Phyllodes tumors of the breast: The British Columbia Cancer Agency experience

Rodrigues, Myra; Truong, Pauline T.; McKevitt, Elaine; Weir, Lorna; Knowling, Margaret A.; Wai, Elaine S.

doi:10.1016/j.canrad.2017.08.112

Cited by 38 publications

(34 citation statements)

References 21 publications

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“…In 2009, the results of 13 studies were summarized: 12/50 patients (24%) with borderline PTs and 25/124 patients (20%) with malignant PTs locally recurred after margin-negative BCS. 2 [3][4][5][6][7] Combining these results with the 13 previous studies identified 140 LRs in 685 patients, a 20.4% LR rate in patients with borderline or malignant PTs undergoing BCS with negative margins.…”

supporting

confidence: 69%

Borderline and Malignant Phyllodes Tumors: How Often do They Locally Recur and is There Anything we can do About it?

Barth

2019

Ann Surg Oncol

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supporting

confidence: 69%

Borderline and Malignant Phyllodes Tumors: How Often do They Locally Recur and is There Anything we can do About it?

Barth

2019

Ann Surg Oncol

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“…A study of 164 cases of PTs ( 18 ) showed that the length of the margin is not associated with local recurrence, whereas a positive margin is related to recurrence. Another study of 183 cases of PTs ( 19 ) also suggested that the size of the surgical margin is not linked to local recurrence. Noordman PCW et al.…”

Section: Discussionmentioning

confidence: 99%

A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review

et al. 2021

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Phyllodes tumor (PT) is a special type of breast tumors, including three types: malignant, borderline, and benign. Most of these tumors form unilateral disease and can rapidly increase in size. The occurrence of axillary lymph node metastasis is rare. Tumor-associated hypoglycemia can be divided into non-islet cell tumor and insulinoma. In non-islet cell tumor hypoglycemia (NICTH), a considerable high molecular weight form of insulin like growth factor 2 (IGF-2) is formed, which abnormally binds to insulin receptors in the tissues and causes hypoglycemia. Breast phyllodes tumors with NICTH are rare and first reported in 1983. Surgical resection is the main treatment and hypoglycemia symptoms usually resolve after surgery. Nevertheless, prior to surgery, intravenous glucose infusion is used to maintain blood glucose levels. A female patient presented with a rapidly growing breast mass and was diagnosed with a phyllodes tumor with NICTH at our hospital in August 2020; she was successfully treated through surgical resection. We reviewed the relevant literature to investigate and analyze the relationship between NICTH and phyllodes tumors, as well as optimize its diagnosis and treatment.

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“…The limitations of the current study include its retrospective design subject to inherent selection biases, small samples due to disease rarity, and relatively short follow-up time. In a study from the same institution of 183 cases of PT with a median follow-up time of 65 months, local recurrence was observed in 8.7%, distant metastases in 4.4%, and cause-specific deaths in 3.8% [ 23 ]. Among the 11 cases examined in the current analysis, no recurrence or cancer-specific deaths were observed at a mean follow-up of 54 months, suggesting that recurrence and survival outcomes were not inferior relative to PT without malignant epithelial transformation.…”

Section: Discussionmentioning

confidence: 99%

Malignant Epithelial Transformation in Phyllodes Tumor: A Population-Based Case Series

Widya

Rodrigues

Truong

et al. 2017

Cureus

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BackgroundPhyllodes tumor (PT) of the breast is an uncommon fibroepithelial neoplasm. Malignant epithelial transformation in PT is rare. This study reports clinicopathologic characteristics and outcomes of patients with malignant epithelial transformation in PT.MethodsFrom an institutional database of 183 patients with newly diagnosed PT referred to a Canadian provincial cancer institution between 1999 and 2014, 11 cases of PT with concomitant in situ or invasive carcinoma were identified. Descriptive analysis was performed to document the characteristics, treatment and outcomes of this cohort.ResultsPrevalence of malignant epithelial transformation in PT was 6.0%. Median (range) age was 54 (35–75) years. Types of carcinoma were ductal carcinoma in situ (DCIS) (n = 6), lobular carcinoma in situ (n = 4), and invasive ductal carcinoma (IDC) (n = 1). Median PT size was 5 (1–15) cm. Three PTs were classified as benign (27%), five as borderline (45%), and three as malignant (27%). Mastectomy was performed in six (55%) and breast conserving surgery in five (45%) patients. Hormonal therapy was used in two cases: one with a 1 cm, grade 2 DCIS, and one with an 11 cm, grade 1 IDC, the latter also receiving radiotherapy. Mean follow-up duration was 54 (6–175) months. None of the cases showed any evidence of disease after treatment at the time of their last follow-up.ConclusionThis case series showed a higher prevalence of malignant epithelial transformation in PT than reported in previous literature. Outcomes were favourable despite the presence of either in situ or invasive carcinoma within PT.

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Phyllodes tumors of the breast: The British Columbia Cancer Agency experience

Cited by 38 publications

References 21 publications

Borderline and Malignant Phyllodes Tumors: How Often do They Locally Recur and is There Anything we can do About it?

Borderline and Malignant Phyllodes Tumors: How Often do They Locally Recur and is There Anything we can do About it?

A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review

Malignant Epithelial Transformation in Phyllodes Tumor: A Population-Based Case Series

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