Phylogenetically related, clinically different: human papillomaviruses 6 and 11 variants distribution in genital warts and in laryngeal papillomatosis

Godinez, J.M.; Nicolás-Párraga, Sara; Pimenoff, Ville N.; Mengual‐Chuliá, Beatriz; Muñóz, Núbia; Bosch, F. Xavier; Sánchez, Gloria Inés; McCloskey, Jenny; Bravo, Ignacio G.

doi:10.1111/1469-0691.12420

Cited by 12 publications

(17 citation statements)

References 30 publications

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“…In addition, lineage A consisted of four sublineages, A1, A2, A3, and A4, with sublineages A3 and A4 being identified for the first time in this study. Due to the identification of a novel lineage B, originating from a single African isolate, the calculated maximum pairwise dissimilarly of the complete HPV11 genome variants (e.g., isolate LT4 versus isolate SA3408) reached 1.3%, exceeding the previously reported rate of diversity by approximately 4-fold (25,26,28). Hence, the genomic diversity of HPV11 of 1.3% is highly similar to that of its closest relative, HPV6 (1.6%) (29).…”

Section: Discussionmentioning

confidence: 72%

“…For the purpose of this study, a total of 207 HPV11 isolates were collected from 14 countries covering six continents, and four genomic regions, including the E5a, E5b, and L1 ORFs and the noncoding region URR were sequenced. These particular regions were selected for initial sequencing on the basis of findings from previous studies: (i) E5a, L1, and URR contain sequence information sufficient for unambiguous differentiation between HPV11 sublineages A1 and A2 (25,26,28); (ii) the E5a and E5b genes evolve faster and mutate more frequently than other HPV genes (40,41); and (iii) our recent genomic diversity study of HPV6 (the closest relative of HPV11) showed that the concatenated E5a-E5b-L1-URR sequence can be reliably used as a surrogate for the whole-genome phylogenetic clustering of HPV6 variants (29), and thus, sequencing of the same genomic regions would additionally allow comparison of the genetic diversity of a large number of HPV6 and HPV11 isolates. The genomes of a total of 30 HPV11 isolates showing the highest diversity in the E5a, E5b, L1, and/or URR genomic region were fully sequenced and phylogenetically evaluated together with 48 complete HPV11 genome sequences from GenBank and PaVE, of which 70.1% (34/48) mainly originated from two pre-FIG 1 HPV11 heat map and maximum likelihood trees inferred from 78 complete HPV11 genomes.…”

Section: Discussionmentioning

confidence: 99%

“…On the basis of the analysis of 32 complete HPV11 genomes originating mainly from Slovenia, HPV11 genomic variants were classified into two sublineages: sublineage A1 (previously termed the "prototypic variant") and sublineage A2 (previously termed the "nonprototypic variant"). Three additional HPV11 genomic diversity studies that focused on samples from the head and neck and the anogenital regions and that described the variability of the HPV11 genome from ethnogeographically closed cohorts and/or focused on individual complete or partial HPV11 genomic regions have recently been published (7,27,28). Several HPV11 genomic variants with highly similar nucleotide profiles were identified in these studies.…”

mentioning

confidence: 99%

“…Several HPV11 genomic variants with highly similar nucleotide profiles were identified in these studies. Apart from the observation that isolates from sublineage A2 prevail globally (7,28), no other ethnogeographical or clinical associations with HPV11 variants have been described to date (7,24,25,27,28).…”

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confidence: 99%

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Global Genomic Diversity of Human Papillomavirus 11 Based on 433 Isolates and 78 Complete Genome Sequences

