Phyllanthus amarus attenuated derangement in renal-cardiac function, redox status, lipid profile and reduced TNF-α, interleukins-2, 6 and 8 in high salt diet fed rats

Olorunnisola, Olubukola Sinbad; Fadahunsi, Olumide Samuel; Adegbola, Peter Ifeoluwa; Ajilore, Bamidele Stephen; Ajayi, Ayodeji Folorunsho; Olaniyan, Lamidi W. B.

doi:10.1016/j.heliyon.2021.e08106

Cited by 5 publications

(2 citation statements)

References 54 publications

(46 reference statements)

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“…Studies have shown that extracts of P. amarus confer cardiovascular protection. Olorunnisola et al [50] showed that ethanol extracts of P. amarus displayed considerable cardio protection against high salt-diet that may lead to cardiovascular disease. Its hypolipidaemic activity has also been reported [51].…”

Section: Discussionmentioning

confidence: 99%

Nutriphytochemical Profiling and Changes in Cardiovascular Risk Index in Malarial Infected Mice Treated with Ethanol Root Extract of Phyllanthus Amarus

Opajobi,

Uzuegbu,

Olawale

et al. 2023

ijmst

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Purpose: The use of medicinal plants in malarial treatment has become popular in Nigeria, an endemic country, due to failing chemotherapy and high cost of antimalarial drugs. One of such commonly used herbs is Phyllanthus amarus. The antimalarial activity of P. amarus has been consistently reported, giving credence to its traditional use. Nevertheless, effects of such treatment on reducing cardiovascular risk indices is yet to be fully documented. This is imperative since certain metabolic complications like increased plasma lipids have been associated with considerable risks of fatty liver and cardiovascular diseaes in severe cases of malaria in humans. Methods: In this present study, therefore, the antiplasmodial action of the ethanol root extract of P. amarus and its ED50 dose were determined and associated cardiovascular risk indices were evaluated in BALB/c malarial infected mice, having ascertained the nutritive quality and phytochemicals of plant root. Results: Results showed that P. amarus root is abundant in alkaloid phytochemical and the roots extracts demonstrated significant antiplasmodial activity in a dose-dependent trend with optimal ED50 and maximal potency in reducing cardiovascular risk indices (Atherogenic index of plasma, AIP and heart disease risk, HDR) and fatty liver, which compared well with the values obtained from the uninfected control mice. Conclusion: The roots of P. amarus possess a wide array of nutrients and phytochemicals, with significant antimalarial activity. The roots also reduced the risks of cardiovascular diseases associated with severe malaria, in experimental mice.

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Section: Discussionmentioning

confidence: 99%

Nutriphytochemical Profiling and Changes in Cardiovascular Risk Index in Malarial Infected Mice Treated with Ethanol Root Extract of Phyllanthus Amarus

Opajobi,

Uzuegbu,

Olawale

et al. 2023

ijmst

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“…Phyllanthus amarus , belonging to the family Euphorbiaceae, is an annual tropical plant known for its various medicinal benefits in folkloric medicine. According to reports, P. amarus exhibits numerous medicinal properties, including antihepatitis, antimalarial, anticarcinogenic, antiasthmatic, antiviral, antibacterial, antidiarrheal, hepatoprotective, anti-inflammatory, and antidiabetic properties (Ogunmoyole et al, 2020 ; Olorunnisola et al, 2021 ). Additionally, the use of Annona muricata is well-documented for addressing conditions such as cancer, fever, hemolysis, respiratory illness, malaria, gastrointestinal problems, liver, heart, and kidney affections, hypoglycemia, hypotension, and cancer (Gavamukulya et al, 2017 ; Badmus et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Storage and time course effects on the quality of oil extracted from Phyllanthus amarus Schumach and Annona muricata Linn and their antidiabetic potentials

