Phyllodes Tumor of Vulva: A Brief Diagnostic Review

Abstract

Phyllodes tumors of the vulva are rare proliferations that share morphologic similarities with breast neoplasms. Their histogenetic origin is elusive and may be associated with specialized mammary-like glands of the vulva. Because of their rarity, the clinical and pathologic features, classification, and therapy are not well defined, and their biologic behavior is difficult to predict by histology alone. Immunohistochemical expression of estrogen and progesterone receptors and breast markers provide further support for a common origin. Surgical resection is the current mainstay of therapy and is definitive in most cases.

Phyllodes tumour of the labia minora

“…Their rate of growth is variable, with some presenting with recent rapid growth and others being present with little growth for many years 13 14. The majority of lesions are located in the labia majora but have been described to also occur in the interlabial sulcus, pericliteral and on the mons 13. Our case is the first reported case, which we could find, of a phyllodes tumour occurring in the labia minora.…”

“…Phyllodes tumours are primarily found in the breast although they may rarely present in the vulva as solitary, well-circumscribed, skin-coloured tumours which are freely mobile and non-tender to the touch. Their rate of growth is variable, with some presenting with recent rapid growth and others being present with little growth for many years 13 14. The majority of lesions are located in the labia majora but have been described to also occur in the interlabial sulcus, pericliteral and on the mons 13.…”

“…Ectopic mammary tissue in the vulva was long thought to represent the caudal remnants of the mammary ridges. However, recent studies are proposing that anogenital mammary-like glands are a normal constituent of the anogenital area 13–15…”

“…Seventeen previously reported cases of vulvar phyllodes tumours have been reported in the literature2–12; however, our case represents the first reported tumour located in the labia minora. As these tumours are rarely found in the vulva, treatment and prognosis is less established13; we discuss the differential diagnosis, treatment and surveillance to be considered for these rare tumours.…”

Anogenital mammary-like glands and related lesions. Part 1. Benign tumors and tumor-like disorders

“…Особенности листовидной опухоли заключаются в появлении листовидных структур -истинных сосочков на широком основании, покрытых эпителием и вдающихся в просветы кистовидно увеличенных железистых полостей, и гиперцеллюлярности стромы. Листовидные опухоли в области вульвы встречаются чрезвычайно редко [42][43][44][45][46][47]. В нескольких случаях визуализировались структуры, напоминающие МПЖ [42][43][44][45].…”