Physical activity and breast cancer risk by pathological subtype

Lope, Virginia; Martı́n, Miguel; Castelló, Adela; Casla, Soraya; Ruı́z, Amparo; Baena-Cañada, José Manuel; Casas, Ana; Calvo, Lourdes; Bermejo, Begoña; Muñoz, Montserrat; Ramos, Manuel; Juan-Ferré, Ana de; Jara, Carlos; Antón, Antonio; Jimeno, MA; Lluch, Aña; Antolín, Silvia; Estévez, Purificación; Arriola-Arellano, Esperanza; Gavilá, Joaquín; Pérez‐Gómez, Beatriz; Carrasco, Eva; Pollán, Marina

doi:10.1016/j.ygyno.2016.12.014

Cited by 41 publications

(48 citation statements)

References 29 publications

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“…The association between physical activity and breast cancer subtypes have been investigated in several studies (26)(27)(28)(29)(30)(31)(32)(35)(36)(37). Some of these studies had information on ER only, ER and PR (27,(30)(31)(32)37), and others had information on ER, PR, and HER2 (26,28,29,35,36). Of all these studies, two of them had fewer than 700 cases (29,35) and six studies included from 1,921 to 5,882 cases (26-28, 31, 32, 36).…”

Section: Physical Activitymentioning

confidence: 99%

“…Some of these studies had information on ER only, ER and PR (27,(30)(31)(32)37), and others had information on ER, PR, and HER2 (26,28,29,35,36). Of all these studies, two of them had fewer than 700 cases (29,35) and six studies included from 1,921 to 5,882 cases (26-28, 31, 32, 36). The majority of these studies found that physical activity was associated with a decreased risk of ER þ , ER þ PR þ and luminal A-like subtype, and found no association with ER À , ER À PR À and triple-negative breast cancers.…”

Section: Physical Activitymentioning

confidence: 99%

“…Alcohol consumption, physical activity, and smoking are modifiable risk factors that have been associated with breast cancer overall to some or larger degree (4)(5)(6). Several studies have investigated the association between alcohol (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), smoking (14,(19)(20)(21)(22)(23)(24)(25), physical activity (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36), and subtypes of breast cancer. A large meta-analysis suggested stronger positive associations between alcohol and estrogen receptor (ER)-positive tumors and weaker positive associations between alcohol and ER-negative tumors (18).…”

Section: Introductionmentioning

confidence: 99%

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Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case–Control Study from the Norwegian Breast Cancer Screening Program

Ellingjord-Dale

Vos

Hjerkind

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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To what extent alcohol, smoking, and physical activity are associated with the various subtypes of breast cancer is not clear. We took advantage of a large population-based screening cohort to determine whether these risk factors also increase the risk of the poor prognosis subtypes. We conducted a matched case-control study nested within the Norwegian Breast Cancer Screening Program during 2006-2014. A total of 4,402 breast cancer cases with risk factor and receptor data were identified. Five controls were matched to each case on year of birth and year of screening. Conditional logistic regression was used to estimate ORs of breast cancer subtypes adjusted for potential confounders. There were 2,761 luminal A-like, 709 luminal B-like HER2-negative, 367 luminal B-like HER2-positive, 204 HER2-positive, and 361 triple-negative cancers. Current alcohol consumption was associated with breast cancer risk overall [OR 1.26; 95% confidence interval (CI), 1.09-1.45] comparing 6+ glasses a week to never drinkers. However, this risk increase was found only for luminal A-like breast cancer. Smoking 20+ cigarettes a day was associated with an OR of 1.41 (95% CI, 1.06-1.89) overall, with significant trends for luminal A-like and luminal B-like HER2-negative cancer. Current physical activity (4+ hours/week compared with none) was associated with 15% decreased risk of luminal A-like cancer, but not clearly with other subtypes. In this large study, alcohol, smoking, and physical activity were predominantly associated with luminal A-like breast cancer. Alcohol, smoking, and physical activity were associated with luminal A-like breast cancer subtype. .

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Section: Physical Activitymentioning

confidence: 99%

Section: Physical Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case–Control Study from the Norwegian Breast Cancer Screening Program

Ellingjord-Dale

Vos

Hjerkind

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Both retrospective and prospective studies confirmed a doseresponse relationship between increasing levels of physical activity and breast cancer risk, and the association was true for all pathological subtypes of cancer [11,24]. In the Nurses' Health Study II, adolescent physical activity from ages 14-17 years was inversely associated with premenopausal breast cancer risk, with a risk reduction of 19% (95% CI 0.69-0.95) [25].…”

Section: Physical Activity and Breast Cancer Riskmentioning

confidence: 84%

Modifiable Lifestyle Factors: Opportunities for (Hereditary) Breast Cancer Prevention - a Narrative Review

Lammert

Grill

Kiechle³

2018

Breast Care

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Increasing rates of obesity, lack of physical activity, sedentary behavior, and frequent alcohol consumption are major lifestyle-related risk factors for breast cancer. In fact, it has been estimated that about one-third of breast cancer cases are attributable to factors women can change. Most research has focused on examining the impact of one single exposure on breast cancer risk while adjusting for other risk modifiers. Capitalizing on big data, major efforts have been made to evaluate the combined impact of well-established lifestyle factors on overall breast cancer risk. At the individual level, data indicate that even simple behavior modifications could have a considerable impact on breast cancer prevention. Moreover, there is emerging new evidence that adopting a healthy lifestyle may be particularly relevant for women with hereditary susceptibility to breast cancer. On the absolute risk scale, studies suggest that the presence of certain risk factors, such as excessive body weight, had a substantially higher impact on breast cancer risk if women had a hereditary predisposition to cancer. The existing body of knowledge gives the medical professionals guidance as to which factors to focus on when counseling patients. However, well-designed randomized controlled trials utilizing objective methods are crucial to providing concrete recommendations.

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“…Further, we showed that non-physically active women found to be at more risk for FBC (OR=1.78); women who were adherent to international physical activity recommendations had a significant lower risk for FBC for all pathological types [63]. Reduced levels of physical activity are linked with increased risks for FBC [25].…”

Section: /12mentioning

confidence: 99%

Female Breast Cancer: Socio-Demographic, Lifestyle, and Clinical Risk Factors - A Hospital-Based Study in Two Egyptian Governorates

El-Moselhy¹,

Elshemy²,

Sultan³

et al. 2017

BJSTR

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Physical activity and breast cancer risk by pathological subtype

Cited by 41 publications

References 29 publications

Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case–Control Study from the Norwegian Breast Cancer Screening Program

Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case–Control Study from the Norwegian Breast Cancer Screening Program

Modifiable Lifestyle Factors: Opportunities for (Hereditary) Breast Cancer Prevention - a Narrative Review

Female Breast Cancer: Socio-Demographic, Lifestyle, and Clinical Risk Factors - A Hospital-Based Study in Two Egyptian Governorates

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