Phycocyanin alleviates ICV-STZ induced cognitive and molecular deficits via PI3-Kinase dependent pathway

Agrawal, Madhunika; Perumal, Yamini; Bansal, Seema; Arora, Sangeeta; Chopra, Kanwaljit

doi:10.1016/j.fct.2020.111684

Cited by 39 publications

(23 citation statements)

References 42 publications

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“…Also, attenuates neuro-inflammation and dysfunctional insulin signaling. Therapeutic agent in managing Alzheimer's Disease [110] Spirulina sp. / Inhibits A53Tα-synuclein and Aβ40/42 fibril formation, but do not inhibit the reduction-induced amorphous aggregation of ADH and heat-induced aggregation of catalase.…”

Section: Biotechnological Perspectives Of Pbpsmentioning

confidence: 99%

“…Parkinson’s and Alzheimer’s disease ( Table 8 ), which are mediated by the misfolding and aggregation of proteins such as α-synuclein (αS) and amyloid-β (Aβ), respectively [107] , where inhibited by C-PC [108] , but was ineffective in inhibiting the reduction-induced amorphous aggregation of ADH and heat-induced aggregation of catalase [109] . In addition, intracerebroventricular cognitive decline in the Alzheimer's disease [110] . PE also was proposed as a putative therapeutic drug for the Alzheimer’s disease due to the inhibition of the beta -site amyloid precursor protein cleaving enzyme-1 (BACE1) [111] .…”

Section: Biotechnological Perspectives Of Pbpsmentioning

confidence: 99%

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Phycobiliproteins: Structural aspects, functional characteristics, and biotechnological perspectives

Dagnino‐Leone

Figueroa

Castañeda

et al. 2022

Computational and Structural Biotechnology Journal

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Section: Biotechnological Perspectives Of Pbpsmentioning

confidence: 99%

Section: Biotechnological Perspectives Of Pbpsmentioning

confidence: 99%

Phycobiliproteins: Structural aspects, functional characteristics, and biotechnological perspectives

Dagnino‐Leone

Figueroa

Castañeda

et al. 2022

Computational and Structural Biotechnology Journal

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“…IRS-1 binds primarily to phosphatidylinositol 3-kinase (PI3K), and phosphorylated PI3K leads to activation of 3-phosphoinositide-dependent protein kinase-1 (PDK1), which in turn phosphorylates serine/threonine protein kinase B (AKT). Phycocyanin has been shown to increase INS-IR binding affinity, IRS-1 activation of PI3K and AKT, resulting in initiation of the IRS/PI3K/AKT pathway, and slightly reduced expression of the phosphatase and tensin homolog (PTEN) gene, an inhibitor of the PI3K/AKT pathway [ 94 ].…”

Section: Beneficial Effects Of Spirulina In Neurodegenerative Diseasesmentioning

confidence: 99%

Beneficial Effects of Spirulina Consumption on Brain Health

et al. 2022

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Spirulina is a microscopic, filamentous cyanobacterium that grows in alkaline water bodies. It is extensively utilized as a nutraceutical food supplement all over the world due to its high levels of functional compounds, such as phycocyanins, phenols and polysaccharides, with anti-inflammatory, antioxidant, immunomodulating properties both in vivo and in vitro. Several scientific publications have suggested its positive effects in various pathologies such as cardiovascular diseases, hypercholesterolemia, hyperglycemia, obesity, hypertension, tumors and inflammatory diseases. Lately, different studies have demonstrated the neuroprotective role of Spirulina on the development of the neural system, senility and a number of pathological conditions, including neurological and neurodegenerative diseases. This review focuses on the role of Spirulina in the brain, highlighting how it exerts its beneficial anti-inflammatory and antioxidant effects, acting on glial cell activation, and in the prevention and/or progression of neurodegenerative diseases, in particular Parkinson’s disease, Alzheimer’s disease and Multiple Sclerosis; due to these properties, Spirulina could be considered a potential natural drug.

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“…Similarly, NF-κB levels were also increased in the disease group, which was reversed by treatment with the mTOR inhibitor. Studies have reported that ICV-STZ administration results decrease in antiapoptotic factor Bcl2 and increase of apoptotic factor Bax [46,47]. During this, Bax/Bcl2 ratio is increased.…”

Section: Discussionmentioning

confidence: 98%

Everolimus: A potential therapeutic agent targeting PI3K/Akt pathway in brain insulin system dysfunction and associated neurobehavioral deficits

Bansal

Agrawal

Mahendiratta

et al. 2021

Fundamemntal Clinical Pharma

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Background: It is well accepted that PI3k/Akt signaling pathway is a potential therapeutic window which regulates metabolism and energy homeostasis within the brain, and is an important mediator of normal neuronal physiological functions. Dysregulation of this pathway results in impaired insulin signaling, learning and memory and neuronal survival.Objectives: Elucidating the role of everolimus in intracerebroventricular (ICV) streptozotocin induced Insulin/IGF-1 dependent PI3K/Akt/mTOR pathway dysregulation and associated neurobehavioral deficits.Methods: Rats were administered with streptozotocin (3 mg/kg) intracerebroventricular, followed by administration of everolimus (1 mg/kg) orally for 21 days. After that, Morris water maze and passive avoidance tests were performed for assessment of memory. Animals were sacrificed to evaluate brain insulin pathway dysfunction, neurotrophic, apoptotic, inflammatory, and biochemical markers in rat brain. To elucidate the mechanism of action of everolimus, PI3K inhibitor, wortmannin was administered in the presence of everolimus in one group.Results: Streptozotocin administration resulted in a significant decrease of brain insulin, insulin growth factor-1 levels, and alterations in behavioral, neurotrophic (BDNF), inflammatory (TNF-α), apoptotic (NF-κB, Bcl2 and Bax) and biochemical (AChE and ChAT assay) parameters in comparison to sham group rats. Everolimus significantly mitigated the deleterious behavioral, biochemical, and molecular changes in rats having central insulin dysfunction.However, the protective effect of everolimus was completely abolished when it was administered in the presence of wortmannin. Conclusion:Findings from the study reveal that mTOR inhibitors can be an important treatment strategy for neurobehavioral deficits occurring due to central insulin pathway dysfunction. Protective effect of drugs is via modulation of PI3K/Akt pathway.

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Phycocyanin alleviates ICV-STZ induced cognitive and molecular deficits via PI3-Kinase dependent pathway

Cited by 39 publications

References 42 publications

Phycobiliproteins: Structural aspects, functional characteristics, and biotechnological perspectives

Phycobiliproteins: Structural aspects, functional characteristics, and biotechnological perspectives

Beneficial Effects of Spirulina Consumption on Brain Health

Everolimus: A potential therapeutic agent targeting PI3K/Akt pathway in brain insulin system dysfunction and associated neurobehavioral deficits

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