1972
DOI: 10.1038/238411a0
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Phthalate Esters as Environmental Contaminants

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1973
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Cited by 303 publications
(106 citation statements)
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“…After 30 years of phtalate production, the toxic potential of these substances was recognized in the early 70's [5], but the actual growing problem is their potential activity as endocrine disrupting compounds (EDC) [6][7][8][9]; benzyl, butyl and di-n-butyl phtalates have been supposed EDC with estrogenic properties [10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…After 30 years of phtalate production, the toxic potential of these substances was recognized in the early 70's [5], but the actual growing problem is their potential activity as endocrine disrupting compounds (EDC) [6][7][8][9]; benzyl, butyl and di-n-butyl phtalates have been supposed EDC with estrogenic properties [10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…Concern about the identity of late eluting gas-liquid chromatographic (GLC) peaks in fish and water extracts led to the identification of phthalic acid esters (PAEs) as environmental contaminants (1). Further study of these contaminants with a GLC-mass spectrometer (GLC-MS) led to their identification as di-2-ethylhexyl phthalate (DEHP) and di-n-butyl phthalate (DBP).…”
mentioning
confidence: 99%
“…These esters have been detected in animals and humans. [2][3][4] We have reported that the administration of phthalic acid esters such as dibutylphtahlate 5,6) and DEHP [7][8][9][10][11][12] disturbed the metabolism of de novo NAD biosynthesis. Concretely, the administration of phthalic acid esters increased the formation of QA (a key intermediate of the de novo NAD biosynthesis) and its metabolites.…”
mentioning
confidence: 99%