Phthisis Bulbi: Clinical and Pathologic Findings in Retinoblastoma

Taha, Hala; Amer, Hoda Zeinab M.; El-Zomor, Hosam; Alieldin, Adel; Nour, Radwa; Konsowa, Rokayya; Zekri, Wael; Nadi, Enas El; Alfaar, Ahmad Samir

doi:10.3109/15513815.2015.1014951

Cited by 11 publications

(8 citation statements)

References 14 publications

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“…measles, vitamin A deficiency, and ophthalmia neonatorum) [15–18]. Many of these causes often lead to subsequent corneal scarring or phthisis bulbi [8, 19, 20]. In West Africa, nutritional deficiencies and ocular infections continue to be significant risk factors for childhood blindness, but much progress has been made with public health campaigns in measles vaccinations and vitamin A supplementation [21, 22].…”

Section: Discussionmentioning

confidence: 99%

Causes of childhood blindness in Ghana: results from a blind school survey in Upper West Region, Ghana, and review of the literature

2017

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Section: Discussionmentioning

confidence: 99%

Causes of childhood blindness in Ghana: results from a blind school survey in Upper West Region, Ghana, and review of the literature

2017

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“…Phthisis bulbi represents an ocular end-stage disease characterized by atrophy, shrinkage, and disorganization of the eye and intraocular contents. [ 8 ]…”

Section: Introductionmentioning

confidence: 99%

Treatment of Bacillus cereus endophthalmitis with endoscopy-assisted vitrectomy

et al. 2017

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To evaluate the use of endoscopy-assisted vitrectomy in patients with sight-threatening Bacillus cereus endophthalmitis.A retrospective analysis was conducted in 15 eyes with Bacillus cereus endophthalmitis. Patients were divided into 2 groups: endoscopy-assisted vitrectomy (5 eyes) and conventional vitrectomy (10 eyes). The following clinical data were recorded and analyzed: sex, age, latent period, symptom duration, follow-up time, visual acuity pre- and postsurgery, recurrence of endophthalmitis, incidence of phithisis bulbi, and incidence of enucleation.In the conventional vitrectomy group, postoperative visual acuity ranged from no light perception in 5 patients (50%), light perception in 3 patients (30%), 20/1000 in 1 patient (10%), and 20/50 in 1 patient (10%). In the endoscopy-assisted vitrectomy group, postoperative visual acuity ranged from no light perception in 2 patients (40%), light perception in 1 patient (20%), and hand movements in 2 patients (40%). There was no statistically significant difference between the 2 groups in terms of the final postoperative visual acuity (F = 0.006, P = .937). There is no difference between the 2 groups in terms of the incidence of enucleation. The median symptom duration was 4 hours (range: 2–6 hours) in the conventional group and 9 hours (range: 7–11 hours) in the endoscopy-assisted vitrectomy group. The difference in the symptom duration between the 2 groups was statistically significant (P = .002).There is no statistical significant difference between the 2 groups in terms of visual acuity and incidence of enucleation. Therefore, endoscopy-assisted vitrectomy can be considered as an alternative treatment for treatment of B cereus endophthalmitis particularly for cases when symptom duration was more than 6 hours.

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“…Phthisis bulbi could be induced not only by ocular mechanical injury but also radiation, infective agents, diffuse illness or could arise in association with neoplastic tumors such a retinoblastoma. 17 Massive retinal gliosis is defi ned as nonneoplastic retinal glial lesion. 5 However, not all cases of retinal gliosis are massive so the better name would be reactive retinal gliosis instead of massive retinal gliosis.…”

Section: Clinical and Pathological Presentationmentioning

confidence: 99%

Review on Retinal Gliosis Illustrated with a Series of Massive Glioses and Focal Nodular Gliosis Cases in Regard to Potential Pitfalls of Ocular Reactive Tumor-like Lesions of this Type

Wincewicz¹,

Urbaniak-Wasik²,

Urbaniak³

et al. 2018

Folia Medica

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This paper presents a review on retinal gliosis illustrated by series of three cases of patients (a 39-year-old man and a 35-year-old woman with massive retinal gliosis (MRG) and a 51-year-old man with truly focal nodular gliosis of retina) with intraocular tumor-like masses and loss of vision, who recently suffered from painful inflammation of eyeball and who classically had a history of remote ocular trauma, onset of blindness early in lifetime or gradual but progressive loss of sight. The diagnosis of this pathological entity is given for the lesions that are composed of GFAP strongly positive, elongated, fusiform cells consistent with fibrillary astrocytes. As illustrated in cases from our pathological practice, PAS gave positive patchy disseminated reaction in form of cellular densely purplish granules in minority of cells representing glycogen storing. This feature could be consistent with PAS-positive Müller cells that also constitute retinal gliosis as one of cellular components of normal retina that is induced to reactive proliferation. Thus, the paper presents histological background and differential diagnosis of the entity.

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Phthisis Bulbi: Clinical and Pathologic Findings in Retinoblastoma

Abstract: We conclude that retinoblastoma must be considered in the differential diagnosis of phthisis bulbi in the pediatric patients and active tumor was present in half of the patients.

Cited by 11 publications

References 14 publications

Causes of childhood blindness in Ghana: results from a blind school survey in Upper West Region, Ghana, and review of the literature

Causes of childhood blindness in Ghana: results from a blind school survey in Upper West Region, Ghana, and review of the literature

Treatment of Bacillus cereus endophthalmitis with endoscopy-assisted vitrectomy

Review on Retinal Gliosis Illustrated with a Series of Massive Glioses and Focal Nodular Gliosis Cases in Regard to Potential Pitfalls of Ocular Reactive Tumor-like Lesions of this Type

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