Physical activity and biomarkers in breast cancer survivors: A systematic review

Löf, Marie; Bergström, Katrin; Weiderpass, Elisabete

doi:10.1016/j.maturitas.2012.07.002

Cited by 52 publications

(31 citation statements)

References 36 publications

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“…Similar conclusions have been reported in previous experimental studies [15, 26, 28]. Moreover, it is important to highlight that this is the first meta-analysis that has summarized the effectiveness of exercise training in modulating the IGF system in breast cancer survivors because a previous systematic review regarding exercise and blood biomarkers in breast cancer survivors was published by Löf and colleagues [19], but the authors did not undertake data synthesis analysis.…”

Section: Discussionsupporting

confidence: 81%

“…The reference lists from retrieved articles were checked to identify additional titles. The authors also examined data from previous reviews published by Ballard-Barbash et al [18] and Löf and colleagues [19]. Moreover, two authors (MI and RR-V) searched for other relevant trials listed in journals that specialized in oncology (e.g., BMC Cancer , Breast Cancer Research, Cancer , Cancer Epidemiology, Biomarkers & Prevention, Journal of Clinical Oncology , Journal of Oncology Practice and The Lancet Oncology ).…”

Section: Methodsmentioning

confidence: 99%

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The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis

et al. 2016

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BackgroundInsulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancer-related outcomes and survival, although its effects on IGF´s are not well understood. This meta-analysis aimed to determine the effects of exercise in modulating IGF´s system in breast cancer survivors.MethodsDatabases of PuMed, EMBASE, Cochrane Central Register of Controlled Trials, EMBASE, ClinicalTrials.gov, SPORTDiscus, LILACS and Scopus were systematically searched up to November 2014. Effect estimates were calculated through a random-effects model of meta-analysis according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I2 test. Risk of bias and methodological quality were evaluated using the PEDro score.ResultsFive randomized controlled trials (n = 235) were included. Most women were post-menopausal. High-quality and low risk of bias were found (mean PEDro score = 6.2 ± 1). Exercise resulted in significant improvements on IGF-I, IGF-II, IGFBP-I, IGFBP-3, Insulin and Insulin resistance (P < 0.05). Non-significant differences were found for Glucose. Aerobic exercise improved IGF-I, IGFBP-3 and Insulin. No evidence of publication bias was detected by Egger´s test (p = 0.12).ConclusionsExercise improved IGF´s in breast cancer survivors. These findings provide novel insight regarding the molecular effects of exercise on tumoral microenvironment, apoptosis and survival in breast cancer survivors.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-016-2733-z) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 81%

Section: Methodsmentioning

confidence: 99%

The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis

et al. 2016

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“…It can reduce visceral adiposity (Donnelly et al, 2009), which is associated with increased risk of breast cancer in postmenopausal women (Goodwin et al, 2011). Although, various researchers reported exercise interventions implemented concurrent with breast cancer treatment can cause increase in cardiovascular fitness, muscular strength, and body composition and decrease in cancer-related fatigue (Löf et al, 2012), water-based exercise is an ideal form of exercise for obese patients and may provide an attractive alternative to land-based exercise for achieving improved health and fitness in these populations (Takeshima et al, 2002;Meredith-Jones et al, 2011).…”

Section: Change In Adiponectin and Oxidative Stress After Modifiable mentioning

confidence: 99%

Change in Adiponectin and Oxidative Stress after Modifiable Lifestyle Interventions in Breast Cancer Cases

