Phycocyanin liposomes for topical anti-inflammatory activity: in-vitro in-vivo studies

Manconi, Maria; Pendás, Jehzabel; Ledón, Nurys; Moreira, Tomás Antônio; Sinico, Chiara; Saso, Luciano; Fadda, Anna Maria

doi:10.1211/jpp/61.04.0002

Cited by 23 publications

(14 citation statements)

References 38 publications

(41 reference statements)

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“…The antioxidant and antiinflammatory properties of phycocyanin were first reported in 1998 [80, 81] and confirmed by numerous studies thereafter [20, 82–92]. Phycocyanin has the ability to scavenge free radicals, including alkoxyl, hydroxyl and peroxyl radicals.…”

Section: Mechanism Of Actionmentioning

confidence: 95%

“…Phycocyanin has the ability to scavenge free radicals, including alkoxyl, hydroxyl and peroxyl radicals. It also decreases nitrite production, suppresses inducible nitric oxide synthase (iNOS) expression, and inhibits liver microsomal lipid peroxidation [20, 80–92]. Using recombinant technology, phycocyanin protein has been expressed and the antioxidant activity is also demonstrated with the recombinant phycocyanin protein [93, 94].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

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Hypolipidemic, Antioxidant, and Antiinflammatory Activities of Microalgae Spirulina

Deng

Chow

2010

Cardiovascular Therapeutics

377

229

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SUMMARYSpirulina is free-floating filamentous microalgae growing in alkaline water bodies. With its high nutritional value, Spirulina has been consumed as food for centuries in Central Africa. It is now widely used as nutraceutical food supplement worldwide. Recently, great attention and extensive studies have been devoted to evaluate its therapeutic benefits on an array of diseased conditions including hypercholesterolemia, hyperglycerolemia, cardiovascular diseases, inflammatory diseases, cancer, and viral infections. The cardiovascular benefits of Spirulina are primarily resulted from its hypolipidemic, antioxidant, and antiinflammatory activities. Data from preclinical studies with various animal models consistently demonstrate the hypolipidemic activity of Spirulina. Although differences in study design, sample size, and patient conditions resulting in minor inconsistency in response to Spirulina supplementation, the findings from human clinical trials are largely consistent with the hypolipidemic effects of Spirulina observed in the preclinical studies. However, most of the human clinical trials are suffered with limited sample size and some with poor experimental design. The antioxidant and/or antiinflammatory activities of Spirulina were demonstrated in a large number of preclinical studies. However, a limited number of clinical trials have been carried out so far to confirm such activities in human. Currently, our understanding on the underlying mechanisms for Spirulina's activities, especially the hypolipidemic effect, is limited. Spirulina is generally considered safe for human consumption supported by its long history of use as food source and its favorable safety profile in animal studies. However, rare cases of side-effects in human have been reported. Quality control in the growth and process of Spirulina to avoid contamination is mandatory to guarantee the safety of Spirulina products.

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Section: Mechanism Of Actionmentioning

confidence: 95%

Section: Mechanism Of Actionmentioning

confidence: 99%

Hypolipidemic, Antioxidant, and Antiinflammatory Activities of Microalgae Spirulina

Deng

Chow

2010

Cardiovascular Therapeutics

377

229

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“…(+)‐Catechin and (–)‐epicatechin are also the building blocks of most proanthocyanins (oligomers or polymers of flavan‐3‐ol units) [14] . Besides the classical biological and pharmacological activities described for several flavonoids, such as anti‐inflammatory and antioxidant properties, [15,16] many studies have reported their effects on the central nervous system (CNS) as analgesics, anxiolytics and sedatives [16,17] …”

Section: Introductionmentioning

confidence: 99%

Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats

Moreira

Rial

Duarte

et al. 2010

Journal of Pharmacy and Pharmacology

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“…[29][30][31][32] Here, we are giving some reference to support above statements. Fadda et al [36] developed phycocyanin loaded liposomes by the film hydration techniques. They reported that phycocyanin (C-Pc) loaded liposomes were adsorbed on stratum corneum and accumulated C-Pc on stratum corneum.…”

Section: Liposomes As Carrier For Dermal Drug Delivery Systemsmentioning

confidence: 99%

Untitled

Madhavi

2016

AJP

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Aim: The aim of the present work was to focus on the applicability of liposomes and ethosomes for transdermal delivery. In the current review, we had focused on transdermal delivery transdermal delivery of vesicular system vesicular systems, i.e., liposome and ethosomes, factors affecting their permeation and penetration efficiency, limitations, applications, method of preparations, evaluation parameters, and selection of lipids. In this review, we considered the mechanism of controlled drug release of vesicles by transdermal delivery and the impact of their physicochemical properties. Rheumatoid arthritis (RA) is most frequently suffering disease in the geriatric population. By transdermal delivery, conventional anti-RA (ARA) therapy associated with several disadvantages. The modern ARA therapy; disease-modifying antirheumatic drugs (DMARDs) are more effective in reducing down disease progression. The basic mechanism of action of DMARDs in RA is not clear. The vesicles have a potential role in RA; especially, we focused on the impact of liposomes and ethosomes on RA by transdermal delivery, vesicular mechanism to justification in ARA therapy. Conclusion: The liposomes and ethosomes were beneficial tools for transdermal delivery. They have a potential role to control RA by transdermal delivery.

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Phycocyanin liposomes for topical anti-inflammatory activity: in-vitro in-vivo studies

Abstract: The results showed that C-PC can be successfully used as an anti-inflammatory drug and that liposomal encapsulation is effective in improving its anti-inflammatory activity.

Cited by 23 publications

References 38 publications

Hypolipidemic, Antioxidant, and Antiinflammatory Activities of Microalgae Spirulina

Hypolipidemic, Antioxidant, and Antiinflammatory Activities of Microalgae Spirulina

Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats

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