Phyllodes tumor in an adolescent female

Baldiwala, Aafrin S.; Vaidya, Hiren P.

doi:10.18203/2349-2902.isj20214393

Cited by 2 publications

(2 citation statements)

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“…When a PT has a diameter above 10 cm, it can be classified as a giant PT [ 12 ]. Most of the cases in our review presented local signs of inflammation, venous congestion [ 13 , 14 ], bleeding [ 10 , 15 , 16 ], “peau d’orange” [ 17 , 18 ] or even necrosis or skin ulcers [ 7 , 10 , 14 , 15 , 16 , 19 , 20 , 21 ] while others had no other clinical manifestation than the enlargement of the affected breast [ 22 , 23 , 24 , 25 ]. Local complications are attributed to the increased pressure that the rapid tumoral growth exerts on the skin but can be difficult to interpret since they are encountered also in malignancy [ 26 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

Diagnostic difficulties in giant benign phyllodes tumor

Matei

Mehedinţu-Ionescu²,

Paitici³

et al. 2022

Rom J Morphol Embryol

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Phyllodes tumors (PTs) are rare tumors of the breast, which encompass both stromal and epithelial components. The maximum incidence is in the fourth decade of life. Most of these tumors are benign, but about one third can be malignant acting as sarcomas. Due to their rarity and atypical clinical behavior (especially for the giant ones), the management of these tumors is usually difficult. We report a case of a 24-year-old woman who presented in the Department of Oncology for rapid increase in volume of the left breast. She had no personal pathological or family history. Initial clinical exam showed a large irregular mass in the left breast of approximately 30 cm and palpable lymph nodes in the ipsilateral axilla. A core needle biopsy for the tumor was performed with histopathological (HP) result that revealed an aspect suggesting fibroadenoma/PT. Contrast-enhanced computed tomography (CT) scan identified lymph node enlargement in the left axilla and a peripheral nodule in the lung about 5.5/3.4 mm with no specific features. The patient was then transferred to the Department of Surgery, where left mastectomy and axillary lymph node sampling were performed. HP result of the surgical specimens confirmed the presence of both fibroadenoma and PT, with clear margins above 1 cm, but recommended immunohistochemistry (IHC) to clearly specify benign versus borderline type. Five lymph nodes out of six resected presented microscopic reactive changes. We performed a search of literature using the keywords "giant", "benign" and "phyllodes". The results were used to summarize and discuss some of the main features of this type of tumors as well as diagnostic and therapeutic difficulties.

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Section: ⧉ Discussionmentioning

confidence: 99%

Diagnostic difficulties in giant benign phyllodes tumor

Matei

Mehedinţu-Ionescu²,

Paitici³

et al. 2022

Rom J Morphol Embryol

View full text Add to dashboard Cite

show abstract

“…Phyllodes tumor is a rare tumor of the breast comprising <1 % of all breast tumors, seen in women between the ages of 35 to 55 years of age [1] . These fibro-epithelial breast tumors take their name from the Greek word phyllon meaning leaf-like as a result of their histological appearance [2] , [3] . In 2012 WHO classification of breast tumors the term Phyllodes was selected to describe these breast tumors which range from benign to borderline to malignant types of Phyllodes with borderline comprising 7–40 % and malignant phyllodes comprising up to 30 % [4] , [5] .…”

Section: Introductionmentioning

confidence: 99%