Phychemistry, Phytochemical, Pharmacological and Molecular Study of Zingiber Officinale Roscoe: A Review

Abstract

The rhizomes of Zingiber officinale Roscoe (Zingiberaceae), commonly known as ginger, is one of the most widely used spice and condiment. It is also an integral part of many traditional medicines and has been extensively used in Chinese, Ayurvedic, Tibb-Unani, Srilankan, Arabic, and African traditional medicines, since antiquity, for many unrelated human ailments including common colds, fever, sore throats, vomiting, motion sickness, gastrointestinal complications, indigestion, constipation, gastritis, epigastric discomfort, gastric ulcerations, indigestion, nausea vomiting etc, and scientific studies have validated the ethnomedicinal uses. The present review tries to summarize and document the phytochemistry, phytochemical, pharmacological and molecular work done on ginger. The data was compiled to provide consolidated information covering different aspects of the plant, to provide a basis on which to plan future studies and to promote sustainable use of Z. officinale.

Using Brewer’s Yeast and Ginger in the Management of Constipation-Predominant Irritable Bowel Syndrome: A Randomized Double-Blind Placebo-Controlled Trial

“…Ginger is a safe, widely available, and low-cost herb that has been proved to have many useful antiemetics, anti-inflammatory, sedative, and analgesic properties, in addition to its beneficial effects on blood circulation [22]. Concerning the gastrointestinal diseases, ginger was found to be valuable in alleviating many GIT symptoms such as pain, bloating, constipation, nausea and vomiting, and improving gut motility [26,27,29].…”

“…On the other hand, ginger is an important traditional herb that has been used by ancient Chinese and Indian people [21]. Ginger was used primarily for it antiemetic, anti-inflammatory, and analgesic properties that have been proven from many previous studies [22]. Furthermore, it was found to improve blood circulation, lower blood cholesterol, and lower blood glucose and treat migraine headaches [23][24][25].…”

Correlation of Antioxidant and Antiproliferative Activity of Amla and Ginger

“…Accumulating evidence suggests that many dietary factors like antioxidants (polyphenols) are used alone or in combination with traditional/conventional chemotherapy to prevent or treat cancer [26][27][28][29][30][31][32][33][34][35]. Crude and processed plant extracts are studied extensively to evaluate its role in treatment as chemopreventive drug or to use in combination that can synergistically improve the outcome of current chemotherapy and lower the toxicity [36][37][38].…”

“…Our study focused on evaluating the direct effect of aqueous extract of ginger and amla, in its natural dietary form. Ginger is traditionally used in tea and as "trikatu" as a therapeutic decoction to improve the immunity, metal detoxification, digestion, and fight against the cold inflammation in Indian continent [56][57][58][59][60]. High doses of antioxidants have been shown to inhibit the growth of different rodent and human cancer cells in vivo and in vitro [61][62][63][64][65].…”

Restorative Effects of Zingiber Officinale on Arsenic-Induced Genotoxic Effects in Chromosomal Structure of Mice

“…It was dissolved in double distilled water and administered orally to mice. Z. officinale (Ginger) was obtained from local market, and aqueous extract was prepared by the method of Ashraf et al [27] and was also administered orally to mice.…”