Phylogeny and evolutionary genetics of porcine parvovirus in wild boars

Cadar, Dániel; Dán, Ádám; Tombácz, Kata; Lőrincz, Márta; Kiss, Tímea; Becskei, Zsolt; Spînu, Marina; Tuboly, Tamás; Cságola, Attila

doi:10.1016/j.meegid.2012.04.020

Cited by 44 publications

(45 citation statements)

References 56 publications

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“…PPV1 is the earliest known swine parvovirus of veterinary importance (Dunne et al, 1965). The virus is highly ubiquitous and has been found in swine herds of different categories including domestic and wild pigs, breading age females and boars, young piglets and fattening pigs (Dea et al, 1985;Duhamel et al, 1991;Lager and Mengeling, 1994;Drolet et al, 2002;Cadar et al, 2012;Truyen and Streck, 2012). It has also been discovered among pigs of different health statuses including vaccinated and non-vaccinated pigs, healthy and sick pigs (Jóźwik et al, 2009).…”

Section: Epidemiology Of Ppv1mentioning

confidence: 99%

Increasing diversity of swine parvoviruses and their epidemiology in African pigs

Afolabi

Iweriebor

Okoh

et al. 2019

Infection, Genetics and Evolution

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A B S T R A C TDetection of infectious viral agents has been on the increase globally with the advent and usage of more sensitive and selective novel molecular techniques in the epidemiological study of viral diseases of economic importance to the swine industry. The observation is not different for the pig-infecting member of the subfamily Parvovirinae in the family Parvoviridae as the application of novel molecular methods like metagenomics has brought about the detection of many other novel members of the group. Surprisingly, the list keeps increasing day by day with some of them possessing zoonotic potentials. In the last one decade, not less than ten novel swine-infecting viruses have been added to the subfamily, and ceaseless efforts have been in top gear to determine the occurrence and prevalence of the old and new swine parvoviruses in herds of pig-producing countries worldwide. The story, however, is on the contrary on the African continent as there is presently a dearth of information on surveillance initiatives of the viruses among swine herds of pig-producing countries in the region. Timely detection and characterization of the viral pathogens is highly imperative for the implementation of effective control and prevention of its spread. This review therefore presents a concise overview on the epidemiology of novel porcine parvoviruses globally and also provides up-to-date highlights on the reported cases of the viral agents in the African sub-region.

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Section: Epidemiology Of Ppv1mentioning

confidence: 99%

Increasing diversity of swine parvoviruses and their epidemiology in African pigs

Afolabi

Iweriebor

Okoh

et al. 2019

Infection, Genetics and Evolution

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“…They belong to the genus Parvovirus, subfamily Parvovirinae, family Parvoviridae and are among the major etiological agents of reproductive failure in sows. PPV infection of susceptible pregnant sows results in infection of the fetus, inducing reproductive complications characterized by embryonic and fetal death, mummifi cation, stillbirth and delayed return to estrus [8,9]. Porcine parvovirus (PPV) is a small, non -enveloped virus with a minus-polarity, single-stranded DNA genome.…”

Section: Introductionmentioning

confidence: 99%

Molecular Detection of Pseudorabies Virus (PrV), Porcine Parvovirus (PPV) and Porcine Circovirus 2 (PCV2) in Swine in Republic of Montenegro

