Phylogenetic analysis of the haemagglutinin gene of canine distemper virus strains detected from breeding foxes, raccoon dogs and minks in China

Jian-jun, Zhao; Yan, Xijun; XiuLi, Chai; Martella, Vito; Luo, Guoliang; Zhang, Hailing; Gao, Han; Liu, Yingxue; Bai, Xiaoshuan; Zhang, Lei; Chen, Tao; Liu, Xu; Chun-fei, Zhao; Wang, Fengxue; Shao, Xiqun; Wu, Wei; Cheng, Shipeng

doi:10.1016/j.vetmic.2009.07.010

Cited by 94 publications

(90 citation statements)

References 39 publications

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“…Direct contact with nasal, oral secretions or urine of infected animals is the major route of CDV transmission. Recently, outbreaks of distemper have been identified in dogs and an increasing number of host species, which has been the subject of many studies to elucidate the potential mutations and viral mechanisms that may be involved in host susceptibility (ZHAO et al, 2010;MEGID et al, 2013;DI SABATINO et al, 2014). Clinical signs of canine distemper consist of respiratory and/ or gastrointestinal symptoms that may or may not be associated with neurological symptoms (CARVALHO et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Canine distemper virus detection by different methods of One-Step RT-qPCR

et al. 2016

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Three commercial kits of One-Step RT-qPCR were evaluated for the molecular diagnosis of Canine Distemper Virus. Using the kit that showed better performance, two systems of Realtime RT-PCR (RT-qPCR) assays were tested and compared for analytical sensitivity to Canine Distemper RESUMO Três kits comerciais de One-Step RT-qPCR foram avaliados para o diagnóstico molecular do Vírus da Cinomose Canina.Utilizando o kit que apresentou melhor desempenho, dois sistemas de RT-PCR em tempo real (RT-qPCR) foram comparados quanto à sensibilidade analítica na detecção do RNA do Vírus da Cinomose Canina:One-Step RT-qPCR (Sistema A) e One-Step RT-qPCR seguido da NESTED-qPCR (Sistema B).Os limites de detecção dos dois sistemas foram determinados utilizando diluição

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Section: Introductionmentioning

confidence: 99%

Canine distemper virus detection by different methods of One-Step RT-qPCR

et al. 2016

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“…Canine distemper (CD) is a highly contagious disease and is transmitted by aerosols/droplets causing an acute disease characterized by generalized rash, respiratory and gastrointestinal signs, and immunosuppression, with occasional neurological complications [2,30]. It infects most members of the order Carnivora, wild and domestic, but with different susceptibilities and mortalities [31]. Infection can be controlled only by vaccination [4].…”

Section: Introductionmentioning

confidence: 99%

A recombinant canine distemper virus expressing a modified rabies virus glycoprotein induces immune responses in mice

Wang

Ding

et al. 2015

Virus Genes

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Canine distemper virus (CDV) and rabies virus (RV) are two important pathogens of the dog. CDV, a member of the morbillivirus genus, has shown promise as an expression vector. The glycoprotein from RV is a main contributor to protective immunity and capable of eliciting the production of virus-neutralizing antibodies. In this study, we recovered an attenuated strain of canine distemper virus and constructed a recombinant virus, rCDV-RV-G, expressing a modified (R333Q) rabies virus glycoprotein (RV-G) of RV Flury strain LEP. RV-G expression by the recombinant viruses was confirmed. Furthermore, G was proved to be incorporated into the surface of CDV particles. While replication of the recombinant virus was slightly reduced compared with the parental CDV, it stably expressed the RV-G over ten serial passages. Inoculation of mice induced specific neutralizing antibodies against both RV-G and CDV. Therefore, the rCDV-RV-G has the potential as a vaccine that may be used to control rabies virus infection in dogs and other animals.

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“…In addition, some CDV strains identified in Africa, Asia and Argentina (Gallo et al 2007;Woma et al 2010;Zhao et al 2010) appear to diverge substantially and might represent separate geographic groups. Besides the vaccines grouped in America-1 genotype there are some independent strains used as vaccines which are related to Rockborn strain (Martella et al 2011).…”

Section: Introductionmentioning

confidence: 99%