Physical activity alters antioxidant status in exercising elderly subjects

Rousseau, Anne-Sophie; Margaritis, Irène; Arnaud, Josiane; Faure, Henri; Roussel, Anne‐Marie

doi:10.1016/j.jnutbio.2005.10.001

Cited by 51 publications

(43 citation statements)

References 42 publications

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“…The elderly population is particularly at risk of developing clinical complications related to low vitamin D levels, as their ability to generate the precursor of vitamin D in the skin is reduced with the advancement of age, which is further aggravated by the change in lifestyle that reduces outdoor physical activities and by immobility [13][14][15][16]. Moreover, the messages and widely spread information of adverse effect of chronic unprotected sunlight exposure, at times, lead to overprotection, either by avoiding sunlight or by using sun protective agents to reduce exposure, which further contribute to inadequate vitamin D levels.…”

Section: Hypovitaminosis D and Agingmentioning

confidence: 99%

Vitamin D and aging: old concepts and new insights

Lanske

Razzaque

2007

The Journal of Nutritional Biochemistry

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Aging is a complex biological process driven by a selective class of molecules and pathways that affect overall deterioration of physiological functions to increase the risk of age-related diseases. A role of vitamin D in mammalian aging is well documented. Since vitamin D has an essential role in bone formation and mineralization, its deficiency results in impaired bone mineralization, such as rickets in children, osteomalacia in adults and osteoporosis in the aged population. Vitamin D replacement therapy therefore is one of the most commonly prescribed treatments for the elderly. Recent studies using genetically altered mouse models, such as in Fgf-23 −/− and klotho mutant mice, that exhibit altered mineral ion metabolism due to high vitamin D activities showed features of premature aging that include atherosclerosis, emphysema, osteopenia/osteoporosis, hypogonadism, soft tissue calcifications and generalized atrophy of organs; the pathologic effects of vitamin D in these mouse models are obvious, as diminution or genetic ablation of the vitamin D pathway ameliorated most of the above-mentioned phenotypes, by reversing mineral ion metabolism, and the resultant effect being prolonged survival of the mutant mice. These in vivo mouse studies, although subject to further molecular characterization, add new insights into the role of vitamin D in aging.

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Section: Hypovitaminosis D and Agingmentioning

confidence: 99%

Vitamin D and aging: old concepts and new insights

Lanske

Razzaque

2007

The Journal of Nutritional Biochemistry

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“…These ROS may cause cellular damage that may subsequently lead to lipid oxidation, protein denaturation or DNA damage (Droge, 2002). However, exercise is also reported to enhance the endogenous antioxidant defences (Rousseau et al, 2006). For example, repeated episodes of aerobic exercise has been reported to induce the expression of antioxidant enzymes (Ji, 2002), and several studies have shown a relationship between extent of physical activity and plasma antioxidant concentrations (Dekany et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Altered Antioxidant and Trace-Element Status in Adolescent Female Gymnasts

Al-Shammari¹,

Shafi²,

Nurmi-Lawton³

et al. 2010

International Journal of Sport Nutrition and Exercise Metabolism

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High levels of physical activity have been linked to benefits in cardiovascular and bone health by affecting, in part, changes in proinflammatory profile. Therefore, we have aimed to assess the effects of intensive training on markers of inflammation, endothelial activation and auto-immunity in the absence of the potential confounding effects of incident atherosclerosis. The subjects comprised 25 competitive gymnasts and 19 healthy sedentary adolescent females, aged 8-17 years. Serum soluble intercellular adhesion molecule 1 (sICAM-1), high sensitivity C-reactive protein (hsCRP), heat shock protein 27 (Hsp27) and Hsp27 antibody titres were measured by ELISAs in a sample of adolescent girls who were either physically active (competitive gymnasts) or sedentary. The association between age, body mass index (BMI), dietary intake, serum hsCRP, sICAM-1 and Hsp27 antigen and antibody titres were determined. The mean serum sICAM-1 concentrations were significantly higher in the gymnasts compared to the sedentary females (0.29 ± 0.02 versus 0.23 ± 0.01 mg·L -1 , p < 0.01). In contrast serum hsCRP concentrations were substantially lower in the gymnasts compared to the sedentary adolescent females (0.49 ± 0.03 versus 1.38 ± 0.19 mg·L -1 , p < 0.001). Differences remained significant after adjustment for anthropometric factors. We also found that serum Hsp27 antigen concentrations were determined by dietary saturated fat intake (p < 0.001), and antibody titres to Hsp27 were determined by dietary PUFA (p < 0.001) after adjustment for BMI. Our findings show that young female gymnasts have an altered profile of inflammatory markers and endothelial activation compared to their less physically active peers.

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“…The extent of oxidative stress is dependent on several factors, including age, oxygen consumption, antioxidant levels, and the presence of adequate repair systems [11]. Although regular exercise training is effective to enhance adaptive responses thereby diminishing oxidative stress in younger individuals [12][13][14], it appears that aging may partly attenuate these adaptations [15,16]. It thus has been proposed that elders who exercise have greater requirements for dietary antioxidant [17] such as vitamins C and E [18].…”

Section: Introductionmentioning

confidence: 99%