PHS15 Recommendation for Rotavirus Vaccination and Herd Effect: Analyzing Cost Data from a German Statutory Health Insurance

Abstract

study design, number of covariates adjusted and adjusted for BMI and cardiovascular diseases. Subgroup and sensitivity analysis were also done. Heterogeneity and publication bias were also assessed. RESULTS: 24 studies were included in the analysis. The pooled risk ratio of PD due to hypertension (nϭ8) was 0.78 (95% CI, 0.67-0.92, I2ϭ71.85%), due to high serum cholesterol (nϭ7) was 0.95 (95% CI, 0.77-1.17, I2ϭ 75.86%), and due to diabetes (nϭ14) was 0.94 (95% CI, 0.76-1.16, I2ϭ 89.62%). Subgroup analysis showed a significant difference in effect estimate pooled by cohort and case-control studies (Pin-teractionϽ0.001). Pooled analysis of cohort studies for diabetes showed a pooled risk ratio of 1.34 (95%CI, 1.12-1.60, I2ϭ76.77%). We found no significant difference in any subgroup analysis. CONCLUSIONS: We found evidence of significant inverse associations of hypertension, hypercholesterolemia, and diabetes mellitus with the risk of PD. Further well-designed investigations of the association of vascular risk factors with the risk of PD are needed, particularly large-scale prospective studies.