Physical activity and depression symptoms in women with chronic illness and the mediating role of health-related quality of life

McIntyre, Erica; Lauche, Romy; Frawley, Jane; Sibbritt, David; Reddy, Prasuna; Adams, Jon

doi:10.1016/j.jad.2019.04.057

Cited by 23 publications

(12 citation statements)

References 39 publications

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“…Exercise has a beneficial recuperative outcome on physical and mental health alike. A cross‐sectional study on women (≥45 years old) with chronic illnesses including diabetes and depression detected less severe depression symptoms in those who participated in robust physical exercise (McIntyre et al., 2019). Another meta‐analysis observed the same beneficial effects in patients with comorbid diabetes and depression (Narita et al., 2019).…”

Section: Possible Intervention Management and Treatment Strategiesmentioning

confidence: 99%

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Subba

Sandhir

Singh

et al. 2021

Eur J of Neuroscience

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Diabetes increases the likelihood of developing depression and vice versa. Research on this bidirectional association has somewhat managed to delineate the interplay among implicated physiological processes. Still, further exploration is required in this context. This review addresses the comorbidity by investigating suspected common pathophysiological mechanisms. One such factor is psychological stress which disturbs the hypothalamic–pituitary–adrenal axis causing hormonal imbalance. This includes elevated cortisol levels, a common biomarker of both depression and diabetes. Disrupted insulin signaling drives the hampered neurotransmission of serotonin, dopamine, and norepinephrine. Also, adipokine hormones such as adiponectin, leptin, and resistin and the orexigenic hormone, ghrelin, are involved in both depression and T2DM. This disarray further interferes with physiological processes encompassing sleep, the gut–brain axis, metabolism, and mood stability. Behavioral coping mechanisms, such as unhealthy eating, mediate disturbed glucose homeostasis, and neuroinflammation. This is intricately linked to oxidative stress, redox imbalance, and mitochondrial dysfunction. However, interventions such as psychotherapy, physical exercise, fecal microbiota transplantation, and insulin‐sensitizing agents can help to manage the distressing condition. The possibility of glucagon‐like peptide 1 possessing a therapeutic role has also been discussed. Nonetheless, there stands an urgent need for unraveling new correlating targets and biological markers for efficient treatment.

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Section: Possible Intervention Management and Treatment Strategiesmentioning

confidence: 99%

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Subba

Sandhir

Singh

et al. 2021

Eur J of Neuroscience

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“…Kim, et al research [9] showed that QOL had a strong correlation with pain and depression or anxiety. McIntyre et al research [10] showed that QOL had a mediating effect between symptoms and depression, which indicated that QOL can indirectly affect depression as a mediating variable. JungHye et al research [11] proposed a QOL protection model, and the model considered QOL as a protective factor that can regulate the negative impact of risk factors on development outcomes.…”

Section: Article Info Abstractmentioning

confidence: 97%

"The Relationship between Quality of Life, Bone Pain, Skin Pruritus and Depression among Patients with Secondary Hyperparathyroidism: A Cross-Sectional Study"

Zhang

2022

BJSTR

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To explore the Relationship between Quality of Life, Bone Pain, Skin Pruritus and Depression among Patients with Secondary Hyperparathyroidism. Methods:A cross-sectional survey was conducted from January 2017 to December 2020 in a third-class hospital in China. The brief table of the QOL measurement scale (QOL-BREF), a self-designed bone pain and skin pruritus scale and the Self-rating Depression Scale (SDS) were used to estimate QOL, bone pain and skin pruritus, and depression, respectively. Pearson's correlation, multiple linear regression analysis and structural equation modeling (SEM) were used for analysis. Results:In SEM, QOL negatively correlated with bone pain (r=-0.509), skin pruritus (r=-0.517) and SDS (r=-0.465). Bone pain significantly (P<0.01) and positively correlated with skin pruritus (r=0.568) and SDS (r=0.450). Skin pruritus significantly (P<0.01) and positively correlated with SDS (r=0.426). In addition, QOL partially mediated the association between bone pain or skin pruritus and depression (mediation proportion of 48.62% or 45.08%).Conclusions: SHPT patients have high depression levels and poor QOL due to bone pain and skin pruritus. Bone pain or skin pruritus could increase depression via the intermediary role of QOL.

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“…Likewise, higher physical disability and higher depression are more likely to seen among older adults that re-admission to the health care centers and mortality rates are results (Hummel et al, 2017). Similarly, low physical activity and high depression are mentioned to be associated (McIntyre et al, 2019). Also, medical diseases are revealed to limit social life that affects higher depressive feelings (Petkus et al, 2017).…”

Section: Original Researchmentioning

confidence: 98%

The association between medical diseases and late-life depression: The presence, number, and type of medical diseases

Şenol-Durak

Durak

2019

Journal of Aging and Long-Term Care

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Medical diseases are highly prevalent among older adults and lead to several changes in psychosocial life. One effect of those problems is seen on depression. On the other hand, whether the type or the number of medical diseases are associated with late-life depression have not examined in the literature. The aim of the present study is to examine whether the place of residence, type of illnesses or a number of illnesses would make a difference on late-life depression. For this purpose, older adults living at home (N= 1100) and nursing home (N=1177) participated in the present study. The Demographic Information Form, including the type and number of medical diseases, and the Geriatric Depression Inventory were applied. Results demonstrated that older adults having two or more medical diseases had higher scores of late-life depression than those with one medical disease and those without suffering any medical disease. Older adults with suffering only psychiatric disease or digestive system disease had a higher level of late-life depression. Besides, older adults having chronic medical diseases had higher scores of late-life depression such as patients with psychiatric disorders, digestive system diseases, cardiovascular system diseases, metabolic and endocrine disorders, rheumatic and musculoskeletal diseases, central nervous system -neurological disorders, urinary system diseases, and sensory system disease. Results were discussed in the light of literature about medical diseases, late-life depression, and caring needs of older adults.

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Physical activity and depression symptoms in women with chronic illness and the mediating role of health-related quality of life

Cited by 23 publications

References 39 publications

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

"The Relationship between Quality of Life, Bone Pain, Skin Pruritus and Depression among Patients with Secondary Hyperparathyroidism: A Cross-Sectional Study"

The association between medical diseases and late-life depression: The presence, number, and type of medical diseases

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