Physical activity and sedentary levels among people living with epilepsy: A systematic review and meta-analysis

Vancampfort, Davy; Ward, Philip B.; Stubbs, Brendon

doi:10.1016/j.yebeh.2019.05.052

Cited by 12 publications

(9 citation statements)

References 55 publications

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“…Physical activity is an element of lifestyle, which is important for maintaining health. Although participants with epilepsy as well as healthy participants in the study were moderately active, patients with epilepsy spent more time during the day sitting and less often performed intensive and moderate physical activity during the week, what is consistent with other ndings [70]. Lower physical activity may be affected by low occupational activity of epileptics compared to healthy people, 36.7% compared to 82.9%, respectively.…”

Section: Discussionsupporting

confidence: 87%

“…Lower physical activity may be affected by low occupational activity of epileptics compared to healthy people, 36.7% compared to 82.9%, respectively. The latest meta-analysis of population studies shows that further research is needed before speci c recommendations on physical activity in people with epilepsy are formulated [70]. Among patients with epilepsy, but not in the control group, a positive relationship was found between the level of physical activity and serum concentration of vitamin D3.…”

Section: Discussionmentioning

confidence: 99%

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Dietary and Lifestyle Behavior in Adults With Epilepsy Needs Improvement: A Case-control Study From North-eastern Poland

Kulesza

Cyuńczyk

Kochanowicz

et al. 2020

Preprint

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Background: Several factors predispose people with epilepsy to cardiovascular diseases. Among them nutrition and lifestyle have not been sufficiently studied. Methods. The study involved 60 epileptic male and female volunteers and 70 healthy controls, corresponding to age and gender. Medical information was collected during the study and a detailed questionnaire survey concerning eating and lifestyle habits was conducted. Physical activity was evaluated using International Physical Activity Questionnaire (IPAQ). Nutritional status was assessed by bioelectric impedance. Venous blood samples were taken for lipid and 25-hydroxyvitamin D3 (25(OH)D3) analyses. Results. A tendency to an increase in LDL cholesterol was found in epileptics. Significantly higher body fat and insignificantly higher visceral fat was found in epileptic men compared to healthy men. In epileptic women a tendency to lower lean body mass was found. Patients with epilepsy were more sedentary, had lower consumption of cottage cheese, fruit, pulses, nuts and seeds, vitamin C and potassium, and higher intake of sugar-sweetened soda, energy from fat and sodium compared to healthy people. As a positive point, epileptics consumed less coffee and alcoholic beverages. More than 80% of diets of epilepsy people were low in folic acid, vitamin D and calcium, but similar tendency was observed in the healthy people. The diets of patients with epilepsy were in a higher percentage poor in niacin, vitamin C and potassium compared to the control group, 25% to 7%, 50% to 31% and 73 to 56% respectively. A significantly lower serum concentration of 25(OH)D3 was observed in epileptic individuals, which in this group was found to be positively modulated by physical activity.Conclusions. The study indicates that several behavior-related habits, which may predispose epileptic people to cardiovascular disease, need to be improved. For this reason, patients with epilepsy should be provided with more comprehensive medical care, including advice on nutrition and physical activity.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Dietary and Lifestyle Behavior in Adults With Epilepsy Needs Improvement: A Case-control Study From North-eastern Poland

Kulesza

Cyuńczyk

Kochanowicz

et al. 2020

Preprint

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“…Role of Exercise People with epilepsy are less likely to engage or even intend to engage in physical activities [42][43][44]. In a Norwegian sample, the proportion of people never exercising was significantly greater for an epilepsy cohort than the average population [45].…”

Section: 4mentioning

confidence: 98%

Drivers for the comorbidity of type 2 diabetes mellitus and epilepsy: A scoping review

Shlobin

Sander

2020

Epilepsy & Behavior

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Epilepsy, a common neurologic condition, is associated with a greater prevalence of type 2 diabetes mellitus (T2DM). We examined potential drivers for the comorbidity of epilepsy and T2DM in an attempt to elucidate possible biological mechanisms underlying the development of processes in individuals. We searched PubMed and Medline up to December 2019. Our search yielded 3,361 articles, of which 82 were included in the scoping review. We reviewed articles with a focus on the association of epilepsy and T2DM, drivers, and biological mechanisms. Epilepsy is associated with obesity and obesity is associated with T2DM. Treatment with valproate (either sodium or acid) is associated with weight increase and hyperinsulinemia, while topiramate causes weight loss. People with epilepsy are less likely to exercise which is protective against obesity. Mitochondrial dysfunction and adiponectin deficiency are common to epilepsy and T2DM. One possible mechanism for the comorbidity is mitochondrial dysfunction and adiponectin deficiency which promotes epilepsy, obesity, and T2DM. Another possible mechanism is that people with epilepsy are more likely to be obese due to lack of exercise and the effects of some antiseizure medications, which makes them susceptible to T2DM due to the development of mitochondrial dysfunction and adiponectin deficiency. A third mechanism is that people with epilepsy have greater mitochondrial dysfunction and lower adiponectin levels than people without epilepsy at baseline, which may exacerbate after treatment with antiseizure medications. Future research involving a combined genetic and molecular pathway approach will likely yield valuable insight regarding the comorbidity of epilepsy and T2DM.

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“…In general, several studies reported that physical activity has a positive influence on seizure frequency and severity Vancampfort, Ward, & Stubbs, 2019). As a result, attitudes regarding sports and epilepsy have changed considerably in recent decades, and presently, the risk of convulsive seizures during sports practice is minimal in cases of well-managed epilepsy (van Gorp et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Physical Activity, Ketogenic Diet, and Epilepsy: A Mini-Review

2021

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One-third of patients with epilepsy do not respond to antiepileptic drugs and may seek complementary and alternative treatment modalities. Dietary therapies, such as the ketogenic diet (KD), the modified Atkins diet, as well as the medium-chain triglyceride and the low glycaemic index diets, have been successfully implemented with some forms of epilepsy and are growing in utilization. The KD is a high-fat, low-protein, low-carbohydrate diet that has been used for various conditions for over a century. Insights into the mechanism of action of these diets may provide more targeted interventions for patients with epilepsy. Knowledge of these mechanisms is growing and includes neuroprotective effects on oxidative stress, neuroinflammation, potassium channels in the brain, and mitochondrial function. In this review, we explain the role of physical exercise and the ketogenic diet on epilepsy.

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Physical activity and sedentary levels among people living with epilepsy: A systematic review and meta-analysis

Cited by 12 publications

References 55 publications

Dietary and Lifestyle Behavior in Adults With Epilepsy Needs Improvement: A Case-control Study From North-eastern Poland

Dietary and Lifestyle Behavior in Adults With Epilepsy Needs Improvement: A Case-control Study From North-eastern Poland

Drivers for the comorbidity of type 2 diabetes mellitus and epilepsy: A scoping review

Physical Activity, Ketogenic Diet, and Epilepsy: A Mini-Review

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