Phycocyanin ameliorates mouse colitis<i>via</i>phycocyanobilin-dependent antioxidant and anti-inflammatory protection of the intestinal epithelial barrier

Guo, Wei; Zeng, Mingyong; Zhu, Shumin; Li, Shiyang; Qian, Yilin; Wu, Haohao

doi:10.1039/d1fo02970c

Cited by 35 publications

(18 citation statements)

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“…The injury of epithelial cells directly contributes to the disruption of the enteric epithelial barrier and systemic inflammatory complications ( Guo et al, 2022 ). Figure 2A shows the lack of significant cytotoxicity toward Caco-2 cells upon incubation with CFF of the tested LAB strains according to the data of an MTT assay ( P > 0.05).…”

Section: Resultsmentioning

confidence: 99%

Amelioration of dextran sulfate sodium-induced colitis by autoinducer-2-deficient Lactiplantibacillus plantarum is mediated by anti-inflammatory effects and alleviation of dysbiosis of the gut microbiota

Qian

Zeng

et al. 2022

Front. Microbiol.

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Lactic acid bacteria (LAB) attenuate dextran sulfate sodium (DSS)-induced colitis in mice by restoring gut flora homeostasis and modulating the immune response. Because synchronous behavior can be controlled by autoinducer-2 (AI-2)/LuxS-mediated quorum sensing, the Caco-2 cell model and DSS-induced model in C57BL/6 mice were used to explore the unknown effects of these communications involving AI-2 among various intestinal symbiotic species. The results of the cell viability and lactate dehydrogenase leakage assays indicated that the tested strains (the wild-type strains and AI-2-deficient mutants) were characterized by equal cytoprotection from hydrogen peroxide-induced injury independently of AI-2. The results of the assays of multiple indicators and proinflammatory cytokines characteristic for the symptoms of colitis in mice showed that oral administration of AI-2-deficient mutants for 7 days was more effective in ameliorating inflammation than the treatment with the wild-type strains. The treatment with AI-2-deficient mutants enriched potential probiotics (e.g., Lactobacillaceae) and controlled the proliferation of potentially harmful bacteria (e.g., Helicobacteraceae) to achieve the transformation of intestinal flora. These mutants regulated short-chain fatty acids and the intestinal epithelial barrier, thereby promoting the maintenance of relatively favorable intestinal homeostasis. These results demonstrated that the AI-2-deficient mutants provided a more pronounced ameliorative effect on colitis in a mouse model, suggesting that the background of the LAB effect is associated with the alterations in colonic flora induced by AI-2.

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Section: Resultsmentioning

confidence: 99%

Amelioration of dextran sulfate sodium-induced colitis by autoinducer-2-deficient Lactiplantibacillus plantarum is mediated by anti-inflammatory effects and alleviation of dysbiosis of the gut microbiota

Qian

Zeng

et al. 2022

Front. Microbiol.

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“…Phycocyanin has been found to possess a variety of physiological activities. It was found that phycocyanin could improve colitis in mice by protecting the intestinal epithelial cell barrier and exerting anti-inflammatory and antioxidant effects [ 289 ]. Moreover, recent studies have found that certain protein peptides from animal sources also have the same function of improving colitis; for example, bee venom peptides [ 290 ] and yellowtail protein hydrolysates [ 291 ].…”

Section: Nps With Ibd Therapeutic Activitymentioning

confidence: 99%

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

2023

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Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory disease of the intestine that can be classified as ulcerative colitis (UC) and Crohn’s disease (CD). Currently, the incidence of IBD is still increasing in developing countries. However, current treatments for IBD have limitations and do not fully meet the needs of patients. There is a growing demand for new, safe, and highly effective alternative drugs for IBD patients. Natural products (NPs) are used in drug development and disease treatment because of their broad biological activity, low toxicity, and low side effects. Numerous studies have shown that some NPs have strong therapeutic effects on IBD. In this paper, we first reviewed the pathogenesis of IBD as well as current therapeutic approaches and drugs. Further, we summarized the therapeutic effects of 170 different sources of NPs on IBD and generalized their modes of action and therapeutic effects. Finally, we analyzed the potential mechanisms of NPs for the treatment of IBD. The aim of our review is to provide a systematic and credible summary, thus supporting the research on NPs for the treatment of IBD and providing a theoretical basis for the development and application of NPs in drugs and functional foods.

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“…In a study evaluating the therapeutic effects and mechanisms of action of phycocyanin and phycocyanobilin in a murine colitis model, it was found that phycocyanin and phycocyanobilin have high anti-inflammatory efficacy, even compared to the group that received mesalazine. [155] 𝛽-Carotene, which belongs to the carotenoid family, is provitamin A, which plays a central role in the regulation of physiological functions in the living body and is synthesized by a large variety of microalgae. [156] The positive and anti-inflammatory effects of 𝛽-carotene have been observed in many studies both in vitro and in vivo, [157] and these effects seem to be applicable as a treatment for IBD.…”

Section: Protective Effects Of Microalgal Proteins Peptides and Bioac...mentioning

confidence: 99%

Microalgae—Sustainable Source for Alternative Proteins and Functional Ingredients Promoting Gut and Liver Health

et al. 2023

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Dietary proteins derived from animal sources, although containing well‐balanced profiles of essential amino acids, have considerable environmental and adverse health effects associated with the intake of some animal protein‐based products. Consuming foods based on animal proteins carries a higher risk of developing non‐communicable diseases such as cancer, heart disease, non‐alcoholic fatty liver disease (NAFLD), and inflammatory bowel disease (IBD). Moreover, dietary protein consumption is increasing due to population growth, posing a supply challenge. There is, therefore, growing interest in discovering novel alternative protein sources. In this context, microalgae have been recognized as strategic crops that can provide a sustainable source of protein. Compared to conventional high‐protein crops, using microalgal biomass for protein production presents several advantages in food and feed in terms of productivity, sustainability, and nutritional value. Moreover, microalgae positively impact the environment by not exploiting land or causing water pollution. Many studies have revealed the potential of microalgae as an alternative protein source with the added value of positive effects on human health due to their anti‐inflammatory, antioxidant, and anti‐cancer properties. The main emphasis of this review is on the potential health‐promoting applications of microalgae‐based proteins, peptides, and bioactive substances for IBD and NAFLD.

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Phycocyanin ameliorates mouse colitisviaphycocyanobilin-dependent antioxidant and anti-inflammatory protection of the intestinal epithelial barrier

Abstract: Phycocyanin is a typical microalgal active compound with antioxidant and anti-inflammatory efficacy, and the pigment moiety phycocyanobilin has been recently proposed as its active structural component. Here, to explore the...

Cited by 35 publications

References 50 publications

Amelioration of dextran sulfate sodium-induced colitis by autoinducer-2-deficient Lactiplantibacillus plantarum is mediated by anti-inflammatory effects and alleviation of dysbiosis of the gut microbiota

Amelioration of dextran sulfate sodium-induced colitis by autoinducer-2-deficient Lactiplantibacillus plantarum is mediated by anti-inflammatory effects and alleviation of dysbiosis of the gut microbiota

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

Microalgae—Sustainable Source for Alternative Proteins and Functional Ingredients Promoting Gut and Liver Health

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