Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system

Santulli, Gaetano; Ciccarelli, Michele; Trimarco, Bruno; Iaccarino, Guido

doi:10.3389/fphys.2013.00209

Cited by 76 publications

(70 citation statements)

References 92 publications

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“…Age distribution in our study was comparable with the home BP study by Niiranen et al, [13] but when compared with the population in a larger crosssectional BP study by Varis et al, [2], the present material was somewhat younger. This increases the validity of the present doi: 10.7243/2054-7161-1-1 paper as among the elderly physical activity or its absence affects the factors behind elevated BP [16].…”

Section: Discussionsupporting

confidence: 59%

Experience improves economical compliance of home blood pressure monitoring

Varis¹,

Kantola²

2014

Clin Nephrol Urol Sci

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Background: Home blood pressure monitoring (HBPM) is a valid way of assessing blood pressure. It has been shown to reduce antihypertensive treatment cost and the number of drugs needed. However, the proper economical commitment of the patients has not been clarified. Methods: From a pool of 40000 Finns a sample of one thousand hypertensive people who had access to e-mail and who had performed HBPM was randomly selected. Their opinion about an acceptable price for a HBPM device was asked by using an electronic questionnaire. Altogether 640 people answered the questionnaire. Results: Majority of the study patients without own experience of HBPM considered 60 € as an upper level for HBPM device. Nearly 40% saw 30 € as a maximum price for a HBPM device. Among patients who own a HBPM device the situation was different. Quite few valuated the HBPM devices below 30 €. The price level of 61-90 € was the most acceptable. Family income level did not play any major role in the valuation of HBPM devices. Conclusion:The financial BP home measurement compliance of the patients without own HBPM device was low. Main reason for the measurement undervaluation is probably the low appreciationm of the concept of measuring BP at home. On the contrary, patients who had already a HBPM device and hence experience of its influence on the BP treatment had a tendency to pay higher prices for the device. As HBPM has been shown to decrease the cost of hypertension treatment the reimbursement of HBPM devices should be considered as already antihypertensive treatment is reimbursed.

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Section: Discussionsupporting

confidence: 59%

Experience improves economical compliance of home blood pressure monitoring

Varis¹,

Kantola²

2014

Clin Nephrol Urol Sci

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“…Not only do our results have substantial translational implications for the development of novel therapeutic strategies, such as mitochondria-targeted antioxidants for treatment of mitochondrial myopathies, ROS mediated muscular dysfunctions and other healthspan limiting disorders (12,42), we also present a molecular mechanism for age-dependent skeletal muscle weakness and regulation of musculoskeletal force generation.…”

Section: Discussionmentioning

confidence: 85%

“…Mitochondria are a major source of cellular ROS (7,9) and have been proposed to play a key role in age-dependent loss of skeletal muscle function (3,7,10), likely through the production of oxidative damage (11,12). However, the molecular mechanisms underlying this process have not been fully determined.…”

mentioning

confidence: 99%

Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging

Umanskaya

Santulli

Xie

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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138

144

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Age-related skeletal muscle dysfunction is a leading cause of morbidity that affects up to half the population aged 80 or greater. Here we tested the effects of increased mitochondrial antioxidant activity on age-dependent skeletal muscle dysfunction using transgenic mice with targeted overexpression of the human catalase gene to mitochondria (MCat mice). Aged MCat mice exhibited improved voluntary exercise, increased skeletal muscle specific force and tetanic Ca 2+ transients, decreased intracellular Ca 2+ leak and increased sarcoplasmic reticulum (SR) Ca 2+ load compared with age-matched wild type (WT) littermates. Furthermore, ryanodine receptor 1 (the sarcoplasmic reticulum Ca 2+ release channel required for skeletal muscle contraction; RyR1) from aged MCat mice was less oxidized, depleted of the channel stabilizing subunit, calstabin1, and displayed increased single channel open probability (P o ). Overall, these data indicate a direct role for mitochondrial free radicals in promoting the pathological intracellular Ca 2+ leak that underlies age-dependent loss of skeletal muscle function. This study harbors implications for the development of novel therapeutic strategies, including mitochondria-targeted antioxidants for treatment of mitochondrial myopathies and other healthspan-limiting disorders.aging | skeletal muscle | exercise capacity | muscle weakness | oxidation

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“…The prevalence of HF has increased along with the aging of the general population [3] and because of improved survival after acute myocardial infarction [4,5] . Indeed, a better understanding of the pathophysiology and medical management of myocardial infarction means that such patients are living longer with damaged hearts, and many of them go on to develop HF [5,6] .…”

Section: Introductionmentioning

confidence: 99%