Phthiocol Chelates of Bis(Cyclopentadienyl)titanium(IV)

Metabolic mimics: Thiol responsive drug release

“…This was synthesised from 2-hydroxy-1,4-naphthoquinone, hydrogen peroxide and sulphuric acid using the procedure recorded by Kaushik and co-workers [12].…”

Molecular anchors—mimicking metabolic processes in thiol analysis

“…The response to histidine was also assessed as the imidazole substituent possesses amine functionality that has a pK a of 5 and hence nucleophile potential. [13][14][15] There was essentially no response to the amino acid (1 mM). In this case the lack of response can be attributed to the resonance within the imidazole ring which under the conditions of the experiment did not present an effective challenge to the film.…”

Rapid assessment of the latent hazard posed by dissolved mercaptans within aqueous effluent

“…A range of amines were tested covering both alkyl and aryl moieties (various amino acids, imidazoles and aniline derivatives in 100-fold excess, millimolar concentration) but were not found to illicit any appreciable reaction under the conditions and the initial timescale of the investigations [20]. Prolonged standing however is obviously problematic allowing the possibility of gradual reaction [21,22]. The degree to which this could compromise the detection sensitivity of the target thiol will obviously depend on the nature of the interfering group and their associated retention characteristics.…”