Physical Activity and Benign Prostatic Hyperplasia-Related Outcomes and Nocturia

Wolin, Kathleen Y.; Grubb, Robert L.; Pakpahan, Ratna; Ragard, Lawrence R.; Mabie, Jerome; Andriole, Gerald L.; Sutcliffe, Siobhan

doi:10.1249/mss.0000000000000444

Cited by 26 publications

(33 citation statements)

References 39 publications

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“…[3,12,15,33] Men who are physically active are at lower risk of nocturia, the most common and bothersome of LUTS. [34] Indeed, a meta-analysis of 11 published studies with over 43,000 men found that moderate to vigorous physical activity reduced the risk of LUTS by as much as 25% compared to a sedentary lifestyle, with stronger effects seen with higher levels of activity. [35] In addition, a greater physical activity at baseline predicted improvement in LUTS symptoms in a 5 year prospective study of 780 men, aged 35 to 80 at baseline.…”

Section: Methodsmentioning

confidence: 99%

Lifestyle and lower urinary tract symptoms

Lin¹,

Freedland²

2015

Current Opinion in Urology

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Purpose of review the primary purpose of this review is to provide an overview of the current evidence linking lifestyle factors and lower urinary tract symptoms (LUTS), and their relevance in men. An extensive literature search from January 2013 to August 2014 was conducted, reviewed and summarized in conjunction with key prior evidence. Recent findings The main findings from this review include: 1) Epidemiological data repeatedly show a favorable relationship between a healthy eating habits and regular physical activity level and a lower risk for LUTS or progression of LUTS, 2) certain specific nutrients or dietary factors may contribute to the link between diet and LUTS due to their anti-inflammatory potential, and 3) very little research has been conducted to test the epidemiological findings in randomized controlled trials. Summary Rigorously designed clinical trials are needed to confirm the association between lifestyle factors and LUTS and the effect of lifestyle modification on the development or progression of LUTS. Nevertheless, a healthy lifestyle is known to closely relate with chronic diseases like cardiovascular disease and diabetes. Thus, promoting a healthy lifestyle with good quality diet and regular physical activity is beneficial not only for potentially improving or reducing LUTS but also for cardiovascular and overall health. Clinicians are encouraged to include healthy lifestyle counseling in their routine care for patients with LUTS.

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Section: Methodsmentioning

confidence: 99%

Lifestyle and lower urinary tract symptoms

Lin¹,

Freedland²

2015

Current Opinion in Urology

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“…Benign prostatic hyperplasia (BPH) is the most common pathologic and clinical abnormality associated with the prostate. It is estimated that histologic BPH lesions are encountered in men as young as in their 20s and 30s and the disease continues to rise as they age [Wolin et al, ]. Epidemiological data indicate that asymptomatic BPH affects 50% of all men by the time they turn 50 and escalates to >90% in men 85 years or older [Oesterling, ].…”

Section: The Integrated Modelmentioning

confidence: 99%

Disorder, Promiscuous Interactions, and Stochasticity Regulate State Switching in the Unstable Prostate

Kulkarni

Getzenberg

2016

J of Cellular Biochemistry

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A causal link between benign prostatic hyperplasia (BPH) and prostate cancer has long been suspected but not widely accepted. A new model is proposed that supports such a connection. In contrast to the prevailing wisdom, our model, that draws on dynamical systems theory, suggests that in response to stress, epithelial cells in the unstable gland can give rise to both types of diseases via a phenotypic switching mechanism. The central idea is that phenotypic switching is a stochastic process which exploits the plasticity of the epithelial cell. It is driven by 'noise' contributed by the conformational dynamics of proteins that are intrinsically disordered. In a system that is noisy when stressed, disorder promotes promiscuity, unmasks latent information, and rewires the network to cause phenotypic switching. Cells with newly acquired phenotypes can transcend the traditional zonal boundaries to give rise to BPH or prostate cancer depending on the microenvironment. Establishing causality between the two diseases may provide us with an opportunity to better understand their etiology and guide prevention and treatment strategies. J. Cell. Biochem. 117: 2235-2240, 2016. © 2016 Wiley Periodicals, Inc.

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“…BPH is the most common pathologic and clinical abnormality associated with the prostate gland. Indeed, histologic BPH lesions are encountered in men as young as in their 20s and 30s and the prevalence of the disease continues to rise as they age [ 26 ]. Although accurate estimates like those available for PCa are not available for BPH, epidemiological data indicate that asymptomatic BPH affects 50% of all men by the time they turn 50, and escalates to >90% in men 85 years or older [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target

Salgia

Jolly

Dorff

et al. 2018

JCM

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Prostate cancer (PCa) is a leading cause of mortality and morbidity globally. While genomic alterations have been identified in PCa, in contrast to some other cancers, use of such information to personalize treatment is still in its infancy. Here, we discuss how PAGE4, a protein which appears to act both as an oncogenic factor as well as a metastasis suppressor, is a novel therapeutic target for PCa. Inhibiting PAGE4 may be a viable strategy for low-risk PCa where it is highly upregulated. Conversely, PAGE4 expression is downregulated in metastatic PCa and, therefore, reinstituting its sustained expression may be a promising option to subvert or attenuate androgen-resistant PCa. Thus, fine-tuning the levels of PAGE4 may represent a novel approach for personalized medicine in PCa.

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Physical Activity and Benign Prostatic Hyperplasia-Related Outcomes and Nocturia

Abstract: Supplemental digital content is available in the text.

Cited by 26 publications

References 39 publications

Lifestyle and lower urinary tract symptoms

Lifestyle and lower urinary tract symptoms

Disorder, Promiscuous Interactions, and Stochasticity Regulate State Switching in the Unstable Prostate

Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target

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