Phthalocyanine photosensitizers as contrast agents for in vivo photoacoustic tumor imaging

Attia, Amalina Binte Ebrahim; Balasundaram, Ghayathri; Driessen, Wouter H. P.; Ntziachristos, Vasilis; Olivo, Malini

doi:10.1364/boe.6.000591

Cited by 45 publications

(31 citation statements)

References 30 publications

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“…According to the employed configurations of optical excitation and acoustic detection, PAT has two major implementations: photoacoustic microscopy (PAM) and photoacoustic computed tomography (PACT) . PAT is sensitive to the optical absorption contrast in the tissue, and can map the total hemoglobin concentration , oxygen saturation , tumor angiogenesis and blood flow . Therefore, PAT has been widely used for vascular‐related physiological and pathological studies on small animal models .…”

Section: Introductionmentioning

confidence: 99%

Impacts of the murine skull on high‐frequency transcranial photoacoustic brain imaging

Liang

Liu

Zhan

et al. 2019

Journal of Biophotonics

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Non‐invasive photoacoustic tomography (PAT) of mouse brains with intact skulls has been a challenge due to the skull's strong acoustic attenuation, aberration, and reverberation, especially in the high‐frequency range (>15 MHz). In this paper, we systematically investigated the impacts of the murine skull on the photoacoustic wave propagation and on the PAT image reconstruction. We studied the photoacoustic acoustic wave aberration due to the acoustic impedance mismatch at the skull boundaries and the mode conversion between the longitudinal wave and shear wave. The wave's reverberation within the skull was investigated for both longitudinal and shear modes. In the inverse process, we reconstructed the transcranial photoacoustic computed tomography (PACT) and photoacoustic microscopy (PAM) images of a point target enclosed by the mouse skull, showing the skull's different impacts on both modalities. Finally, we experimentally validated the simulations by imaging an in vitro mouse skull phantom using representative transcranial PAM and PACT systems. The experimental results agreed well with the simulations and confirmed the accuracy of our forward and inverse models. We expect that our results will provide better understanding of the impacts of the murine skull on transcranial photoacoustic brain imaging and pave the ways for future technical improvements.

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Section: Introductionmentioning

confidence: 99%

Impacts of the murine skull on high‐frequency transcranial photoacoustic brain imaging

Liang

Liu

Zhan

et al. 2019

Journal of Biophotonics

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“…One study compared different hydrophilic Pcs: phthalocyanine tetrasulfonic acid (PcS4), Zn (II) phthalocyanine tetrasulfonic acid (ZnPcS4), and Al (III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) as contrast agents for photoacoustic images, 39 showing that optical contrast in tumors was greatly enhanced by PcS4 and ZnPcS4 ( Figure 5). Other hydrophilic Pc or Nc conjugates were also designed including saccharide-based conjugates.…”

Section: Hydrophilic Modifications Of Pcs and Ncs For Bioimagingmentioning

confidence: 99%

Recent applications of phthalocyanines and naphthalocyanines for imaging and therapy

Zhang

Lovell

2016

WIREs Nanomed Nanobiotechnol

143

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With high extinction coefficients and long absorption wavelengths in the near infrared region, phthalocyanines (Pcs) and naphthalocyanines (Ncs) are well-suited for optical imaging and phototherapies in biological tissues. Pcs and Ncs have been used in a range of theranostic applications. Peripheral and axial substituents can be introduced to Pcs and Ncs for chemical modification. Seamless metal chelation of Pcs or Ncs can expand their possibilities as medical therapeutic and imaging agents. Nanoparticulate approaches enable unique ways to deliver Pcs and Ncs to target tissues and improve their solubility, biocompatibility, biodistribution and stability. Herein, we highlight some recent Pc or Nc nanoscale systems for theranostic applications.

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“…Using optical imaging for the indication of drug distribution needs to be carefully discerned, especially when imaging agents are physically integrated with the drug. Adopting new imaging modalities, such as fluorescence lifetime [66] and photoacoustic techniques [67,68], may further the application of hybrid nanocrystals for concurrent anticancer therapy and bioimaging.…”

Section: Hybrid Nanocrystalsmentioning

confidence: 99%

Developing Nanocrystals for Cancer Treatment

Lü

Cao

Gemeinhart

et al. 2015

Nanomedicine (Lond.)

113

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Nanocrystals are carrier-free solid drug particles that are sized in the nanometer range and have crystalline characteristics. Due to high drug loading (as high as 100%) - free of organic solvents or solubilizing chemicals - nanocrystals have become attractive in the field of drug delivery for cancer treatment. Top-down and bottom-up approaches have been developed for preparing anticancer nanocrystals. In this review, preparation methods and in vivo performance of anticancer nanocrystals are discussed first, followed by an introduction of hybrid nanocrystals in cancer theranostics.

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Phthalocyanine photosensitizers as contrast agents for in vivo photoacoustic tumor imaging

Cited by 45 publications

References 30 publications

Impacts of the murine skull on high‐frequency transcranial photoacoustic brain imaging

Impacts of the murine skull on high‐frequency transcranial photoacoustic brain imaging

Recent applications of phthalocyanines and naphthalocyanines for imaging and therapy

Developing Nanocrystals for Cancer Treatment

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