Phylogenetic aspects of the neuroepithelial bodies.

Rogers, D. C.

doi:10.1679/aohc.52.suppl_397

Cited by 12 publications

(8 citation statements)

References 33 publications

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“…By transmission electronmicroscopy five different types of nerve fibres have been recognised in the vicinity of NEBs in mammals (Rogers 1989). In the present study we failed to show an IR towards 5-HT, Galanin, VIP, SP and CGRP (Table I), and the identity of the acetylated a-tubulin-like IR nerve fibres surrounding the aggregated NECs in cod is therefore still unknown.…”

Section: Resultsmentioning

confidence: 99%

The Oxygen Receptor of the Teleost Gill?

1998

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Sundin. L. Holmgren, S. & Nilsson. S. 1998. The oxygen receptor of the teleost gill?-Acra Zoologicu (Stockholm) 7 9 207-214.The gills of the Atlantic cod, Gadus morhua. were studied using immunohistochemical techniques. Primary antibodies directed against serotonin (5-hydroxytryptamine, 5-HT) and acetylated a-tubulin were used to visualise cells containing serotonin and nerve fibres, respectively. Three morphologically different 5-HT immunoreactive cell types were distinguished: (I) Neuroepithelial cells (NECs), which were abundant along the distal half of the efferent filamental arteries (EFAs), and particularly formed distinct clusters at the individual filamental tips, (11) bipolar neurones running next to the EFAs and (Ill) multipolar neurones innervating the proximal parts of the EFA. In addition, the study revealed a well-developed system of nerve fibres, some of which form plexuses in association with the NECs. A relatively rich innervation of the proximal part of the EFAs, in conjunction with the EFA sphincters was also observed. Delicate varicose terminals surround the bases of the efferent lamellar arterioles. The localisation of distinct clusters of NECs at the individual filamental tips and the close connection with nerve terminals suggests a function as external branchial oxygen receptors.

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Section: Resultsmentioning

confidence: 99%

The Oxygen Receptor of the Teleost Gill?

1998

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“…These epithelial organoids, located in the human lung by Lauweryns & Peuskens (i972), are found also in metatherian mammals (Hailer, 1992), monotremes (Hailer, personal communication), birds (Cook & King, 1969;King et al, 1974), chelonians (see Scheuermann, 1987) and amphibians (see Rogers, 1989).…”

Section: Structure and Distribution Of Single Endo-crine Cells And Nementioning

confidence: 96%

“…Reviews dealing with bronchopulmonary paraneurons, mainly in mammals but also encompassing other groups, include Scheuermann (1987), Fujita et al (1988), Sorokin & Hoyt (1989) and Rogers (1989).…”

Section: The Paraneuronal Endocrine Cell System In the Airways Of Higmentioning

confidence: 99%

Distribution patterns of the paraneuronal endocrine cells in the skin, gills and the airways of fishes as determined by immunohistochemical and histological methods

1994

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The neuro-endocrine cells of fish skin and respiratory surfaces, and their bioactive secretion as far as is known, are reviewed, and compared with similar elements in tetrapods, particularly amphibians. In the skin of teleost fish, immunohistochemistry has shown that Merkel cells react for serotonin, neuron-specific enolase and enkephalins. The pharmacology is not established in dipnoans or lampreys. In some teleosts, neuromasts react for substance P and leu-enkephalins; substance P is also reported from some ampullary organs (electroreceptors). Taste buds of teleosts may react for enkephalin and substance P. Basal cells of taste buds react for serotonin and neuron-specific enolase. Some unicellular skin glands of teleosts express bioactive compounds, including serotonin and some peptides; this ectopic expression is paralleled in amphibian skin glands. The dipnoan Protopterus has innervated pulmonary neuro-endocrine cells in the pneumatic duct region with dense-cored vesicles. In Polypterus and Amia the lungs have serotonin-positive neuro-endocrine cells that are apparently not innervated. In fish gills, a closed type of neuro-endocrine cell reacts for serotonin, an open type for enkephalins and some calcium-binding proteins (calbindin, calmodulin and S-100 protein). The functions of neuro-endocrine cells in fishes await investigation, but it is assumed they are regulatory.

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“…9 The structural differences between the lung PNEC system of primitive phyla (amphibians, reptiles) and advanced (birds, mammals) organisms are minor, suggesting a long-standing and fundamentally relevant physiological function.…”

Section: Neuroendocrine System Of the Lungmentioning

confidence: 99%

Bronchopulmonary neuroendocrine tumors

Gustafsson

Kidd

Chan

et al. 2008

Cancer

446

340

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SCLC is the most common BP-NET, while LCNEC is rare, %10% and 1%, respectively, of all lung cancers. Both SCLC and LCNEC progress rapidly, are aggressively metastatic, and exhibit a poor prognosis. The incidence of BP-carcinoids (TC and AC) in the US was 1.57 of 100,000 in 2003 (an unexplained and substantial increase over the last 30 years, %6% per year). No curative treatment except for radical surgery (almost never feasible) exists. The slow-growing TC exhibit a fairly good prognosis (%88%, 5-year survival), whereas AC demonstrate a 5-year survival of %50%, and the highly malignant LCNEC and SCLC 5-year survival of 15% to 57% and <5%, respectively. This review provides a broad overview on BPNETs and focuses on the evolution of the disease, general features, and current diagnostic and therapeutic options.

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Phylogenetic aspects of the neuroepithelial bodies.

Cited by 12 publications

References 33 publications

The Oxygen Receptor of the Teleost Gill?

The Oxygen Receptor of the Teleost Gill?

Distribution patterns of the paraneuronal endocrine cells in the skin, gills and the airways of fishes as determined by immunohistochemical and histological methods

Bronchopulmonary neuroendocrine tumors

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