2023
DOI: 10.1371/journal.pcbi.1011404
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Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family

Olivier Dennler,
François Coste,
Samuel Blanquart
et al.

Abstract: Numerous computational methods based on sequences or structures have been developed for the characterization of protein function, but they are still unsatisfactory to deal with the multiple functions of multi-domain protein families. Here we propose an original approach based on 1) the detection of conserved sequence modules using partial local multiple alignment, 2) the phylogenetic inference of species/genes/modules/functions evolutionary histories, and 3) the identification of co-appearances of modules and … Show more

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