Phylogeny, morphology and toxicity of benthic dinoflagellates of the genus Fukuyoa (Goniodomataceae, Dinophyceae) from a subtropical reef ecosystem in the South China Sea

Leung, Priscilla T.Y.; Yan, Meng; Lam, Veronica T.T.; Yiu, Sam King Fung; Chen, Chia‐Yun; Murray, J. Sam; Harwood, D. Tim; Rhodes, Lesley; Lam, Paul K.S.; Wai, Tak-Cheung

doi:10.1016/j.hal.2018.03.003

Cited by 29 publications

(18 citation statements)

References 39 publications

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“…Recently, two globular species of Gambierdiscus have been reclassified as Fukuyoa (F. yasumotoi and F. ruetzleri) and a new species described (F. paulensis) (Gomez et al, 2015). Both F. ruetzleri and F. paulensis produce toxins (Laza-Martinez et al, 2016;Rhodes and Smith, 2018;Leung et al, 2018).…”

Section: Occurrence Of Gambierdiscus Speciesmentioning

confidence: 99%

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Report of the Expert Meeting on Ciguatera Poisoning

2018

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The designations employed and the presentation of material in this information product do not imply the expression of any opinion whatsoever on the part of the Food and Agriculture Organization of the United Nations (FAO) or World Health Organization (WHO) concerning the legal or development status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or products of manufacturers, whether or not these have been patented, does not imply that these have been endorsed or recommended by FAO or WHO in preference to others of a similar nature that are not mentioned.The views expressed in this information product are those of the author(s) and do not necessarily reflect the views or policies of FAO or WHO.

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Section: Occurrence Of Gambierdiscus Speciesmentioning

confidence: 99%

“…no MBA or RBA data available no information available lethal to brine shrimp (Leung et al, 2018) no CTXs (Leung et al, 2018) no MTX1 (Leung et al, 2018) (Leung et al, 2018) N2a+ (Litaker et al, 2017) haemolytic activity (Holland et al, 2013)…”

Section: F Ruetzlerimentioning

confidence: 99%

Report of the Expert Meeting on Ciguatera Poisoning

2018

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“… 17,21–24 The first description of MTX3 dates back to 1994 16 . Since then, liquid chromatography/tandem mass spectrometry (LC/MS/MS) analyses have revealed the presence of putative MTX3 in several Gambierdiscus and Fukuyoa species 17,21–37 . The molecular structure of this compound was recently elucidated in two concurrent articles, after isolation from both G. australes 38 and G. belizeanus.…”

Section: Introductionmentioning

confidence: 99%

Characterization of maitotoxin‐4 (MTX4) using electrospray positive mode ionization high‐resolution mass spectrometry and UV spectroscopy

Pisapia

Sibat

Watanabe

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale The dinoflagellate genera Gambierdiscus and Fukuyoa are producers of toxins responsible for Ciguatera Poisoning (CP). Although having very low oral potency, maitotoxins (MTXs) are very toxic following intraperitoneal injection and feeding studies have shown they may accumulate in fish muscle. To date, six MTX congeners have been described but two congeners (MTX2 and MTX4) have not yet been structurally elucidated. The aim of the present study was to further characterize MTX4. Methods Chemical analysis was performed using liquid chromatography coupled to a diode‐array detector (DAD) and positive ion mode high‐resolution mass spectrometry (LC/HRMS) on partially purified extracts of G. excentricus (strain VGO792). HRMS/MS studies were also carried out to tentatively explain the fragmentation pathways of MTX and MTX4. Results The comparison of UV and HRMS (ESI+) spectra between MTX and MTX4 led us to propose the elemental formula of MTX4 (C157H241NO68S2, as the unsalted molecule). The comparison of the theoretical and measured m/z values of the doubly charged ions of the isotopic profile in ESI+ were coherent with the proposed elemental formula of MTX4. The study of HRMS/MS spectra on the tri‐ammoniated adduct ([M – H + 3NH4]2+) of both molecules gave additional information about structural features. The cleavage observed, probably located at C99–C100 in both MTX and MTX4, highlighted the same A‐side product ion shared by the two molecules. Conclusions All these investigations on the characterization of MTX4 contribute to highlighting that MTX4 belongs to the same structural family of MTXs. However, to accomplish a complete structural elucidation of MTX4, an NMR‐based study and LC/HRMSn investigation will have to be carried out.

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“…(b) Chemical structure of maitotoxin-1 (MTX-1: adapted from Murata et al 1993 [71]. [85] i.p: intraperitoneal injection; MBA: mouse bioassay; RBA: receptor binding assay; N2a: neuro-2 mouse neuroblastoma assay; CTX: ciguatoxin; MTX: maitotoxin; 44-MG: 44-methylgambierone; *: toxins asterisked were not produced by all strains of these species. † Gambierdiscus toxicus was reclassified in 2009 by Litaker et al [36], therefore toxins published from this species may differ from that reported prior to that time.…”

Section: Ciguatera Fish Poisoning Related Toxins and Their Toxicitymentioning

confidence: 99%

Ciguatera Fish Poisoning: The Risk from an Aotearoa/New Zealand Perspective

Rhodes

Smith

Murray

et al. 2020

Toxins

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Gambierdiscus and Fukuyoa species have been identified in Aotearoa/New Zealand’s coastal waters and G. polynesiensis, a known producer of ciguatoxins, has been isolated from Rangitāhua/Kermadec Islands (a New Zealand territory). The warming of the Tasman Sea and the waters around New Zealand’s northern subtropical coastline heighten the risk of Gambierdiscus proliferating in New Zealand. If this occurs, the risk of ciguatera fish poisoning due to consumption of locally caught fish will increase. Research, including the development and testing of sampling methods, molecular assays, and chemical and toxicity tests, will continue. Reliable monitoring strategies are important to manage and mitigate the risk posed by this emerging threat. The research approaches that have been made, many of which will continue, are summarised in this review.

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Phylogeny, morphology and toxicity of benthic dinoflagellates of the genus Fukuyoa (Goniodomataceae, Dinophyceae) from a subtropical reef ecosystem in the South China Sea

Cited by 29 publications

References 39 publications

Report of the Expert Meeting on Ciguatera Poisoning

Report of the Expert Meeting on Ciguatera Poisoning

Characterization of maitotoxin‐4 (MTX4) using electrospray positive mode ionization high‐resolution mass spectrometry and UV spectroscopy

Ciguatera Fish Poisoning: The Risk from an Aotearoa/New Zealand Perspective

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