Phylogenetic memory of developing mammalian dentition

Peterková, Renata; Lesot, Hervé; Peterka, Miroslav

doi:10.1002/jez.b.21093

Cited by 96 publications

(112 citation statements)

References 53 publications

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“…It has been proposed that atavistic structures can only arise when a rudiment has been retained (27). In addition, the supernumerary teeth in Eda-overexpressing mice are thought to arise by rescue of a rudimentary tooth germ (28). We therefore examined whether the ability of Eda to restore lost upper pharyngeal teeth is dependent on the presence of rudiments in the upper pharynx.…”

Section: Eda Overexpression Restores Teeth To the Upper Pharynx Of Thementioning

confidence: 99%

Selection and constraint underlie irreversibility of tooth loss in cypriniform fishes

Aigler

Jandzík

Hatta

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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The apparent irreversibility of the loss of complex traits in evolution (Dollo's Law) has been explained either by constraints on generating the lost traits or the complexity of selection required for their return. Distinguishing between these explanations is challenging, however, and little is known about the specific nature of potential constraints. We investigated the mechanisms underlying the irreversibility of trait loss using reduction of dentition in cypriniform fishes, a lineage that includes the zebrafish (Danio rerio) as a model. Teeth were lost from the mouth and upper pharynx in this group at least 50 million y ago and retained only in the lower pharynx. We identified regional loss of expression of the Ectodysplasin (Eda) signaling ligand as a likely cause of dentition reduction. In addition, we found that overexpression of this gene in the zebrafish is sufficient to restore teeth to the upper pharynx but not to the mouth. Because both regions are competent to respond to Eda signaling with transcriptional output, the likely constraint on the reappearance of oral teeth is the alteration of multiple genetic pathways required for tooth development. The upper pharyngeal teeth are fully formed, but do not exhibit the ancestral relationship to other pharyngeal structures, suggesting that they would not be favored by selection. Our results illustrate an underlying commonality between constraint and selection as explanations for the irreversibility of trait loss; multiple genetic changes would be required to restore teeth themselves to the oral region and optimally functioning ones to the upper pharynx.Astyanax mexicanus | transgenic

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Section: Eda Overexpression Restores Teeth To the Upper Pharynx Of Thementioning

confidence: 99%

Selection and constraint underlie irreversibility of tooth loss in cypriniform fishes

Aigler

Jandzík

Hatta

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…At least in primates, the timing of tooth development could be modified at many checkpoints leading to full emergence, which is requisite by the time of weaning. Currently, sequence and timing of tooth primordium initiation, crown mineralization, and emergence are useful tools with which to reconstruct not only life history and phylogeny but also homology of tooth identities and embryonic tissues (Peterkova et al, 2006). Furthermore, variability in the timing of tooth germ formation may bear upon the likelihood that these teeth will develop at all in a given taxon (Luckett, 1993).…”

Section: Red In Tooth and Jawmentioning

confidence: 99%

Biological spacetime and the temporal integration of functional modules: A case study of dento–gnathic developmental timing

Boughner¹,

Hallgrímsson²

2007

Developmental Dynamics

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For the individual, coordination between tooth and jaw development is important to proper food acquisition and ingestion later in life. Among and within species, variation in dental and gnathic size, shape, and, in the case of teeth, number, must be mutually accommodating and functionally compatible. For these reasons, the development and evolution of these two systems should be closely integrated. Furthermore, the timing of dental development correlates tightly with life history events such as weaning. This correlation hints at a central regulation of the developmental timing of multiple systems that have tandem effects on physiology and behaviour. Important work on embryonic oral development continues to tease apart the molecular mechanisms that pattern jaw identity and establish tooth morphology and position in the alveolar bone. Still very poorly understood is what underlies rates and periods of gene activity such that pre-and postnatal tooth and jaw development are coordinated. Recent literature suggests at least some level of autonomy between permanent tooth and mandibular ontogenetic timing. However, whether the timing of these various signaling pathways is directly regulated or is an outcome of the pathways themselves is untested. Here, we review what is currently known about the embryonic signaling pathways that regulate tooth and jaw development in the context of time rather than space, as has been traditional. We hypothesize that the timing of mandibular and dental development is not directly mediated by a common factor but is an indirect outcome of strong selection for coordinated molecular pathways and growth trajectories. The mandible and lower jaw dentition is a powerful model with which to investigate the mechanisms that facilitate morphological change-in this case, the development and evolution-of organs that are closely integrated in terms of function, space and time. Developmental Dynamics 237:1-17, 2008.

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“…By studying genetic regulation of cusp morphogenesis in extant model organisms, we can understand the mechanisms that may underlie morphological changes during evolution. Previous studies have found that mutant mice can have severe abnormalities in tooth morphology (3)(4)(5)(6), and some authors have explored the evolutionary implications of tooth number modifications in mutants (7)(8)(9). However, to our knowledge, mutations in extant mouse or human samples that mimic morphologies of close ancestors have not been reported.…”

mentioning

confidence: 99%

Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition

Charles

Lazzari

Tafforeau

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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A central challenge in evolutionary biology is understanding how genetic mutations underlie morphological changes. Because highly calcified enamel enables preservation of detailed dental features, studying tooth morphology enables this question to be addressed in both extinct and extant species. Previous studies have found that mutant mice can have severe abnormalities in tooth morphology, and several authors have explored the evolutionary implications of tooth number modifications in mutants. However, although they can potentially shed much light on evolutionary mechanisms, anomalies in tooth shape remain poorly studied. Here, we report that alterations in dosage of the Fgf3 gene cause morphological changes in both genetically engineered mutant mice and in human patients. By comparing the dental morphologies in mice and humans carrying Fgf3 mutations with primitive rodent and primate fossils, we determined that decreases in dosage of Fgf3 lead to phenotypes that resemble the progressive reappearance of ancestral morphologies. We propose that modifications in the FGF signaling pathway have played an important role in evolution of mammalian dentition by giving rise to new cusps and interconnecting cusps by new crests. We anticipate that our multidisciplinary study will advance the detailed correlation of subtle dental modifications with genetic mutations in a variety of mammalian lineages. dental morphology ͉ Muroidea ͉ primates

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Phylogenetic memory of developing mammalian dentition

Cited by 96 publications

References 53 publications

Selection and constraint underlie irreversibility of tooth loss in cypriniform fishes

Selection and constraint underlie irreversibility of tooth loss in cypriniform fishes

Biological spacetime and the temporal integration of functional modules: A case study of dento–gnathic developmental timing

Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition

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