Karimi

Roshan²

2013

Asian Pacific Journal of Cancer Prevention

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Background: Breast cancer is one of the most frequent diseases in women today. Little information exists on modifiable lifestyle factors including effects of ginger supplements (as an anti-oxidant and anti-inflammatory herbal) and water-based exercise on biomarkers related to oxidative stress such as malondialdehyde (MDA), nitric oxide (NO) and glutathione peroxidase (GPx) and adiponectin in obese women with breast cancer. The aim of this study was to determine the single and concomitant effect of 6-wks water-based exercise and oral ginger supplement on the aforesaid markers in obese women with breast cancer. Materials and Methods: Forty women diagnosed with breast cancer (48±5.4 years, 76±9 kg, fat mass 41.8±4%), volunteered to participate in the study. Subjects were randomly assigned into four groups; placebo, water-based exercise, ginger supplement and water-based exercise+ginger supplement groups. Subjects in the ginger supplement group and the water-based exercise+ginger supplement group orally received 4 capsules (each capsule contained 750 mg), 7 days a week for 6 weeks. The water-based exercise program featured progressive increase in intensity and time, ranging from 50% to 75% of heart rate reserve, in a pool with 15 meters width, 4 times a week for 6 weeks. Fasting blood samples were collected at pre-test and post-test time points. Results: The ginger supplementation and or the water-base exercise resulted in an increase of adiponectin, NO and GPx and reduction MDA, as compared to pre-test values. However, the combined intervention (water-base exercise and ginger supplement) group showed significantly a far better effect on the biomarkers related to oxidative stress and adiponectin levels, as compared to the waterbase exercise or ginger supplement alone groups and the age-matched placebo group. Conclusions: Our results revealed that water-base exercise is a non-drug therapeutic strategy to reduce systemic stress in obese women suffering from breast cancer. Further, ginger supplementation alone or in combination with training, also play an important role in the pathogenesis of oxidative stress in obese women diagnosed with breast cancer.

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“…KDE is a method for smoothing point patterns into a generalized surface by applying a kernel function with specified search radius to each point in the data set, and is commonly utilized for GPS data in human and animal studies [36–38]. We hypothesize that increased exposure to walkable and recreation environments will be associated with reduced insulin resistance, mediated through the pathway of physical activity [39, 40]. Furthermore, we hypothesize that a dynamic GPS-based exposure measure using KDE will be better able to establish this association than a traditional, home-based static measure of exposure.…”

Section: Introductionmentioning

confidence: 99%

Kernel Density Estimation as a Measure of Environmental Exposure Related to Insulin Resistance in Breast Cancer Survivors

Jankowska

Godbole

Meseck

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Environmental factors may influence breast cancer, however most studies have measured environmental exposure in neighborhoods around home residences (static exposure). We hypothesize that tracking environmental exposures over time and space (dynamic exposure) is key to assessing total exposure. This study compares breast cancer survivors' exposure to walkable and recreation-promoting environments using dynamic Global Positioning System (GPS) and static home-based measures of exposure in relation to insulin resistance. Methods GPS data from 249 breast cancer survivors living in San Diego County were collected for one week along with fasting blood draw. Exposure to recreation spaces and walkability was measured for each woman's home address within an 800m buffer (static), and using a kernel density weight of GPS tracks (dynamic). Participants' exposure estimates were related to insulin resistance (using the homeostatic model assessment of insulin resistance, HOMA-IR) controlled by age and BMI in linear regression models. Results The dynamic measurement method resulted in greater variability in built environment exposure values than did the static method. Regression results showed no association between HOMA-IR and home-based, static measures of walkability and recreation area exposure. GPS-based dynamic measures of both walkability and recreation area were significantly associated with lower HOMA-IR (p<0.05). Conclusions Dynamic exposure measurements may provide important evidence for community- and individual-level interventions that can address cancer risk inequities arising from environments wherein breast cancer survivors live and engage. Impact This is the first study to compare associations of dynamic versus static built environment exposure measures with insulin outcomes in breast cancer survivors.

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Physical activity and biomarkers in breast cancer survivors: A systematic review

Cited by 52 publications

References 36 publications

The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis

The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis

Change in Adiponectin and Oxidative Stress after Modifiable Lifestyle Interventions in Breast Cancer Cases

Kernel Density Estimation as a Measure of Environmental Exposure Related to Insulin Resistance in Breast Cancer Survivors

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