Phthalide-derived novel fluoroionophores incorporating picolylamino receptors: synthesis and response to metal cations

Abstract

Phthalide derivatives incorporating mono- and di-picolylamino functionalities at the 6-position have been prepared as novel fluoroionophores and their fluorescence responses to metal cations have been investigated. These phthalides not only exhibited efficient fluorescence in an aqueous medium but also displayed fluorescence on-off response upon addition of transition-metal cations, namely Cu(2+). The 6-aminophthalide fluorophore served as the core of the fluorescent probes although it has rarely been applied to a chemosensor. To the best of our knowledge, these modified phthalides are the first 6-aminophthalide-derived fluorometric probes for metal cations, namely Cu(2+).

Solvent-induced multicolour fluorescence of amino-substituted 2,3-naphthalimides studied by fluorescence and transient absorption measurements

“…29 Recently, 6-aminophthalide derivatives have also been reported as solvent-responding fluorophores. 30,31 Imperiali et al have reported the efficient synthesis and photophysical behaviour of the 6-dimethylamino-derivatives of 2,3-naphthalimide . They demonstrated that 6-DMNs showed marked positive solvatofluorochromism and successfully applied their photophysical features to monitoring protein binding interactions.…”