2023
DOI: 10.3389/fphys.2023.1182505
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Phrenic nerve stimulation mitigates hippocampal and brainstem inflammation in an ARDS model

Abstract: Rationale: In porcine healthy-lung and moderate acute respiratory distress syndrome (ARDS) models, groups that received phrenic nerve stimulation (PNS) with mechanical ventilation (MV) showed lower hippocampal apoptosis, and microglia and astrocyte percentages than MV alone.Objectives: Explore whether PNS in combination with MV for 12 h leads to differences in hippocampal and brainstem tissue concentrations of inflammatory and synaptic markers compared to MV-only animals.Methods: Compare tissue concentrations … Show more

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