Jelen

Chen

Kocjan

et al. 2016

J Virol

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Human papillomavirus 11 (HPV11) is an etiological agent of anogenital warts and laryngeal papillomas and is included in the 4-valent and 9-valent prophylactic HPV vaccines. We established the largest collection of globally circulating HPV11 isolates to date and examined the genomic diversity of 433 isolates and 78 complete genomes (CGs) from six continents. The genomic variation within the 2,800-bp E5a-E5b-L1-upstream regulatory region was initially studied in 181/207 (87.4%) HPV11 isolates collected for this study. Of these, the CGs of 30 HPV11 variants containing unique single nucleotide polymorphisms (SNPs), indels (insertions or deletions), or amino acid changes were fully sequenced. A maximum likelihood tree based on the global alignment of 78 HPV11 CGs (30 CGs from our study and 48 CGs from GenBank) revealed two HPV11 lineages (lineages A and B) and four sublineages (sublineages A1, A2, A3, and A4). HPV11 (sub)lineage-specific SNPs within the CG were identified, as well as the 208-bp representative region for CG-based phylogenetic clustering within the partial E2 open reading frame and noncoding region 2. Globally, sublineage A2 was the most prevalent, followed by sublineages A1, A3, and A4 and lineage B. IMPORTANCEThis collaborative international study defined the global heterogeneity of HPV11 and established the largest collection of globally circulating HPV11 genomic variants to date. Thirty novel complete HPV11 genomes were determined and submitted to the available sequence repositories. Global phylogenetic analysis revealed two HPV11 variant lineages and four sublineages. The HPV11 (sub)lineage-specific SNPs and the representative region identified within the partial genomic region E2/noncoding region 2 (NCR2) will enable the simpler identification and comparison of HPV11 variants worldwide. This study provides an important knowledge base for HPV11 for future studies in HPV epidemiology, evolution, pathogenicity, prevention, and molecular assay development. Human papillomavirus 11 (HPV11), which belongs to species 10 of the Alphapapillomavirus genus (Alpha-PV), is etiologically associated with approximately 20% of anogenital warts and 30 to 40% of laryngeal papillomas (1-11). HPV11 is generally considered a low-risk HPV type due to its rare presence in HPVrelated cancers in humans, especially cervical cancer (9). HPV11 is present in 0.5% of samples from HPV-positive women with a normal cytology worldwide and causes 2.3% of cervical low-grade squamous cell intraepithelial lesions (12, 13). However, rare case reports of HPV11-positive cases of cervical and anal squamous cell carcinomas, malignantly transformed laryngeal papillomas, and sinonasal inverted papillomas associated with squamous cell carcinoma can be found in the literature (14-21). Due to its clinical significance, HPV11 has been included in the current quadrivalent and nonavalent prophylactic HPV vaccines (22,23).The genetic diversity of HPV11 was studied for the first time in 1995, when Heinzel et al. sequenced the noncoding upstre...

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Global Genomic Diversity of Human Papillomavirus 11 Based on 433 Isolates and 78 Complete Genome Sequences

Jelen

Chen

Kocjan

et al. 2016

J Virol

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“…Samples were processed as previously described [11]. Briefly, total DNA was obtained by proteinase K incubation.…”

Section: Genotypingmentioning

confidence: 99%

Disagreement in high-grade/low-grade intraepithelial neoplasia and high-risk/low-risk HPV infection: clinical implications for anal cancer precursor lesions in HIV-positive and HIV-negative MSM

Pimenoff

Félez-Sánchez

Tous

et al. 2015

Clinical Microbiology and Infection

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Anal condylomata are common in HIV-positive individuals and among men who have sex with men (MSM). Generally attributable to infection by low-risk human papillomaviruses (HPVs), condylomata are considered benign low-grade squamous intraepithelial lesions (SILs). However, anal condylomata have occasionally been linked to high-grade SIL and to oncogenic, high-risk HPVs. Here we describe the range of intraepithelial lesions and of the associated HPVs in heterosexual men and women and MSM. Perianal and anal condylomata were collected from 243 patients (56 heterosexual women, 61 heterosexual men and 126 MSM, including 41 HIV-positive MSM). We assessed lesion histology and HPV genotype. Prevalence estimates and Poisson models were used. Irrespective of HIV infection status, MSM showed a higher proportion of condylomata as high-grade SILs compared to heterosexual men/women. High-grade SILs were also more prevalent in anal than in perianal lesions in all patient groups. HIV-positive MSM exhibited increased prevalence ratio (4.6; 95% confidence interval 2.1-10.0) of perianal low-grade SILs containing only high-risk HPVs compared to HIV-negative MSM. In addition, more than 64% of anal SILs with a high-grade component, regardless of HIV infection, were exclusively associated with low-risk HPVs. In anal condylomata, both high-grade and low-grade SILs can be associated with high-risk and/or low-risk HPVs. Particularly, low-grade perianal SILs associated with high-risk HPVs were common in HIV-positive MSM, while presence of only low-risk HPVs in high-grade SILs were common in both MSM groups. Our findings sound a note of caution for the common clinical practice for the treatment of anal condylomata as benign lesions in MSM and HIV-positive patients.

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Basaloid squamous cell carcinoma of the breast

Marco

Rubio

García

et al. 2020

Revista Española de Patología

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Phylogenetically related, clinically different: human papillomaviruses 6 and 11 variants distribution in genital warts and in laryngeal papillomatosis

Cited by 12 publications

References 30 publications

Global Genomic Diversity of Human Papillomavirus 11 Based on 433 Isolates and 78 Complete Genome Sequences

Global Genomic Diversity of Human Papillomavirus 11 Based on 433 Isolates and 78 Complete Genome Sequences

Disagreement in high-grade/low-grade intraepithelial neoplasia and high-risk/low-risk HPV infection: clinical implications for anal cancer precursor lesions in HIV-positive and HIV-negative MSM

Basaloid squamous cell carcinoma of the breast

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