Phthalocyanines bearing silazane group for colorectal cancer

Özdemir, Mücahit; Artuç, Gamze Özgül; Güler, Eray Metin; Yalçın, Bahattin; Salan, Ümit; Bozalı, Kübra; Görgülü, Ahmet Orhan; Bulut, Mustafa

doi:10.1016/j.dyepig.2021.109832

Cited by 12 publications

(2 citation statements)

References 58 publications

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“…DLD-1 The non-peripherally substituted zinc phthalocyanine displayed the highest apoptotic, cytotoxic, and genotoxic effects on the LoVo cell lines. 69 Nkune et al studied the photosensitizing properties of zinc phthalocyanine tetrasulfonic acid and its gold nanoconjugates using colorectal cancer (CRC) cells. All the compounds especially the nanoconjugates exhibited high activity.…”

Section: Mtt Assaymentioning

confidence: 99%

The effect of phthalocyanine's periphery on the biological activities of carbazole-containing metal phthalocyanines

et al. 2023

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Section: Mtt Assaymentioning

confidence: 99%

The effect of phthalocyanine's periphery on the biological activities of carbazole-containing metal phthalocyanines

et al. 2023

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“…Pcs are condensation product of four iminoisoindoline units and consist of a planar macro ring with an 18-π electron system. [8] Pcs are used in industry, biomedical, and therapeutic areas because of their physical and chemical properties. [9][10][11][12][13] In addition, Pcs can be coordinated with almost all metals such as zinc (II), silicon (IV), gallium (III), iron (II), cobalt (II), copper (II), etc.…”

Section: Introductionmentioning

confidence: 99%

DNA interaction, cytotoxic and phototoxic properties of new water‐soluble zinc (II) phthalocyanines

Bıyıklıoğlu

Baş

Altun

et al. 2022

Applied Organom Chemis

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In this paper, we have synthesized water‐soluble peripherally tetra and octa‐({6‐[3‐(dimethylamino)phenoxy]hexyl}oxy) groups substituted zinc (II) phthalocyanines (DM‐C6‐ZnQ and o‐DM‐C6‐ZnQ). Also, we have investigated ct‐DNA binding, supercoiled plasmid DNA cleavage properties of DM‐C6‐ZnQ and o‐DM‐C6‐ZnQ by using spectrophotometric and electrophoretic methods. On the other hand, cytotoxic and phototoxic effects of DM‐C6‐ZnQ and o‐DM‐C6‐ZnQ were examined using (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay on human lung adenocarcinoma (A549) cell lines. In UV–Vis absorption studies, hypochromism was observed about 18% for DM‐C6‐ZnQ and 57% for o‐DM‐C6‐ZnQ on addition of increasing concentrations of ct‐DNA. The intrinsic binding constant (Kb) values of DM‐C6‐ZnQ and o‐DM‐C6‐ZnQ were 3.82 (±0.14) × 104 M−1 and 2.34 (±0.05) × 105 M−1, respectively. The supercoiled plasmid DNA cleavage studies showed that DM‐C6‐ZnQ and o‐DM‐C6‐ZnQ had no DNA damage actions in the dark. On the other hand, they caused DNA damage depending on the light dose. In the MTT assay, the compounds had low cytotoxic properties on A549 cell lines, but they showed significant phototoxic actions. These results reveal that the compounds interact with DNA and have phototoxic properties; it has been determined that they have the potential to be photosensitizing agents for photodynamic therapy.

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Synthesis, characterization, in vitro cytotoxicity of novel metallo phthalocyanines with four methylpropiophenonyl clusters and their effects on Caenorhabditis elegans thermotolerance

Şenoğlu

Güleç²,

Dokgöz³

et al. 2022

Chem. Pap.

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Phthalocyanines bearing silazane group for colorectal cancer

Cited by 12 publications

References 58 publications

The effect of phthalocyanine's periphery on the biological activities of carbazole-containing metal phthalocyanines

The effect of phthalocyanine's periphery on the biological activities of carbazole-containing metal phthalocyanines

DNA interaction, cytotoxic and phototoxic properties of new water‐soluble zinc (II) phthalocyanines

Synthesis, characterization, in vitro cytotoxicity of novel metallo phthalocyanines with four methylpropiophenonyl clusters and their effects on Caenorhabditis elegans thermotolerance

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