Physical Activity and Benign Prostatic Hyperplasia

Platz, Elizabeth A.; Kawachi, Ichiro; Rimm, Eric B.; Colditz, Graham A.; Stampfer, Meir J.; Willett, Walter C.; Giovannucci, Edward

doi:10.1001/archinte.158.21.2349

Cited by 133 publications

(78 citation statements)

References 33 publications

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“…[8][9][10][11] Inverse association emerged for both occupational and recreational PA and was consistently found in different strata of selected covariates. The strongest association emerged with occupational or recreational PA in young adulthood (~50% of risk reduction), but some protection was also found for high PA levels at ages 50-59 years (one-third reduction).…”

Section: Discussionmentioning

confidence: 83%

“…24 An alternative hypothesis suggested that sedentary lifestyle decreases the sympathetic nervous system activity, which is associated with increased prostate smooth muscle tone and severity of lower urinary tract symptoms. 11 As urological complications of BPH may lead to mobility reduction and may discourage recreational activities, an inverse causation cannot be totally ruled out. 25 However, a remarkable consistency emerged in the direction and strength of the associa- A possible weakness of the present study is the lack of a wellaccepted definition of BPH.…”

Section: Discussionmentioning

confidence: 99%

“…19 Different methods were used in different studies, considering the relation between PA and BPH, [8][9][10][11] which may, at least in part, be responsible of inconsistencies of results. In cohort studies including repeated measures of PA, however, recall of PA level in the past proved to be reliable.…”

Section: Discussionmentioning

confidence: 99%

“…In the ''Massachusetts Male Aging'' prospective study (198 cases), 10 an inverse association emerged between BPH and total PA at enrollment (median 9 years before diagnosis). The Health Professional follow-up study, including 3,743 cases, 11 showed that risk of BPH decreased linearly with the increase of recreational PA, and that walking had a particularly beneficial effect.…”

mentioning

confidence: 99%

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Lifetime occupational and recreational physical activity and risk of benign prostatic hyperplasia

Maso

Zucchetto

Tavani

et al. 2006

Intl Journal of Cancer

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To investigate the relation between occupational and recreational physical activity (PA) in different periods of life and the risk of benign prostatic hyperplasia (BPH), we conducted a hospital-based, case-control study in Italy. The study included 1,369 histologically confirmed BPH and 1,451 controls, admitted to the same hospitals for acute, nonneoplastic diseases. Odds ratios (ORs) and 95% confidence intervals (CIs) of BPH, according to lifetime PA, were obtained by unconditional multiple logistic regression models, including terms for age, study center and education. Compared to the lowest level of occupational PA, the multivariate ORs for BPH for the heavy/strenuous level were 0.6 (95% CI, 0.4-0.8) at age 15-19, 0.6 (95% CI, 0.4-0.8) at age 30-39 and 0.7 (95% CI, 0.5-0.9) at age 50-59. Moreover, compared to <2 hr/week of recreational PA, the ORs for BPH for the highest level ( 5 hr/week) were 0.5 (95% CI, 0.4-0.7) at age 15-19, 0.6 (95% CI, 0.5-0.8) at age 30-39, and 0.7 (95% CI, 0.5-0.8) at age 50-59. All inverse trends in risk were significant, and no heterogeneity was found by reason of BPH-diagnosis, age at diagnosis, and body mass index (BMI). The inverse association between PA and BPH risk may be due to favorable hormonal correlates of PA, but residual confounding by socioeconomic covariates cannot be excluded. A moderate PA at any ages may help reducing a sizeable number of BPH. ' 2005 Wiley-Liss, Inc.Key words: physical activity; benign prostatic hyperplasia; casecontrol study Benign prostatic hyperplasia (BPH) is a condition relatively frequent in men aged 60 or above. BPH can cause prostate enlargement, lower urinary tract symptoms and serious medical complications (e.g. urinary obstruction, renal failure, etc.). 1 Although a growing epidemiological evidence suggests that genetic characteristics and lifestyle factors related to levels of androgens and estrogens are associated to BPH, 2 relatively few epidemiological studies have been conducted on potentially modifiable risk factors such as diet, alcohol consumption, and obesity. [2][3][4][5][6][7] In particular, the relation between physical activity (PA) and BPH risk has been investigated in few epidemiological studies. One case-control study was conducted in a low-risk population (China), including 206 BPH cases, 8 to assess energy expenditure for occupational and recreational PA at different ages. This study did not suggest an association between PA and BPH.Three cohort studies have also evaluated data on the topic. The Physicians' Health Study, based on 320 cases, 9 included only information on leisure-time exercise and showed inconsistent inverse associations between BPH and PA across strata of exercise. In the ''Massachusetts Male Aging'' prospective study (198 cases), 10 an inverse association emerged between BPH and total PA at enrollment (median 9 years before diagnosis). The Health Professional follow-up study, including 3,743 cases, 11 showed that risk of BPH decreased linearly with the increase of recreational PA, and that walking had...

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Lifetime occupational and recreational physical activity and risk of benign prostatic hyperplasia

Maso

Zucchetto

Tavani

et al. 2006

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…5,6 Similar report by steve A. Kaplan showed that a few things may cause lower urinary tract symptoms which could be urologic and non urologic states; mediators that increases obstructive urinary symptoms, obesity, regular alcohol consumption, and elevated blood pressure all could lead to benign prostatic hyperplasia. 7,8 This is supported too in Aruna v. sarma et al studies were they alluded that black 9 , obesity 10 ,diabetes mellitus 11 ,high levels of alcohol consumption 12 and physical inactivity 13 increases risk of BPH development. The obstructive symptoms includes the urinary hesistancy, delay in initiating micturition, intermittency, involuntary interruption of voiding, weak urinary stream, straining to void, a sensation of incomplete emptying, and terminal dribbling.…”

Section: Imentioning

confidence: 87%