Physical Activity and Clinical and Functional Status in COPD

Garcia‐Aymerich, Judith; Serra, Ignasi; Gómez, Federico P.; Farrero, Eva; Balcells, Eva; Rodríguez, Diego A.; Batlle, Jordi de; Gimeno, Elena; Donaire-González, David; Orozco-Levi, Mauricio; Sauleda, Jaume; Gea, Joaquim; Rodríguez-Roisín, Robert; Roca, Josep; Agustí, Àlvar; Antó, Josep M.

doi:10.1378/chest.08-2532

Cited by 144 publications

(111 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We observed that CRP positively correlated with MMRC dyspnoea scale (r=0.638, p<0.001) which is consistent with the study conducted by Rachel Garrod et al [27] ,who concluded that inflammation increased with MMRC grade and was significantly correlated with CRP(p=0.002). A study by Judith Garcia-Aymerich et al [28] on COPD patients who presented with acute exacerbation, concluded that physical activity was associated with reduced levels of CRP. Thus, more physically active COPD patients show better functional status.…”

Section: Discussionmentioning

confidence: 99%

Study of Prognostic Association of C-Reactive Protein (A Biomarker) with Clinically Important Predictors of Outcome in Stable and Unstable COPD Patients

2016

AIMDR

View full text Add to dashboard Cite

Background: COPD is characterized by persistent airflow limitation that is progressive and is associated with enhanced chronic inflammatory response in the airways to noxious particles or gases. It has both systemic and pulmonary effects. Since COPD deaths estimated to increase by 30% in next 10 years, cost of treatment will be a heavy burden on global economy. The costs are proportional to pulmonary and extra pulmonary components of the disease. Methods: In this study, we examined 100 patients of COPD, out of which 80 were stable and 20 were unstable. Results: CRP levels were found to be increased in cases more than in controls (13.55+10.83 vs. 2.07+0.82 mg/lit, p<0.001), the levels being higher in unstable patients than in stable patients (33.78+7.74 vs. 8.50+1.81 mg/lit, p<0.001). We also submitted the patients to MMRC dyspnoea scale and found that CRP is positively correlated with MMRC dyspnoea scale (r=0.638, p<0.001) and was inversely correlated with 6-minute walk distance (r= -0.364, p<0.001). There was a significant positive correlation of CRP with BODE index (r=0.780, p<0.001). Conclusion: The study is valuable in detecting the severity of COPD cases both in stable and unstable conditions and to forecast the future morbidity and mortality outcome of such cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Study of Prognostic Association of C-Reactive Protein (A Biomarker) with Clinically Important Predictors of Outcome in Stable and Unstable COPD Patients

2016

AIMDR

View full text Add to dashboard Cite

show abstract

“…Reduced physical activity is associated with greater disease severity (worse lung function) [65,66], higher levels of dyspnoea [65,66], lower exercise capacity [67][68][69][70] and lower health-related quality of life [66,[71][72][73], but these conclusions are based on low-to very low-quality research from mostly cross-sectional studies [56]. How being physically active affects balance and bone mineral density is inconsistent in the literature [56].…”

Section: Copd Patientsmentioning

confidence: 99%

The importance of physical activity

Langer¹,

Demeyer²,

Troosters³

et al. 2015

Controversies in COPD

View full text Add to dashboard Cite

“…Previous studies have shown conflicting results regarding the relationship between dyspnoea and PA 50 65 130 133 . Katajisto et al 65 reported a strong correlation between dyspnoea and PA, while GarciaAymerich et al 50 reported a lack of association between dyspnoea and PA even in patients with severe COPD 133 . Depew et al 130 reported MRC dyspnoea ≥ 3 to be the best independent predictor of severe physical inactivity but the study did not evaluate fatigue.…”

Section: Factors Associated With Low Physical Activitymentioning

confidence: 99%

The relationship between physical function and experience of fatigue in patients with chronic obstructive pulmonary disease

Tödt¹

2014

View full text Add to dashboard Cite

Background Chronic Obstructive Pulmonary Disease (COPD) is increasing throughout the world and most rapidly among women. COPD is characterized by a progressive loss of physical functions. The reason for this is multi-factorial and include not only lung related deficiencies but also several systemic consequences and symptoms of which several are potential restrictors of physical function. The relationship between physical function and symptoms are not clear, especially not among women with COPD. Aim The overall aim of this thesis was to illuminate the relationship between two dimensions of physical function (physical activity and physical capacity) and experience of fatigue. The specific aims were to explore factors associated with low physical activity and to examine experience of fatigue and its relationship to physical capacity and disease severity in men and women with COPD. Methods A cross-sectional study was conducted including 121 patients (67 women) with stable COPD and mean age of 67 (+/-7) years. Physical activity was measured with the International Physical Activity Questionnaire short form. Physical capacity included assessment of lung function (dynamic spirometry), exercise capacity (the 6-minute walk distance [perceived dyspnoea and leg fatigue in connection to the test]) and muscle strength (the Timed Stands Test and grip strength). Fatigue was assessed with structured questions covering the frequency, duration and severity of fatigue the previous month and patients were categorized as those with no fatigue, moderate fatigue or severe fatigue. Data about other symptoms (dyspnoea, anxiety and depression), symptom burden (Memorial Symptom Assessment Scale), fat and fat free mass (bio-impedance analysis) and smoking history was collected. Results Forty-two percent of the patients reported a low physical activity level. A majority of the patients reported experience of fatigue the previous month, 52% moderate fatigue and 25% severe fatigue. Low physical activity was associated with severe fatigue, worse exercise capacity and a higher amount of smoking. There were no differences in experience of fatigue between men and women. Men with fatigue had worse physical capacity and disease severity compared to men without fatigue. Women with fatigue had comparable physical capacity and disease severity to women without fatigue except for a higher perceived leg fatigue after the exercise capacity test. Multiple logistic regression analysis showed that exercise capacity and disease severity were associated with fatigue in both men and women but in women, leg fatigue was also strongly associated with the presence of fatigue. Conclusions Severe fatigue, worse exercise capacity and a higher amount of smoking were independently associated with low PA. This result suggests that patients with severe fatigue might need specific strategies to become more physically active. Presence of fatigue was associated with exercise capacity and disease severity in both men and women. In addition, in women leg fatigue was strongly a...

show abstract

Physical Activity and Clinical and Functional Status in COPD

Cited by 144 publications

References 52 publications

Study of Prognostic Association of C-Reactive Protein (A Biomarker) with Clinically Important Predictors of Outcome in Stable and Unstable COPD Patients

Study of Prognostic Association of C-Reactive Protein (A Biomarker) with Clinically Important Predictors of Outcome in Stable and Unstable COPD Patients

The importance of physical activity

The relationship between physical function and experience of fatigue in patients with chronic obstructive pulmonary disease

Contact Info

Product

Resources

About