Ogunjinmi,

Oriyomi,

Olaogun

et al. 2024

bta

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With the advent of modern technology, advancements in processing and storage techniques, and increasing medical knowledge, people are becoming aware of deterioration in the quality of medicinal products due to storage methods and time. In most cases, herbal products are not consumed immediately after production; as such, improper storage can result in physical, chemical, and microbiological changes. The study evaluated the effect of storage methods and time on the quality of oil extracted from Phyllanthus amarus Schumach and Annona muricata Linn and assessed their antidiabetic and antioxidative effects. Plants were air-dried, pulverized, and then subjected to Soxhlet extraction in petroleum ether. The oil was evaluated for phytochemical constituents and the effects of time and storage methods on its physicochemical properties. Characterization of the oil was done by spectroscopic techniques. Oils from both plants contained tannins, flavonoids, alkaloids, steroids, glycosides, terpenoids, phlobotannins, resins, reducing sugar, phenols, and saponins in different proportions. The oil from A. muricata had higher phenolic (3.11 ± 0.31 mg GAE/g), flavonoid (11.82 ± 0.08 mg QUE/g), alkaloid (16.37 ± 0.56 mg APE/g), and tannin (7.13 ± 0.47 mg CE/g) contents than the oil from P. amarus , which had 0.54 ± 0.08 mg GAE/g, 7.83 ± 0.13 mg QUE/g, 9.87 ± 0.15 mg APE, and 3.16 ± 0.12 mg CE/g for total phenolic, flavonoids, alkaloids, and tannins, respectively. Initial acid, iodine, peroxide, and saponification values recorded for P. amarus were 5.63 ± 0.82 mg KOH/g, 97.17 ±0.53 Wijis, 9.31 ± 0.15 mEq/kg, and 116.11 ± 0.74 mg KOH/g, respectively, significantly different from those of A. muricata , which had values of 1.17 ± 0.08 mg KOH, 76.23 ± 0.03 Wijis, 6.75 ± 0.47 mEq/kg, and 193.31 ± 0.52 mg KOH/g, respectively. FT-IR characterization of the oils revealed the presence of carboxylic acid, alkyl, alkene, alkane, haloalkane, aldehyde, aromatic amine, α-unsaturated and β-unsaturated esters, and phenol functional groups. P. amarus oil inhibited α-amylase (IC 50 0.17 ± 0.03 mg/ml), α-glucosidase (IC 50 0.64 ± 0.03 mg/ml), and xanthine oxidase (0.70 ± 0.01 mg/ml) to a greater extent than A. muricata oil, with IC 50 values of 0.43 ± 0.05 mg/ml (α-amylase), 2.25 ± 0.31 mg/ml (α-glucosidase), and 0.78 ± 0.07 mg/ml (xanthine oxidase). This study showed that oils from the tested plants have low rancidity with a moderate shelf life. The extracts contained essential phytoconstituents that significantly inhibited α-glucosidase and xanthine oxidase. These effects of the oil indicate their potential to prevent diabetes, gout, and oxidative stress. Consequently, the supply of P. amarus and A. muricata in homemade diets is strongly encouraged fo...

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An insight into the potent medicinal plant Phyllanthus amarus Schum. and Thonn.

Ghosh

Banerjee

Chattopadhyay

2022

Nucleus

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Phyllanthus amarus attenuated derangement in renal-cardiac function, redox status, lipid profile and reduced TNF-α, interleukins-2, 6 and 8 in high salt diet fed rats

Cited by 5 publications

References 54 publications

Nutriphytochemical Profiling and Changes in Cardiovascular Risk Index in Malarial Infected Mice Treated with Ethanol Root Extract of Phyllanthus Amarus

Nutriphytochemical Profiling and Changes in Cardiovascular Risk Index in Malarial Infected Mice Treated with Ethanol Root Extract of Phyllanthus Amarus

Storage and time course effects on the quality of oil extracted from Phyllanthus amarus Schumach and Annona muricata Linn and their antidiabetic potentials

An insight into the potent medicinal plant Phyllanthus amarus Schum. and Thonn.

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