphragmatic CMAP amplitude <0.3 mV required respiratory assistance during the hospital stay.…”

“…Only a few studies have evaluated the role of electrophysiology of the phrenic nerve in early stage of GBS patients to detect respiratory failure,[ 9 ] and clinical assessment was not correlated with subsequent respiratory failure; however, phrenic nerve conduction studies were proportional to measurements of respiratory functions. [ 10 ]…”

Neurally Adjusted Ventilatory Assist During Weaning From Respiratory Support in a Case of Guillain-Barré Syndrome

“…6 Electrophysiological studies at the early stage of Guillain-Barré syndrome have documented prolonged phrenic nerve latency. 7,8 In addition, diaphragmatic compound muscle action potential latencies, amplitude, and duration are significantly different between Guillain-Barré syndrome patients with and without respiratory failure. 9,10 Although phrenic nerve conduction time improves over time (often several weeks), this electrophysiological recording cannot be used to predict weaning from mechanical ventilation, as full clinical recovery usually precedes electrophysiological recovery.…”

Urgencias en patología neuromuscular

“…En el SGB, una de las principales causas de IR es la debilidad del diafragma; el estudio de velocidad de conducción del nervio frénico y registro del potencial de acción diafragmático realizado en los primeros días del inicio clínico pueden ser útiles para predecir fallo respiratorio y necesidad de intubación 28 .…”