Phthalic Acid: A Green, Biodegradable and Environmentally Benign Nature Di-Functional Brønsted Acid Catalyst for the One-Pot Synthesis of 3, 4-Dihydropyrimidin-2- (1h)-One Derivatives and Substituted Dihydro-2-Oxypyrroles

Abstract

Phthalic acid as a green, biodegradable economical and environmentally benign nature catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives via β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions and one-pot four-component domino condensation of substituted dihydro-2-oxypyrrole by reaction of dialkyl acetylenedicarboxylate, formaldehyde and amines (aromatic and aliphatic) under ambient temperature with short reaction times and excellent yields is reported. The most benefits this procedure are such as green, biodegradable, inexpensive and non-toxic catalyst, eco-friendly, high catalytic activity, efficient, easily separation with no column chromatographic separation, simple operational procedures, one-pot, excellent yields, environmentally benign nature.

Niobium Oxides as Heterogeneous Catalysts for Biginelli Multicomponent Reaction

“…mp (°C): 251−253 (lit. 247−249) 44. IR (KBr, cm −1 ): 3364, 3225, 3099, 2940, 2841, 1704, 1649, 1450, 1437, 1377, 1324, 1225, 1185, 1090, 1030, 954, 844 and 787.…”

Al2(SO4)3·18H2O as an Eco-Safe Catalyst Promoting Synthesis of Polysubstituted Dihydropyrrol-2-ones

“…Recently, the study of the synthesis of nitrogencontaining heterocyclic compounds, such as pyrrole rings, has attracted considerable interest among organic chemists because of their special biological and pharmaceutical activities [1][2][3][4][5][6][7][8][9]. In the past decades, considerable attention has been paid to the design of efficient and environmental friendly synthetic route by using of multi-component reactions (MCRs) [10][11][12][13][14][15][16][17] due to a wide range of points, such as atom-economy, simple work-up, mildness and environmental friendliness, one pot, and low cost. Due to the importance of polysubstituted dihydropyrrol-2-ones, various methodologies for the preparation of these 1 School of Engineering, Apadana Institute of Higher Education, Shiraz, Iran * Mohamadpour.f.7@gmail.com Ó Mohamadpour F., 2020 compounds have been developed, such as Cu(OAc) 2 •H 2 O [18], InCl 3 [19], I 2 [20], AcOH [21], [n-Bu 4 N][HSO 4 ] [22], Al(H 2 PO 4 ) 3 [23], oxalic acid [24], ZrCl 4 [25], [Hpyro][HSO 4 ] [26], and p-TsOH•H 2 O [27] can be used as catalysts for this transformation.…”