Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation

Li, Weixia; Guo, Liqiong; Fang, Junkai; Zhao, Liwei; Song, Shanjun; Fang, Tao; Li, Chenguang; Wang, Lei; Li, Penghui

doi:10.3389/fpubh.2023.1108555

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…Consistent with our findings, a study of Iranian children and adolescents revealed that MBzP was associated with elevated TG levels, and a positive correlation between MEP and TG has been observed in Chinese adults . We found associations of Cu with increased TG and TC levels, which were in line with the results from a large population-based study of 27,576 participants in Canada .…”

Section: Discussionsupporting

confidence: 92%

Exposure to a Mixture of Endocrine-Disrupting Chemicals and Metabolic Outcomes in Belgian Adolescents

Cai,

Remy,

Lenters

et al. 2023

Environ. Sci. Technol.

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Childhood exposure to endocrine-disrupting chemicals (EDCs), either alone or in mixtures, may affect metabolic outcomes, yet existing evidence remains inconclusive. In our study of 372 adolescents from the Flemish Environment and Health Study (FLEHS IV, 2017−2018), we measured 40 known and suspected EDCs and assessed metabolic outcomes, including body mass index z-score (zBMI), abdominal obesity (AO), total cholesterol (TC), and triglycerides (TG). We applied Bayesian kernel machine regression (BKMR) and Bayesian penalized horseshoe regression for variable selection and then built multivariate generalized propensity score (mvGPS) models to provide an overview of the effects of selected EDCs on metabolic outcomes. As a result, BKMR and horseshoe together identified five EDCs associated with zBMI, three with AO, three with TC, and five with TG. Through mvGPS analysis, monoiso-butyl phthalate (MIBP), polychlorinated biphenyl (PCB-170), and hexachlorobenzene (HCB) each showed an inverse association with zBMI, as did PCB-170 with AO. Copper (Cu) was associated with higher TC and TG, except in boys where it was linked to lower TG. Additionally, monoethyl phthalate (MEP) and monobenzyl phthalate (MBzP) were associated with higher TG. To conclude, our findings support the association between certain chemicals (Cu, MEP, and MBzP) and elevated lipid levels, aligning with prior studies. Further investigation is needed for sex-specific effects.

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Section: Discussionsupporting

confidence: 92%

Exposure to a Mixture of Endocrine-Disrupting Chemicals and Metabolic Outcomes in Belgian Adolescents

Cai,

Remy,

Lenters

et al. 2023

Environ. Sci. Technol.

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“…PAEs were also quantified with high concentration levels in various microenvironments such as water, soil, dust, air or food, and personal care products collected from China [7,12]. Furthermore, PAE metabolites were also detected in marine organisms [13] and found in biological or tissue samples such as urine, blood, sweat samples, or semen of infertile men [14][15][16].…”

Section: Introduction *mentioning

confidence: 99%

Distribution of Phthalate Acid Esters in Indoor and Outdoor Air Samples Collected from Hanoi Metropolitan Areas in Vietnam

Tu,

Anh,

Nhai

et al. 2023

NST

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In this study, ten phthalic acid esters (PAEs) were measured in indoor and outdoor air samples collected from Hanoi metropolitan areas. The target compounds were adsorbed onto a solid adsorbent matrix (C18) with a low-speed pump and then analyzed on a gas chromatography tandem mass spectrometry. The recoveries of surrogate standards ranged from 78.5 to 112% (RSD < 15%). The method detection limits of target compounds were in the range of 0.08-0.3 ng/m3. The total mean concentration of 10 PAEs in indoor and outdoor samples were in ranges of 1400-3710 ng/m3 and 178-487 ng/m3, respectively. Among PAEs, di-(2-ethyl)hexyl phthalate (DEHP) was found at the highest abundance and concentration. The distribution of PAEs in indoor air was higher significantly than those in outdoor air samples. Some pairs of PAEs (BzBP vs DCHP, DEHP vs DnHP, DnHP vs DnOP, and DEHP vs DnOP) had strong correlations and suggested that they are from the same source. Human exposure doses to PAEs through inhalation were estimated for two age groups (children and adults) based on the measured concentrations of PAEs in air, inhalation rates, and body weights. The estimated daily intake doses were in ranges of 29.7-750 ng/kg-bw/d and 7.29-181 ng/kg-bw/d for children and adults, respectively.

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Association between environmental phthalates exposure and gut microbiota and metabolome in dementia with Lewy bodies

Deng,

Li,

Jing

et al. 2024

Environment International

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Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation

Cited by 4 publications

References 55 publications

Exposure to a Mixture of Endocrine-Disrupting Chemicals and Metabolic Outcomes in Belgian Adolescents

Exposure to a Mixture of Endocrine-Disrupting Chemicals and Metabolic Outcomes in Belgian Adolescents

Distribution of Phthalate Acid Esters in Indoor and Outdoor Air Samples Collected from Hanoi Metropolitan Areas in Vietnam

Association between environmental phthalates exposure and gut microbiota and metabolome in dementia with Lewy bodies

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