Physical Activity and Risk of Lymphoma: A Meta-Analysis

Wolter, Pascal; Verhoef, Gregor; Kollen, Boudewijn J.; Kwakkel, Gert; Schepers, Leen; Gosselink, Rik

doi:10.1158/1055-9965.epi-13-0182

Cited by 18 publications

(34 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to the previous meta-analysis (17), the present meta-analysis considered all main hematologic cancer subtypes (non-Hodgkin lymphoma, Hodgkin lymphoma, multiple myeloma, and leukemia). In addition, it incorporated one additional study by Paffenbarger and colleagues (36) that provided risk estimates for physical activity and both non-Hodgkin lymphoma and Hodgkin lymphoma, in addition to leukemia.…”

Section: Discussionmentioning

confidence: 99%

“…A quality score developed by Monninkhof and colleagues (43) and previously used in several meta-analyses of physical activity and specific cancers (17,(43)(44)(45)(46) was applied to assess the methodological quality of the selected studies (supplementary Materials and Methods).…”

Section: Quality Assessmentmentioning

confidence: 99%

“…Despite the existence of numerous biologic pathways potentially linking increased physical activity to decreased risk of hematologic cancer, the epidemiologic evidence relating physical activity to hematologic cancer has been mixed, and the results of a recent meta-analysis on physical activity and lymphoma were not statistically significant (17). Thus, the relation between physical activity and hematologic cancer remains inconclusive.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Physical Activity in Relation to Risk of Hematologic Cancers: A Systematic Review and Meta-analysis

Jochem

Leitzmann

Keimling

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Despite the existence of numerous biologic pathways potentially linking increased physical activity to decreased risk of hematologic cancers, the associations between physical activity and subtypespecific hematologic cancers have not been comprehensively quantified.Methods: We conducted a systematic review and meta-analysis of physical activity in relation to subtypespecific hematologic cancers. We summarized the data from 23 eligible studies (15 cohort and eight casecontrol studies) and estimated summary relative risks (RR) and 95% confidence intervals (CI) using randomeffects models.Results: When comparing high versus low physical activity levels, the RR for non-Hodgkin lymphoma was 0.91 (95% CI, 0.82-1.00), for Hodgkin lymphoma it was 0.86 (95% CI, 0.58-1.26), for leukemia it was 0.97 (95% CI, 0.84-1.13), and for multiple myeloma it was 0.86 (95% CI, 0.68-1.09). When focusing on subtypes of nonHodgkin lymphoma, the RR for diffuse large B-cell lymphoma was 0.95 (95% CI, 0.80-1.14) and for follicular lymphoma it was 1.01 (95% CI, 0.83-1.22). In an exploratory analysis combining all hematologic cancers, high versus low physical activity levels yielded a statistically significant RR of 0.93 (95% CI, 0.88-0.99).Conclusions: Physical activity showed statistically nonsignificant associations with risks of non-Hodgkin lymphoma, Hodgkin lymphoma, multiple myeloma, and leukemia. These findings may not represent a true lack of associations given the variation in high versus low physical activity definitions, the quality of physical activity assessments, and the variability in hematologic cancer classification schemes in individual studies.Impact: Physical activity is unrelated to risks of subtype-specific hematologic cancers. Cancer Epidemiol Biomarkers Prev; 23(5); 833-46. Ó2014 AACR.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Physical Activity in Relation to Risk of Hematologic Cancers: A Systematic Review and Meta-analysis

Jochem

Leitzmann

Keimling

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…Consistent findings were seen in a recent meta-analysis evaluating the association between physical activity and risk of Hodgkin lymphoma and NHL, in which no significant association was demonstrated. 48 Overall, these findings suggest that physical activity alone has little impact on myeloma incidence.…”

