Phthalate exposure and reproductive hormones and sex-hormone binding globulin before puberty – Phthalate contaminated-foodstuff episode in Taiwan

Wen, Hao; Chen, Chu-Chih; Wu, Ming-Tsang; Chen, Mei-Lien; Sun, Chien-Wen; Wu, Wen-Chiu; Huang, I-Wen; Huang, Po-Chin; Yu, Tzu-Yun; Hsiung, Chao A.; Wang, Shu Li

doi:10.1371/journal.pone.0175536

Cited by 36 publications

(29 citation statements)

References 44 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, in men with benign prostatic hyperplasia, estradiol levels, testosterone and steroidogenic enzymes aromatase, and 5α-reductase were increased [ 107 ]. Other studies observed associations between postnatal exposure to phthalates in healthy and infertile men and decreased testosterone [ 80 , 194 , 195 , 196 , 197 , 198 ]. Epidemiological studies yielded some conflicting results in the association between phthalate exposure and estradiol levels in men.…”

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

“…Phthalates act as the active hormonal agents in the organism. They can compete with natural hormones by binding to the transport globulin [ 172 , 196 ]. In silico studies observed that HMWP had a higher affinity to SHBG in comparison with LMWP.…”

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

“…The in silico study by Sheikh et al [ 214 ] showed that phthalates’ substituent DEHT had a higher affinity to SHBG as well. MEP, monobutyl phthalate (MBP), and MEHP were inversely associated with the levels of SHBG in boys [ 196 , 215 ]. MEHP was inversely associated with SHBG in boys.…”

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

“…MEHP was inversely associated with SHBG in boys. ∑DEHP was positively associated with the levels of SHBG in girls [ 196 ]. These studies support the anti-androgenic and pro-estrogenic effects of DEHP, MEP, and mono-n-butyl phthalate (MnBP) [ 196 , 215 ].…”

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

See 3 more Smart Citations

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Hlisníková

Petrovičová

Kolena

et al. 2020

IJERPH

163

View full text Add to dashboard Cite

The production of plastic products, which requires phthalate plasticizers, has resulted in the problems for human health, especially that of reproductive health. Phthalate exposure can induce reproductive disorders at various regulatory levels. The aim of this review was to compile the evidence concerning the association between phthalates and reproductive diseases, phthalates-induced reproductive disorders, and their possible endocrine and intracellular mechanisms. Phthalates may induce alterations in puberty, the development of testicular dysgenesis syndrome, cancer, and fertility disorders in both males and females. At the hormonal level, phthalates can modify the release of hypothalamic, pituitary, and peripheral hormones. At the intracellular level, phthalates can interfere with nuclear receptors, membrane receptors, intracellular signaling pathways, and modulate gene expression associated with reproduction. To understand and to treat the adverse effects of phthalates on human health, it is essential to expand the current knowledge concerning their mechanism of action in the organism.

show abstract

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

See 2 more Smart Citations

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Hlisníková

Petrovičová

Kolena

et al. 2020

IJERPH

163

View full text Add to dashboard Cite

show abstract

“…In recent years, there have been many studies on the toxicity of DEHP, DOP and DBP to the reproductive system, and great progresses have been made. In Taiwan, an epidemiological study shows that phthalate exposure has an effect on the level of female reproductive hormones (4). Di (2-ethylhexyl) phthalate (DEHP) causes developmental and functional impairment of reproductive organs in female mice, resulting in abnormal serum progesterone levels (5).…”

Section: Introductionmentioning

confidence: 99%

Effects of Dimethyl Phthalate (DMP) on Serum Sex Hormone Levels and Apoptosis in C57 Female Mice

Mei¹,

Rongshuang²,

Zhang³

et al. 2019

Int J Endocrinol Metab

View full text Add to dashboard Cite

Background The effects of dimethyl phthalate (DMP) on the reproductive system of mammal females are unclear because no studies have been conducted on this topic. Methods In this study, 40 C57 female mice were used as experimental subjects and evenly divided into 8 groups, which were fed with mixed DMP (0, 0.5, 1, and 2 g/kg bw/day) and corn oil. After 20 days and 40 days of gavage, the mice were weighed and their individual ovary organ coefficients measured. Results Changes were discovered on progesterone, estradiol, follicle-stimulating hormone and luteinizing hormone in mouse serum, and on the apoptosis rate of ovarian granulosa cells. Conclusions Prolonged exposure to DMP led to decreased secretion of FSH hormones and increased secretion of E2 and LH hormones. Furthermore, DMP interfered with the pituitary-ovary axis and increased the apoptosis rate of ovarian granulosa cells. Therefore, prolonged exposure to DMP is likely to have negative effects on reproduction and development.

