Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae

Yang, Xiao‐Long; Zhang, Su; Hu, Qiongbo; Luo, Du‐Qiang; Zhang, Yan

doi:10.1038/ja.2011.82

Cited by 39 publications

(18 citation statements)

References 18 publications

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“…Until 2005, approximately 180 naturally occurring phthalides had been isolated, most of them from the Apiaceae family . Compounds containing γ –lactone, particularly naturally occurring phthalides and their synthetic analogues, exhibit not only a variety of pharmacological but also phytotoxic, fungicidal and insecticidal activities . Some of these molecules are presented in Fig.…”

Section: Introductionmentioning

confidence: 99%

Toxicity to Diaphania hyalinata, selectivity to non‐target species and phytotoxicity of furanones and phthalide analogues

Resende

Alvarenga

Araújo

et al. 2016

Pest Management Science

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Section: Introductionmentioning

confidence: 99%

Toxicity to Diaphania hyalinata, selectivity to non‐target species and phytotoxicity of furanones and phthalide analogues

Resende

Alvarenga

Araújo

et al. 2016

Pest Management Science

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“…Previous investigations reported that the destruction of the bacterial cell might be the possible antifungal activity of compounds isolated from the Pestalotiopsis sp. [23,24]. In this study, we found that the endophytic fungus Pestalotiopsis sp.…”

Section: Resultsmentioning

confidence: 84%

Cytotoxic and Antifungal Constituents Isolated from the Metabolites of Endophytic Fungus DO14 from Dendrobium officinale

Jia

Ling

et al. 2015

Molecules

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Two novel cytotoxic and antifungal constituents, (4S,6S)-6-[(1S,2R)-1, 2-dihydroxybutyl]-4-hydroxy-4-methoxytetrahydro-2H-pyran-2-one (1), (6S,2E)-6-hydroxy-3-methoxy-5-oxodec-2-enoic acid (2), together with three known compounds, LL-P880γ (3), LL-P880α (4), and Ergosta-5,7,22-trien-3b-ol (5) were isolated from the metabolites of endophytic fungi from Dendrobium officinale. The chemical structures were determined based on spectroscopic methods. All the isolated compounds 1-5 were evaluated by cytotoxicity and antifungal effects. Our present results indicated that compounds 1-4 showed notable anti-fungal activities (minimal inhibitory concentration (MIC) ď 50 µg/mL) for all the tested pathogens including Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, Aspergillus fumigatus. In addition, compounds 1-4 possessed notable cytotoxcities against human cancer cell lines of HL-60 cells with the IC 50 values of below 100 µM. Besides, compounds 1, 2, 4 and 5 showed strong cytotoxities on the LOVO cell line with the IC 50 values were lower than 100 µM. In conclusion, our study suggested that endophytic fungi of D. officinale are great potential resources to discover novel agents for preventing or treating pathogens and tumors.

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“…MP was provided by our research group at Hebei University (purity >99%, HPLC analysis) (7) and dissolved in DMSO.…”

Section: Methodsmentioning

confidence: 99%

“…MP was first isolated from Alternaria porri and reported to have antifungal activity and cytotoxic activity in cancer cell lines 9 (5- 7). Although cytotoxic activity of MP was reported, little was known about the molecular mechanism of this effect of MP.…”

Section: Introductionmentioning

confidence: 99%

A phthalide derivative isolated from endophytic fungiPestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells

Chen

Yang²

2013

Braz J Med Biol Res

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MP [4-(3′,3′-dimethylallyloxy)-5-methyl-6-methoxyphthalide] was obtained from liquid culture of Pestalotiopsis photiniae isolated from the Chinese Podocarpaceae plant Podocarpus macrophyllus. MP significantly inhibited the proliferation of HeLa tumor cell lines. After treatment with MP, characteristic apoptotic features such as DNA fragmentation and chromatin condensation were observed in DAPI-stained HeLa cells. Flow cytometry showed that MP induced G1 cell cycle arrest and apoptosis in a dose-dependent manner. Western blotting and real-time reverse transcription-polymerase chain reaction were used to investigate protein and mRNA expression. MP caused significant cell cycle arrest by upregulating the cyclin-dependent kinase inhibitor p27KIP1 protein and p21CIP1 mRNA levels in HeLa cells. The expression of p73 protein was increased after treatment with various MP concentrations. mRNA expression of the cell cycle-related genes, p21CIP1, p16INK4a and Gadd45α, was significantly upregulated and mRNA levels demonstrated significantly increased translation of p73, JunB, FKHR, and Bim. The results indicate that MP may be a potential treatment for cervical cancer.

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Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae

Cited by 39 publications

References 18 publications

Toxicity to Diaphania hyalinata, selectivity to non‐target species and phytotoxicity of furanones and phthalide analogues

Toxicity to Diaphania hyalinata, selectivity to non‐target species and phytotoxicity of furanones and phthalide analogues

Cytotoxic and Antifungal Constituents Isolated from the Metabolites of Endophytic Fungus DO14 from Dendrobium officinale

A phthalide derivative isolated from endophytic fungiPestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells

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