et al. 2016

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The presence of pseudorabies virus (PrV), porcine parvovirus (PPV) and porcine circovirus 2 (PCV2) was examined in sixty samples (spleen and lymph nodes) and thirty samples of sacral ganglia collected from non-vaccinated swine by virus isolation and polymerase chain reaction (PCR). Using PCR method PrV was detected in three samples, PPV in seven samples and six samples were found positive for PCV2. The phylogenetic analysis of the nucleotide sequences of three PrV isolates identifi ed in this study showed high similarity and signifi cant clustering within the PrV genotype I strains such as Kaplan and Bartha isolated from pigs in Hungary, strain Becker isolated in USA and strain Kolchis isolated in Greece. The nucleotide sequences of two PPV isolates showed high level of similarity with the strain Challenge isolated from pigs in UK, strain Kresse isolated in USA and strains 77 and LZ isolated in China. The phylogenetic analysis of the nucleotide sequences of two PCV2 isolates showed high level of similarity and signifi cant clustering within genotype PCV2b strains such as NIVS-3, NIVS-5 and NIVS-6 isolated in Serbia, strain 3959 isolated in Austria, strain PM165 isolated from pigs in Brasil, and strain XT2008 isolated in China. The results of our study present the molecular characterization of PrV, PPV and PCV2 identifi ed in swine in Republic of Montenegro. Besides that, these results confi rmed that PCR is a very useful method for rapid detection of these viruses in subclinically infected swine.

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“…Thus, virus isolation proved to be less sensitive than PCR to demonstrate the presence of PPV genetic material in foetal tissues, or, in other words, PCR detected also non-infectious viral DNA besides the replicative forms of the virus. Based on the literature data [12][13][14][15] and on the presented serological and virus detecting results the following categories could be established in relation to protection level: i, full protection: seronegative and PCR negative foetuses (and no PPV excretion following challenge or infection, which parameter was not measured in this trial); ii, sufficient protection: seropositive and/or PCR positive, but virus isolation negative foetuses and no reduction in foetal numbers; and iii, insufficient protection: sero-, PCR-, and virus isolation positive foetuses and/or reduction of foetal numbers.…”

Section: Discussionmentioning

confidence: 99%

“…11 Based on experimental data with recent German field isolates of PPV-27a, PPV-143a, and two vaccine viruses (PPV-NADL-2 and PPV-IDT) it was concluded that PPV-27a cluster strains may influence effective vaccination against PPV. [12][13][14][15] The aim of this study was to compare the efficacy of Parvoruvax ® (PVX), an inactivated PPV (strain K22) and Erysipelothrix rhusiopathiae (serotype 2) bacterium-based vaccine, with a range of widely used commercial Parvo-Erysipelothrix vaccines (all containing genotype 1 PPV) against the effect of challenge of pregnant gilts with a PPV-27a type strain.…”

Section: Introductionmentioning

confidence: 99%

<p>Vaccine Protection Against Experimental Challenge Infection with a PPV-27a Genotype Virus in Pregnant Gilts</p>

Kiss

Kovács

Zádori

et al. 2020

VMRR

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Background/Introduction: Porcine parvovirus (PPV), the causative agent of severe reproductive failures in pigs, is present worldwide. The witnessed spread of the virulent 27a type PPV strains since its recognition raised concerns about the efficacy of the available commercial vaccines. Methods: To address this question, vaccinated pregnant gilts were challenged with a PPV-27alike virus strain and parameters related to vaccine efficacy were compared. Results: The K22 vaccine strain of Parvoruvax ® (PVX) was characterized as "Kresse-like" based on the epitope mapping data. Vaccination of the gilts induced a low level of antibody responses. Based on foetal mortality, the number of sows which had challenge virus-affected foetuses, the percent of PPV positive piglets/litters plus their PPV genome and viral load PVX outscored the other vaccinated groups. Conclusion: Stronger protection was provided by the "Kresse-like" K22 PPV strain-based vaccine than by the NADL-2 and NADL-like strain-based commercial vaccines against a PPV-27a cluster strain challenge. Vaccine-induced antibody levels as measured prechallenge were not found to be an accurate indicator of protection.

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Phylogeny and evolutionary genetics of porcine parvovirus in wild boars

Cited by 44 publications

References 56 publications

Increasing diversity of swine parvoviruses and their epidemiology in African pigs

Increasing diversity of swine parvoviruses and their epidemiology in African pigs

Molecular Detection of Pseudorabies Virus (PrV), Porcine Parvovirus (PPV) and Porcine Circovirus 2 (PCV2) in Swine in Republic of Montenegro

<p>Vaccine Protection Against Experimental Challenge Infection with a PPV-27a Genotype Virus in Pregnant Gilts</p>

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