show abstract

Association of Exposure to Phthalate Metabolites With Sex Hormones, Obesity, and Metabolic Syndrome in US Women

et al. 2022

View full text Add to dashboard Cite

ImportanceObesity and metabolic syndrome are highly prevalent among the US population and are associated with the dysregulation of sex hormones. An increase in obesity and metabolic syndrome may also be associated with exposure to phthalates. The association of exposure to phthalate metabolites with sex hormones and metabolic health has been understudied in the female population.ObjectiveTo evaluate the association between exposure to common phthalate metabolites with total testosterone (TT) levels, sex hormone–binding globulin (SHBG) levels, obesity, and metabolic syndrome among women.Design, Setting, and ParticipantsThis cross-sectional study used data collected from the National Health and Nutrition Examination Survey during 2013 to 2016. Female participants aged 15 years or older with urinary profiles containing common phthalate metabolites were included in this study. Statistical analyses were performed from March 15, 2021, to April 30, 2022.ExposuresUrinary concentrations of phthalate metabolites were classified into tertiles, and the lowest tertile was used as a reference category. The concentrations of phthalate metabolites and their composite scores based on clustering were also used in the analysis.Main Outcomes and MeasuresSerum concentrations of TT and SHBG were dichotomized into high TT levels (&gt;46 ng/dL [to convert to nanomoles per liter, multiply by 0.0347] for age &lt;50 years and &gt;32 ng/dL for age ≥50 years) and low SHBG levels (&lt;2.85 μg/mL [to convert to nanomoles per liter, multiply by 10.53]) as established for the female population. Obesity was defined as a body mass index of 30 or more (calculated as weight in kilograms divided by height in meters squared), and metabolic syndrome was defined using the National Cholesterol Education Program criteria. The serum concentrations of TT and SHBG were also included in the validation analyses. Modified Poisson models were used to estimate the adjusted relative risk (RR) with 95% CIs for the associations.ResultsAmong the 2004 women included in this study, the mean (SD) age was 46.6 (18.5) years (14.7% Hispanic participants, 62.7% non-Hispanic White participants, and 13.2% non-Hispanic Black participants; 17.4% of participants were born outside the US [weighted percentages]; 230 (11.8%) had high TT levels, 210 (10.4%) had low SHBG levels, 825 (39.8%) had obesity, and 965 (45.5%) had metabolic syndrome (weighted percentages). Of the 13 phthalate metabolites, 8 had the highest tertile level greater than 6.2 ng/mL (range, 0.5-75.2 ng/mL). High levels of exposure to mono(2-ethyl-5-carboxypentyl) phthalate (RR, 1.84 [95% CI, 1.33-2.54]), mono(2-ethyl-5-oxohexyl) phthalate (RR, 1.77 [95% CI, 1.21-2.59]), mono(2-ethyl-5-hydroxyhexyl) phthalate (RR, 1.94 [95% CI, 1.34-2.81]), and monobenzyl phthalate (RR, 1.75 [95% CI, 1.21-2.54]) were associated with low SHBG levels but not with high TT levels. High levels of exposure to some of these metabolites were also associated with obesity and metabolic syndrome. Most associations were specific to premenopausal or postmenopausal women.Conclusions and RelevanceIn this cross-sectional study, exposure to certain phthalate metabolites could be associated with low SHBG levels, obesity, and metabolic syndrome depending on menopausal status.

show abstract

Phthalate exposure and reproductive hormones and sex-hormone binding globulin before puberty – Phthalate contaminated-foodstuff episode in Taiwan

Cited by 36 publications

References 44 publications

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Effects of Dimethyl Phthalate (DMP) on Serum Sex Hormone Levels and Apoptosis in C57 Female Mice

Association of Exposure to Phthalate Metabolites With Sex Hormones, Obesity, and Metabolic Syndrome in US Women

Contact Info

Product

Resources

About