This study aimed to explore the interconnections among quality-of-life, sleep quality, and academic self-efficacy as loads of researches have indicated a correlation between these elements, suggesting that they are intricately linked. The current investigation delved into the reciprocal relationships between these concepts, examining their bidirectional correlations with 410 students (Female = 267, Male = 143), (M = 22.04, SD = 3.367), and the findings indicated an interrelationship among the quality-of-life, academic self-efficacy, and sleep quality of university students. The results of the study revealed a continuous positive significant relationship between all sub-categories of the quality of life and academic self-efficacy (r = .396, p < .01) which is a novel result in the field. Another novel result is that decreasing sleep quality is associated with low academic self-efficacy (r=-.121, p < .01). Studies in the field were supported with this study in terms of revealing the existing correlation between quality of life and sleep quality measured with Richards – Campbell Sleep Scale (r = .341, p < .01) and Pittsburgh Sleep Quality Index (r = .439, p < .01) both of which indicate a relationship between an increasing sleep quality and high quality of life. On the other hand, the quality of life and sleep quality are found to be significant predictors of academic self-efficacy which is an important contributing result to the field (R2 = 0.226, p < .0,01), (R2 = 0.015, p < .0,05). These results must be taken into account when the role of sleep quality and quality-of-life on academic life of individuals is researched.