Section: Epidemiological Evidence Linking Obesity To Mgus Incidence Amentioning

confidence: 90%

The skinny on obesity and plasma cell myeloma: a review of the literature

Carson

Bates

Tomasson

2014

Bone Marrow Transplant

View full text Add to dashboard Cite

Despite tremendous advances in treatments for myeloma in the past decade, the disease remains incurable in the majority of patients. Here, we review recent data demonstrating an association between obesity and increased risk of myeloma development. This may be due to the pro-inflammatory cytokine profile caused by obesity. Currently, there are no screening or prevention strategies for myeloma, but we propose that obesity-associated inflammatory pathways, or obesity itself, may be amenable to intervention, thereby preventing the transition from pre-malignancy to myeloma. In addition, we suggest that the morbidity, mortality and the significant costs associated with myeloma treatment could be reduced by addressing modifiable risk factors, and that research efforts should explore this novel hypothesis. INTRODUCTIONOver the past several decades, the prevalence of obesity has increased markedly in the United States. 1 Today, two-thirds of the adult population in the United States is overweight (defined as body mass index (BMI) = 25 kg/m 2 and o 30 kg/m 2 ) or obese (BMI 30 kg/m 2 ). 2 A BMI greater than 25 kg/m 2 is associated with increased all-cause mortality. 3,4 This increased risk exists even in the absence of typically-measured metabolic abnormalities, suggesting that there is no 'benign phenotype' for obesity. 5 A substantial number of these premature obesity-related deaths is due to cancer. 6,7 Although the common solid tumor malignancies have received much attention, data from case-control and prospectively followed cohort studies have also demonstrated a positive association between obesity and plasma cell myeloma incidence and death. 7,8

show abstract

“…There is limited and inconsistent research regarding the association between physical activity and NHL risk; only 13 previous studies have investigated this association. Two recent meta-analyses of these studies indicate that people with the highest physical activity levels may have a slightly lower risk of NHL than people with the lowest physical activity levels (5,6). Although there is no established etiologic pathway that explains how physical activity may reduce NHL risk, several plausible mechanisms have been suggested.…”

Section: Introductionmentioning

confidence: 99%

Lifetime Physical Activity and the Risk of Non-Hodgkin Lymphoma

Boyle

Gallagher

Gascoyne

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Research regarding the association between physical activity and the risk of non-Hodgkin lymphoma (NHL) is limited and inconsistent, and few studies have investigated whether the intensity and timing of physical activity influence the association. A case-control study of NHL was conducted in British Columbia, Canada, in 2000 to 2004. Data were collected on various NHL risk factors, including moderate-intensity and vigorous-intensity physical activity performed over the lifetime. Logistic regression was used to estimate the association between physical activity and the risk of NHL. This analysis included 818 controls and 749 cases. Lifetime vigorousintensity physical activity was inversely associated with NHL risk. Participants in the second, third, and fourth quartiles of lifetime vigorous-intensity physical activity had an approximately 25% to 30% lower risk of NHL than those in the lowest quartile [adjusted odds ratios, 0.69 (95% confidence interval [CI], 0.52-0.93); 0.68 (95% CI, 0.50-0.92); and 0.75 (95% CI, 0.55-1.01), respectively]. No consistent associations were observed for total or moderateintensity physical activity. There were no apparent age periods in which physical activity appeared to confer a greater risk reduction. In this study, we found that lifetime vigorous-intensity physical activity was associated with a significantly reduced risk of NHL. Given this finding, more research on physical activity intensity and timing in relation to NHL risk is warranted. Cancer Epidemiol Biomarkers Prev; 24(5); 873-7. Ó2015 AACR.

show abstract

Physical Activity and Risk of Lymphoma: A Meta-Analysis

Cited by 18 publications

References 57 publications

Physical Activity in Relation to Risk of Hematologic Cancers: A Systematic Review and Meta-analysis

Physical Activity in Relation to Risk of Hematologic Cancers: A Systematic Review and Meta-analysis

The skinny on obesity and plasma cell myeloma: a review of the literature

Lifetime Physical Activity and the Risk of Non-Hodgkin Lymphoma

Contact Info

Product

Resources

About