Physical activity and exercise for cancer-related cognitive impairment among individuals affected by childhood cancer: a systematic review and meta-analysis

Bernal, Joshua D K; Recchia, Francesco; Yu, Danny J.; Fong, Daniel Yee Tak; Wong, Stephen Heung-Sang; Chung, Pak‐Kwong; Chan, Derwin King Chung; Capio, Catherine Mamaid; Yu, C.W.; Wong, Sam W.S.; Sit, Cindy H. P.; Chen, Yajun; Thompson, W. R.; Siu, Parco M.

doi:10.1016/s2352-4642(22)00286-3

Cited by 12 publications

(2 citation statements)

References 58 publications

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“…Developing, testing, and implementing cognitive rehabilitation interventions in clinical practice must be prioritized given the paucity of effective cognitive interventions for CCS ( 32 , 33 ). While the current body of evidence for cognitive interventions among CCS is small, clinicians and researchers can consider the use of physical activity and computerized cognitive training programs for CCS ( 34 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

Children with non-central nervous system tumors treated with platinum-based chemotherapy are at risk for hearing loss and cognitive impairments

L’Hotta,

Spence,

Varughese

et al. 2024

Front. Pediatr.

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BackgroundChildhood cancer survivors (CCS) with chemotherapy induced sensorineural hearing loss (SNHL) are at risk for neurocognitive impairments. The purpose of this study was to determine the relationship between SNHL and cognitive function among CCS.ProcedureInclusion: non-CNS solid tumor diagnosis; history of platinum chemotherapy (cisplatin and/or carboplatin); 8–17 years of age; off anti-cancer treatment for ≥6 months; and English speaking. Exclusion: history of intrathecal chemotherapy, cranial radiation, or baseline neurocognitive disorder. Participants completed the NIH Toolbox Cognition Battery at enrollment. T-tests were used to compare participants with normal hearing to those with hearing loss and the total sample with established Toolbox normative data (mean: 50; SD: 10).ResultsFifty-seven individuals enrolled; 52 completed full cognitive testing. Participants were on average 12.2 years of age and 7.0 years since treatment completion. Twenty-one participants (40%) received cisplatin, 27 (52%) carboplatin, and 4 (8%) received both. Fifteen participants (29%) demonstrated SNHL based on the better ear. CCS, regardless of the presence or absence of SNHL, demonstrated significantly lower mean cognitive skills compared to the normative sample in attention, executive function, language- vocabulary and oral reading, processing speed, and fluid, crystallized and total composite scores (all p < 0.01). Participants with SNHL had significantly lower crystallized composite (vocabulary, oral reading) than those with normal hearing (41.9 vs. 47.2, p < 0.05, Cohen's d = 0.62).ConclusionsCCS at risk for platinum induced hearing loss but without cranial radiation or intrathecal chemotherapy exposure demonstrate impaired cognitive skills and those with SNHL demonstrate lower crystallized composite scores.

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Section: Discussionmentioning

confidence: 99%

Children with non-central nervous system tumors treated with platinum-based chemotherapy are at risk for hearing loss and cognitive impairments

L’Hotta,

Spence,

Varughese

et al. 2024

Front. Pediatr.

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“…1 Despite improving prognoses, most children affected by cancer experience, or are at elevated risk, for numerous negative effects during and after treatment, with some effects observed decades later (i.e., late effects) ( 2 ). Health behaviors, including physical activity (any movement requiring energy expenditure) and exercise (structured or planned physical activity), may help this cohort manage the effects of their disease during and beyond treatment ( 3 ). In fact, based on a burgeoning evidence base, guidelines have recently been published suggesting that all children affected by cancer “move more” ( 4 , 5 ).…”

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confidence: 99%

Editorial: Exercise and childhood cancer

2022

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Editorial on the Research Topic Exercise and childhood cancerGlobally, >175,000 children (i.e., individuals aged ≤18-21years) are diagnosed with cancer each year (1). For some of the most common cancers (e.g., acute lymphoblastic leukemia, non-Hodgkin lymphoma), medical advances have led to improved survival rates, with up to 85% expected to survive the disease for at least 5-years (1). 1 Despite improving prognoses, most children affected by cancer experience, or are at elevated risk, for numerous negative effects during and after treatment, with some effects observed decades later (i.e., late effects) (2). Health behaviors, including physical activity (any movement requiring energy expenditure) and exercise (structured or planned physical activity), may help this cohort manage the effects of their disease during and beyond treatment (3). In fact, based on a burgeoning evidence base, guidelines have recently been published suggesting that all children affected by cancer "move more" (4, 5).This Research Topic, Exercise and Childhood Cancer, includes 11 articles that collectively advance the field of "pediatric exercise oncology" ( 6), an area of study exploring physical activity, including exercise, for children affected by cancer. The articles included summarize the current literature, provide further evidence supporting the role of physical activity and exercise for children affected by cancer, and offer insights into forthcoming trials and novel approaches in the field.1 Prognosis varies across cancer types and is lower in middle-and low-income countries.

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Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain

Dai,

Dong,

Shi

et al. 2024

Psychopharmacology

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Physical activity and exercise for cancer-related cognitive impairment among individuals affected by childhood cancer: a systematic review and meta-analysis

Cited by 12 publications

References 58 publications

Children with non-central nervous system tumors treated with platinum-based chemotherapy are at risk for hearing loss and cognitive impairments

Children with non-central nervous system tumors treated with platinum-based chemotherapy are at risk for hearing loss and cognitive impairments

Editorial: Exercise and childhood cancer

Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain

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