Phylogenetic Analysis of Neuraminidase Genes of H5N1 Isolates using HPC Technologies

Singh, Daljit; Trehan, Rahul; Ray, Pratima; Schmidt, Bárbara

doi:10.1109/health.2007.381652

Cited by 1 publication

(1 citation statement)

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“…Distribution of files is then implemented by using a demultiplexer ( Demux ) component and a result combining module ( Concat ). More technical details about the file distribution and concatenation as well as other workflow parameters can be found elsewhere [ 23 ]. The model, design and implementation used to distribute the distance-based workflow can also be applied to parallelize the parsimony and the ML based workflows.…”

Section: Methodsmentioning

confidence: 99%

Comparative phyloinformatics of virus genes at micro and macro levels in a distributed computing environment

Singh¹,

Trehan

Schmidt

et al. 2008

BMC Bioinformatics

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Background: Preparedness for a possible global pandemic caused by viruses such as the highly pathogenic influenza A subtype H5N1 has become a global priority. In particular, it is critical to monitor the appearance of any new emerging subtypes. Comparative phyloinformatics can be used to monitor, analyze, and possibly predict the evolution of viruses. However, in order to utilize the full functionality of available analysis packages for largescale phyloinformatics studies, a team of computer scientists, biostatisticians and virologists is needed -a requirement which cannot be fulfilled in many cases. Furthermore, the time complexities of many algorithms involved leads to prohibitive runtimes on sequential computer platforms. This has so far hindered the use of comparative phyloinformatics as a commonly applied tool in this area.

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Section: Methodsmentioning

confidence: 99%