The study examines the association between sense of place (SOP) attitudes (e.g., place attachment, place identity, and place dependence) and health-related quality of life (HQOL) in a sample of 261 African residents in New South Wales (Australia). Participants completed measures of the Sense of Place Scale, the World Health Organization Quality of Life-BREF questionnaire, and demographic variables. Study findings are as follows: (a) levels of SOP and place attachment are positively associated with all outcomes of HQOL; (b) place identity is also positively related to HQOL in terms of better environmental health, psychological health, and physical health, but not statistically significant for social relationship and general QOL; (c) place dependence is statistically associated with outcomes of HQOL, except for general QOL which remained insignificant in both the unadjusted and adjusted models. Further ad hoc analyses suggest that African residents from Eastern Africa are more likely to develop the "aussie" place identity than those from Central Africa; and (e) African migrants who have been residents of Australia for more than 5 years, and those who are less educated are more likely to have a stronger SOP and to develop place attachment and behavioral place commitments compared with newly arrived and educated migrants, respectively. Study limitations and implications are carefully discussed.